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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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June 2009 Volume 21 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Elevated expression of CTRP3/cartducin contributes to promotion of osteosarcoma cell proliferation

  • Authors:
    • Hironori Akiyama
    • Souhei Furukawa
    • Satoshi Wakisaka
    • Takashi Maeda

  • View Affiliations / Copyright

    Affiliations: Department of Anatomy and Cell Biology, Graduate School of Dentistry, Osaka University, Osaka 565-0871, Japan
  • Pages: 1477-1481
    |
    Published online on: June 1, 2009
       https://doi.org/10.3892/or_00000377
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Abstract

CTRP3/cartducin, a novel secretory protein, is a member of the C1q and tumor necrosis factor (TNF)-related protein (CTRP) superfamily, and plays important roles in regulating both embryonic cartilage development and postnatal longitudinal bone growth. CTRP3/cartducin is expressed in human osteosarcomas. We hypothesized that CTRP3/cartducin might have a role in osteosarcoma tumor growth and metastasis. Murine osteosarcoma cell lines, NHOS and LM8, were used as a model. RT-PCR analysis showed that the mRNA level of CTRP3/cartducin was increased in these two murine osteosarcoma cell lines compared with its level in normal murine osteoblast MC3T3-E1 cells. Western blot analysis showed that the protein level of CTRP3/cartducin was also increased in these two osteosarcoma cell lines. Stimulation of NHOS and LM8 cells by CTRP3/cartducin promoted tumor cell growth but not migration in vitro. Further, CTRP3/cartducin stimulation led to the activation of extracellular signal-regulated kinase 1/2 (ERK1/2) in these two osteosarcoma cell lines. MAPK/ERK kinase 1/2 (MEK1/2) inhibitor, U0126, blocked CTRP3/cartducin-induced cell proliferation. These results suggest that CTRP3/cartducin expression may play a role in osteosarcoma tumor growth associated with activation of the ERK1/2 signaling pathway.

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Copy and paste a formatted citation
Spandidos Publications style
Akiyama H, Furukawa S, Wakisaka S and Maeda T: Elevated expression of CTRP3/cartducin contributes to promotion of osteosarcoma cell proliferation. Oncol Rep 21: 1477-1481, 2009.
APA
Akiyama, H., Furukawa, S., Wakisaka, S., & Maeda, T. (2009). Elevated expression of CTRP3/cartducin contributes to promotion of osteosarcoma cell proliferation. Oncology Reports, 21, 1477-1481. https://doi.org/10.3892/or_00000377
MLA
Akiyama, H., Furukawa, S., Wakisaka, S., Maeda, T."Elevated expression of CTRP3/cartducin contributes to promotion of osteosarcoma cell proliferation". Oncology Reports 21.6 (2009): 1477-1481.
Chicago
Akiyama, H., Furukawa, S., Wakisaka, S., Maeda, T."Elevated expression of CTRP3/cartducin contributes to promotion of osteosarcoma cell proliferation". Oncology Reports 21, no. 6 (2009): 1477-1481. https://doi.org/10.3892/or_00000377
Copy and paste a formatted citation
x
Spandidos Publications style
Akiyama H, Furukawa S, Wakisaka S and Maeda T: Elevated expression of CTRP3/cartducin contributes to promotion of osteosarcoma cell proliferation. Oncol Rep 21: 1477-1481, 2009.
APA
Akiyama, H., Furukawa, S., Wakisaka, S., & Maeda, T. (2009). Elevated expression of CTRP3/cartducin contributes to promotion of osteosarcoma cell proliferation. Oncology Reports, 21, 1477-1481. https://doi.org/10.3892/or_00000377
MLA
Akiyama, H., Furukawa, S., Wakisaka, S., Maeda, T."Elevated expression of CTRP3/cartducin contributes to promotion of osteosarcoma cell proliferation". Oncology Reports 21.6 (2009): 1477-1481.
Chicago
Akiyama, H., Furukawa, S., Wakisaka, S., Maeda, T."Elevated expression of CTRP3/cartducin contributes to promotion of osteosarcoma cell proliferation". Oncology Reports 21, no. 6 (2009): 1477-1481. https://doi.org/10.3892/or_00000377
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