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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July 2009 Volume 22 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2009 Volume 22 Issue 1

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Article

Fluorescence diagnosis of lymph node metastasis of lung cancer in a mouse model

  • Authors:
    • Hiromitsu Takizawa
    • Kazuya Kondo
    • Hiroaki Toba
    • Koichiro Kenzaki
    • Shoji Sakiyama
    • Akira Tangoku

  • View Affiliations / Copyright

    Affiliations: Department of Thoracic, Endocrine Surgery and Oncology, Institute of Health Bioscience, The University of Tokushima Graduate School, Tokushima 770-8503, Japan
  • Pages: 17-21
    |
    Published online on: July 1, 2009
       https://doi.org/10.3892/or_00000400
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Abstract

Fluorescence diagnosis of lymph node metastasis of non-small cell lung cancer has not been reported previously. This study was conducted to evaluate the feasibility of fluorescence detection using 5-aminolevulinic acid and mono-L-aspartyl chlorine e6 for lymph node metastasis in a lung cancer mouse model. Human lung cancer cell line Ma44-3, which forms metastatic lymph nodes in the mediastinum, was injected into the left lungs of 6 severe combined immunodeficiency disease mice. Two weeks after implantation, 2 groups of 3 mice received oral administration of 5-aminolevulinic acid (100 mg/kg) or intraperitoneal administration of mono-L-aspartyl chlorine e6 (5 mg/kg). Both lungs and mediastinal organs were removed en-bloc and illuminated with blue light (405 nm) to evaluate the detectability of lung tumors and metastatic lymph nodes in the mediastinum. These organs were evaluated histopathologically. Clear red fluorescence was observed in the lung tumors of all mice. Metastatic lymph nodes had formed in 5 of 6 mice and were detected by fluorescent detection in all 5 mice even though one of the lymph nodes was invisible macroscopically under white light. In conclusion, fluorescence diagnosis of lymph node metastasis is possible in a mouse model. The successful result with small lymph node metastasis suggests the possibility of clinical application.

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Copy and paste a formatted citation
Spandidos Publications style
Takizawa H, Kondo K, Toba H, Kenzaki K, Sakiyama S and Tangoku A: Fluorescence diagnosis of lymph node metastasis of lung cancer in a mouse model. Oncol Rep 22: 17-21, 2009.
APA
Takizawa, H., Kondo, K., Toba, H., Kenzaki, K., Sakiyama, S., & Tangoku, A. (2009). Fluorescence diagnosis of lymph node metastasis of lung cancer in a mouse model. Oncology Reports, 22, 17-21. https://doi.org/10.3892/or_00000400
MLA
Takizawa, H., Kondo, K., Toba, H., Kenzaki, K., Sakiyama, S., Tangoku, A."Fluorescence diagnosis of lymph node metastasis of lung cancer in a mouse model". Oncology Reports 22.1 (2009): 17-21.
Chicago
Takizawa, H., Kondo, K., Toba, H., Kenzaki, K., Sakiyama, S., Tangoku, A."Fluorescence diagnosis of lymph node metastasis of lung cancer in a mouse model". Oncology Reports 22, no. 1 (2009): 17-21. https://doi.org/10.3892/or_00000400
Copy and paste a formatted citation
x
Spandidos Publications style
Takizawa H, Kondo K, Toba H, Kenzaki K, Sakiyama S and Tangoku A: Fluorescence diagnosis of lymph node metastasis of lung cancer in a mouse model. Oncol Rep 22: 17-21, 2009.
APA
Takizawa, H., Kondo, K., Toba, H., Kenzaki, K., Sakiyama, S., & Tangoku, A. (2009). Fluorescence diagnosis of lymph node metastasis of lung cancer in a mouse model. Oncology Reports, 22, 17-21. https://doi.org/10.3892/or_00000400
MLA
Takizawa, H., Kondo, K., Toba, H., Kenzaki, K., Sakiyama, S., Tangoku, A."Fluorescence diagnosis of lymph node metastasis of lung cancer in a mouse model". Oncology Reports 22.1 (2009): 17-21.
Chicago
Takizawa, H., Kondo, K., Toba, H., Kenzaki, K., Sakiyama, S., Tangoku, A."Fluorescence diagnosis of lymph node metastasis of lung cancer in a mouse model". Oncology Reports 22, no. 1 (2009): 17-21. https://doi.org/10.3892/or_00000400
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