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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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April 2009 Volume 21 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Beta-interferon, retinoids and tamoxifen in metastatic breast cancer: Long-term follow-up of a phase II study

  • Authors:
    • Francesco Recchia
    • Gigliola Sica
    • Giampiero Candeloro
    • Stefano Necozione
    • Roberta Bisegna
    • Massimo Bratta
    • Silvio Rea

  • View Affiliations / Copyright

    Affiliations: Oncologia, Ospedale Civile di Avezzano, 67051 Avezzano, AQ, Italy. frecchia1946@libero.it
  • Pages: 1011-1016
    |
    Published online on: April 1, 2009
       https://doi.org/10.3892/or_00000317
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Abstract

Based on a series of in vitro data, including the additive and/or synergistic antiproliferative effect of interferon and tamoxifen on breast cancer cell lines, and on clinical reports, we designed a pilot phase II study to test the activity and toxicity of simultaneous administration of β-interferon (β-IFN), retinoids (R) and tamoxifen (TAM) as a salvage therapy in a group of patients with metastatic breast cancer (MBC). Herein we describe the outcome of this cohort of patients after a median follow-up of 150 months. Sixty-five stage IV breast cancer patients, 13 pre-treated with hormones, 38 with chemotherapy and 15 with both, received, as a salvage therapy, TAM, β-IFN and R. Among 65 evaluable patients, 36 achieved a clinical response (55.5%) (95% c.i. 42-67.7%). Toxicity was moderate and mainly hepatic. Median progression-free and overall survival, which did not show any statistically significant difference in patients with different estrogen and progesterone receptor content, were 43 months and 47.9 months, respectively. In conclusion, the study shows that long-term treatment with TAM, β-IFN and R in MBC is feasible, has moderate toxicity and seems to give a long-term benefit, irrespective of the receptorial status.

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Copy and paste a formatted citation
Spandidos Publications style
Recchia F, Sica G, Candeloro G, Necozione S, Bisegna R, Bratta M and Rea S: Beta-interferon, retinoids and tamoxifen in metastatic breast cancer: Long-term follow-up of a phase II study. Oncol Rep 21: 1011-1016, 2009.
APA
Recchia, F., Sica, G., Candeloro, G., Necozione, S., Bisegna, R., Bratta, M., & Rea, S. (2009). Beta-interferon, retinoids and tamoxifen in metastatic breast cancer: Long-term follow-up of a phase II study. Oncology Reports, 21, 1011-1016. https://doi.org/10.3892/or_00000317
MLA
Recchia, F., Sica, G., Candeloro, G., Necozione, S., Bisegna, R., Bratta, M., Rea, S."Beta-interferon, retinoids and tamoxifen in metastatic breast cancer: Long-term follow-up of a phase II study". Oncology Reports 21.4 (2009): 1011-1016.
Chicago
Recchia, F., Sica, G., Candeloro, G., Necozione, S., Bisegna, R., Bratta, M., Rea, S."Beta-interferon, retinoids and tamoxifen in metastatic breast cancer: Long-term follow-up of a phase II study". Oncology Reports 21, no. 4 (2009): 1011-1016. https://doi.org/10.3892/or_00000317
Copy and paste a formatted citation
x
Spandidos Publications style
Recchia F, Sica G, Candeloro G, Necozione S, Bisegna R, Bratta M and Rea S: Beta-interferon, retinoids and tamoxifen in metastatic breast cancer: Long-term follow-up of a phase II study. Oncol Rep 21: 1011-1016, 2009.
APA
Recchia, F., Sica, G., Candeloro, G., Necozione, S., Bisegna, R., Bratta, M., & Rea, S. (2009). Beta-interferon, retinoids and tamoxifen in metastatic breast cancer: Long-term follow-up of a phase II study. Oncology Reports, 21, 1011-1016. https://doi.org/10.3892/or_00000317
MLA
Recchia, F., Sica, G., Candeloro, G., Necozione, S., Bisegna, R., Bratta, M., Rea, S."Beta-interferon, retinoids and tamoxifen in metastatic breast cancer: Long-term follow-up of a phase II study". Oncology Reports 21.4 (2009): 1011-1016.
Chicago
Recchia, F., Sica, G., Candeloro, G., Necozione, S., Bisegna, R., Bratta, M., Rea, S."Beta-interferon, retinoids and tamoxifen in metastatic breast cancer: Long-term follow-up of a phase II study". Oncology Reports 21, no. 4 (2009): 1011-1016. https://doi.org/10.3892/or_00000317
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