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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
July 2009 Volume 22 Issue 1

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Article

Combination of p53 expression and p21 loss has an independent prognostic impact on sporadic colorectal cancer

Aurelia Noske, Sybille Lipka, Jan Budczies, Kathrin Müller, Christoph Loddenkemper, Heinz Johannes Buhr, Martin Kruschewski
Pages: 3-9
Published online on: 01 July 2009

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Article

Expression of 14-3-3σ in cervical squamous cell carcinomas: Relationship with clinical outcome

Ruth Holm, Tayeba Ali, Debbie H. Svendsrud, Jahn M. Nesland, Gunnar B. Kristensen, Heidi Lyng
Pages: 11-15
Published online on: 01 July 2009

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Article

Fluorescence diagnosis of lymph node metastasis of lung cancer in a mouse model

Hiromitsu Takizawa, Kazuya Kondo, Hiroaki Toba, Koichiro Kenzaki, Shoji Sakiyama, Akira Tangoku
Pages: 17-21
Published online on: 01 July 2009

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Article Open Access

Anti-tumor effect of cimetidine via inhibiting angiogenesis factors in N-butyl-N-(4-hydroxybutyl) nitrosamine-induced mouse and rat bladder carcinogenesis

Yoshitomo Chihara, Kiyohide Fujimoto, Makito Miyake, Yoshio Hiasa, Yoshihiko Hirao
Pages: 23-28
Published online on: 01 July 2009

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Article

It is possible that tumour-infiltrating granulocytes promote tumour progression

Huanran Liu, Hideyuki Ubukata, Takanobu Tabuchi, Akira Takemura, Gyou Motohashi, Motoi Nishimura, Tetsuro Satani, Jianwei Hong, Motonobu Katano, Ichiro Nakada, Abbi R. Saniabadi, Takafumi Tabuchi
Pages: 29-33
Published online on: 01 July 2009

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Article

p12CDK2-AP1 is associated with tumor progression and a poor prognosis in esophageal squamous cell carcinoma

Yukiharu Hiyoshi, Masayuki Watanabe, Koutaro Hirashima, Ryuichi Karashima, Nobutaka Sato, Yu Imamura, Youhei Nagai, Naoya Yoshida, Eiichiro Toyama, Naoko Hayashi, Hideo Baba
Pages: 35-39
Published online on: 01 July 2009

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Article

Enhanced S100A4 protein expression is clinicopathologically significant to metastatic potential and p53 dysfunction in colorectal cancer

Joo Heon Kim, Chang Nam Kim, Soo Young Kim, Jung Sam Lee, Daeho Cho, Jae Wha Kim, Sun Young Yoon
Pages: 41-47
Published online on: 01 July 2009

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Article

AFPep, a novel drug for the prevention and treatment of breast cancer, does not disrupt the estrous cycle or fertility in rats

Amanda M. Tower, Andrea Trinward, Katie Lee, Leroy Joseph, Herbert I. Jacobson, James A. Bennett, Thomas T. Andersen
Pages: 49-56
Published online on: 01 July 2009

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Article

Expression and localization of FOXO1 in non-small cell lung cancer

Takayo Maekawa, Yoshimasa Maniwa, Takefumi Doi, Wataru Nishio, Masahiro Yoshimura, Chiho Ohbayashi, Yoshitake Hayashi, Yutaka Okita
Pages: 57-64
Published online on: 01 July 2009

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Article

Establishment and biological analysis of the EC109/CDDP multidrug-resistant esophageal squamous cell carcinoma cell line

Jing Wen, Bin Zheng, Yi Hu, Xu Zhang, Hong Yang, Kong-Jia Luo, Xing Zhang, Yong-Feng Li, Jian-Hua Fu
Pages: 65-71
Published online on: 01 July 2009

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Article

The overexpression of multidrug resistance-associated proteins and gankyrin contribute to arsenic trioxide resistance in liver and gastric cancer cells

Xi Chen, Mu Zhang, Lian-Xin Liu
Pages: 73-80
Published online on: 01 July 2009

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Article

High incidence of chromosomal abnormalities at 1p36 and 9p21 in early-stage central type squamous cell carcinoma and squamous dysplasia of bronchus detected by autofluorescence bronchoscopy

Kiyoko Shibukawa, Naoyuki Miyokawa, Yoshihiko Tokusashi, Takaaki Sasaki, Shinobu Osanai, Yoshinobu Ohsaki
Pages: 81-87
Published online on: 01 July 2009

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Article

Overexpression of mitogen-activated protein kinase kinase 4 and nuclear factor-κB in laryngeal squamous cell carcinoma: A potential indicator for poor prognosis

Chuang Huang, Kun Huang, Chi Wang, Zhen-Dong Jiang, Xing-Xing Li, Hong-Peng Wang, Hong-Yan Chen
Pages: 89-95
Published online on: 01 July 2009

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Article

Curcumin induces apoptosis through FAS and FADD, in caspase-3-dependent and -independent pathways in the N18 mouse-rat hybrid retina ganglion cells

Hsu-Feng Lu, Kuang-Chi Lai, Shu-Chun Hsu, Hui-Ju Lin, Mei-Due Yang, Yuan-Liang Chen, Ming-Jen Fan, Jai-Sing Yang, Pi-Yun Cheng, Chao-Lin Kuo, Jing-Gung Chung
Pages: 97-104
Published online on: 01 July 2009

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Article Open Access

Antiangiogenic versus cytotoxic therapeutic approaches in a mouse model of pancreatic cancer: An experimental study with a multitarget tyrosine kinase inhibitor (sunitinib), gemcitabine and radiotherapy

Veerle F. Casneuf, Pieter Demetter, Tom Boterberg, Louke Delrue, Marc Peeters, Nancy Van Damme
Pages: 105-113
Published online on: 01 July 2009

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Article

Dual functional molecular imaging probe targeting CD20 with PET and optical imaging

Pramila Paudyal, Bishnuhari Paudyal, Yasuhiko Iida, Noboru Oriuchi, Hirofumi Hanaoka, Hideyuki Tominaga, Tomohiro Ishikita, Hiroki Yoshioka, Tetsuya Higuchi, Keigo Endo
Pages: 115-119
Published online on: 01 July 2009

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Article

Inhibition of cell proliferation, migration and invasion by DNAzyme targeting MMP-9 in A549 cells

Lifang Yang, Weizhong Zeng, Dan Li, Rui Zhou
Pages: 121-126
Published online on: 01 July 2009

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Article

Comprehensive analysis of excision repair complementation group 1, glutathione S-transferase, thymidylate synthase and uridine diphosphate glucuronosyl transferase 1A1 polymorphisms predictive for treatment outcome in patients with advanced gastric cancer treated with FOLFOX or FOLFIRI

Bong-Gun Seo, Hyuk-Chan Kwon, Sung Yong Oh, Suee Lee, Sung-Gun Kim, Sung-Hyun Kim, Hoon Han, Hyo-Jin Kim
Pages: 127-136
Published online on: 01 July 2009

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Article

Impact of chromosome 13 deletion and plasma cell load on long-term survival of patients with multiple myeloma undergoing autologous transplantation

Esbjörn Paul, Tolga Sutlu, Stefan Deneberg, Evren Alici, Bo Björkstrand, Monika Jansson, Richard Lerner, Ann Wallblom, Gösta Gahrton, Hareth Nahi
Pages: 137-142
Published online on: 01 July 2009

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Article

Trichostatin A with adenovirus-mediated p53 gene transfer synergistically induces apoptosis in breast cancer cell line MDA-MB-231

Sei-Ichiro Nakajima, Hiroto Niizeki, Mitsuo Tada, Koji Nakagawa, Satoshi Kondo, Futoshi Okada, Masanobu Kobayashi
Pages: 143-148
Published online on: 01 July 2009

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Article

Detection of glypican-3-specific CTLs in chronic hepatitis and liver cirrhosis

Emiko Hayashi, Yutaka Motomura, Hirofumi Shirakawa, Toshiaki Yoshikawa, Nobuyuki Oba, Shuta Nishinakagawa, Yasuhiro Mizuguchi, Tatsuya Kojima, Kazuhiro Nomura, Tetsuya Nakatsura
Pages: 149-154
Published online on: 01 July 2009

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Article

Susceptibility of the human LNCaP prostate cancer cells to the apoptotic effect of marina crystal minerals (MCM) in vitro

Mamdooh Ghoneum, Sastry Gollapudi
Pages: 155-159
Published online on: 01 July 2009

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Article

β-Elemene, a novel plant-derived antineoplastic agent, increases cisplatin chemosensitivity of lung tumor cells by triggering apoptosis

Qingdi Q. Li, Gangduo Wang, Manchao Zhang, Christopher F. Cuff, Lan Huang, Eddie Reed
Pages: 161-170
Published online on: 01 July 2009

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Article

Does dexamethasone inhibit anticancer activity of cetuximab in squamous cell carcinoma cell lines of the head and neck?

Jens Wagenblast, Mehran Baghi, Susanne Mörtel, Daniel Hirth, Laura Thron, Christoph Arnoldner, Wolfgang Gstöttner, Angelika May, Markus Hambek
Pages: 171-176
Published online on: 01 July 2009

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Article

Expression of Jun and Fos proteins in ovarian tumors of different malignant potential and in ovarian cancer cell lines

Sibyll Hein, Sven Mahner, Christine Kanowski, Thomas Löning, Fritz Jänicke, Karin Milde-Langosch
Pages: 177-183
Published online on: 01 July 2009

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Article

Characterization of cytomegalovirus pp65-HLA-A24 peptide-specific CTL lines from metastatic melanoma patients

Yasuto Akiyama, Sachiko Tai, Masaru Komiyama, Masako Takikawa, Chie Ohshita, Akifumi Yamamoto, Naoya Yamazaki, Yoshio Kiyohara
Pages: 185-191
Published online on: 01 July 2009

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Article

Apogossypolone inhibits cell growth by inducing cell cycle arrest in U937 cells

Jian Sun, Zhi-Ming Li, Zhe-Yu Hu, Zhao-Lei Zeng, Da-Jun Yang, Wen-Qi Jiang
Pages: 193-198
Published online on: 01 July 2009

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Article

Correlation of promoter hypermethylation in hTERT, DAPK and MGMT genes with cervical oncogenesis progression

Dimitrios Iliopoulos, Pagona Oikonomou, Ioannis Messinis, Aspasia Tsezou
Pages: 199-204
Published online on: 01 July 2009

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Article

Serum protein profiling for diagnosis of breast cancer using SELDI-TOF MS

Marie-Christine W. Gast, Carla H. Van Gils, Lodewijk F.A. Wessels, Nathan Harris, Johannes M.G. Bonfrer, Emiel J.TH. Rutgers, Jan H.M. Schellens, Jos H. Beijnen
Pages: 205-213
Published online on: 01 July 2009

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Article

The effect of MG132, a proteasome inhibitor on HeLa cells in relation to cell growth, reactive oxygen species and GSH

Yong Hwan Han, Hwa Jin Moon, Bo Ra You, Woo Hyun Park
Pages: 215-221
Published online on: 01 July 2009

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Journal Cover
March-2026 Volume 55 Issue 3

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

Collaborative breakthroughs in precision diagnosis and treatment of nasopharyngeal cancer: Biomarker‑driven screening and endoscopic minimally invasive surgery reshape the new paradigm of early intervention (Review)

E Jin, Wang Lin, Xiandong Zeng
Article Number: 53
Published online on: 23 January 2026

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Key immune cells in the tumor immune microenvironment of colorectal cancer: Roles and research advances (Review)

Ming Qiu, Chongyuan Lan, Minglin Lin, Hui Ma
Article Number: 52
Published online on: 21 January 2026

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Correction Open Access

[Corrigendum] Icaritin acts synergistically with epirubicin to suppress bladder cancer growth through inhibition of autophagy

Xiu-Wu Pan, Lin Li, Yi Huang, Hai Huang, Dan-Feng Xu, Yi Gao, Lu Chen, Ji-Zhong Ren, Jian-Wei Cao, Yi Hong, Xin-Gang Cui
Article Number: 51
Published online on: 21 January 2026

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Review Open Access

Epigenetic mechanisms and therapeutic advances in diffuse midline glioma (Review)

Wenbo Wu, Wenlin Chen, Wenbin Ma, Yu Wang
Article Number: 50
Published online on: 20 January 2026

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Review Open Access

Recapitulating lung cancer metastasis in vitro: Advances in organoid models and challenges in clinical translation (Review)

Jian Jiang, Guomin Dong, Zhiyun Zhang, Xiaoyuan Lei, Fanshu Huang, Suoni Li, Jiequn Ma, Jie Bai, Qian Ge, Hui Wei, Zheng Zhao
Article Number: 49
Published online on: 20 January 2026

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Article Open Access

GPR176 enhances the epithelial‑mesenchymal transition in gastric cancer cells by activating the PI3K/AKT/mTOR signaling pathway

Guangchuan Mu, Kaiyan Li, Chaozhen Hu, Jintao Cai, Huichao Ruan, Guanyu Zhu, Dang Liu
Article Number: 48
Published online on: 19 January 2026

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Article Open Access

HMBOX1 inhibits hepatocellular carcinoma progression via PTPN1 mediated AKT1 phosphorylation

Chenning Zhang, Yu Jiang, Jiahui Liu, Wenyu Zhang, Jie Qi, Qing Wen, Hengli Zhao
Article Number: 47
Published online on: 19 January 2026

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Retraction Open Access

[Retracted] Prognostic significance of miR‑218 in human hepatocellular carcinoma and its role in cell growth

Kangsheng Tu, Chao Li, Xin Zheng, Wei Yang, Yingmin Yao, Qingguang Liu
Article Number: 46
Published online on: 19 January 2026

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Review Open Access

Tumor microenvironment in bone sarcomas: Implications for immunotherapy and emerging therapeutic vulnerabilities (Review)

Wentao Li, Lijun Lv, Yibin Jin, Xin Yuan
Article Number: 45
Published online on: 16 January 2026

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Review Open Access

Immunotherapy after EGFR‑TKI treatment in advanced non‑small cell lung cancer: Current status and future perspectives (Review)

Huiyuan Ma, Longhui Li, Conghan Jiao, Yanyan Cheng, Jiayu He, Chen Jiang, Qian Tong, Dan Yi, Ying Zhang
Article Number: 44
Published online on: 16 January 2026

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Correction Open Access

[Corrigendum] Triptolide inhibits JAK2/STAT3 signaling and induces lethal autophagy through ROS generation in cisplatin‑resistant SKOV3/DDP ovarian cancer cells

Yanying Zhong, Fuyin Le, Jiao Cheng, Chen Luo, Xiali Zhang, Xingwu Wu, Fang Xu, Qi Zuo, Buzhen Tan
Article Number: 43
Published online on: 13 January 2026

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Review Open Access

Role of tumor‑infiltrating lymphocytes and miR‑155 in breast cancer: Insights into carcinogenesis and their potential as prognostic biomarkers (Review)

Miriam Monteiro Alvares‑Vilela, Franciele Schlemmer, Sabrina Simplício de Araújo Romero Ferrari, Mary-Ann Elvina Xavier, Ricardo Titze‑de‑Almeida
Article Number: 42
Published online on: 14 January 2026

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Article Open Access

CDK1 depletion suppresses glioma malignancy through cell cycle pathway regulation: Mechanistic insights from functional and molecular profiling

Yu Wang, Huandi Zhou, Xuetao Han, Dongdong Zhang, Liubing Hou, Haonan Li, Tianyi Fan, Sijie Li, Xiaoying Xue
Article Number: 41
Published online on: 12 January 2026

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Retraction Open Access

[Retracted] Downregulated microRNA‑200a promotes EMT and tumor growth through the Wnt/β‑catenin pathway by targeting the E‑cadherin repressors ZEB1/ZEB2 in gastric adenocarcinoma

Ningning Cong, Ping Du, Anling Zhang, Fajuan Shen, Juan Su, Peiyu Pu, Tao Wang, Jie Zjang, Chunsheng Kang, Qingyu Zhang
Article Number: 40
Published online on: 12 January 2026

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Review Open Access

Advances in targeting KRAS mutations: A promising approach for the treatment of non‑small cell lung cancer (Review)

Upesh Sharma, Jincheng Song, Hemraj Kandu, Yue Zhu, Zhaoxia Dai
Article Number: 39
Published online on: 08 January 2026

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Correction Open Access

[Corrigendum] CXCR6 predicts poor prognosis in gastric cancer and promotes tumor metastasis through epithelial-mesenchymal transition

Jie-Jie Jin, Fa-Xiang Dai, Zi-Wen Long, Hong Cai, Xiao-Wen Liu, Ye Zhou, Qi Hong, Qiong-Zhu Dong, Ya-Nong Wang, Hua Huang
Article Number: 38
Published online on: 05 January 2026

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Journal Cover
April-2026 Volume 55 Issue 4

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review

Impact of the intratumoral resident microbiome on the immune microenvironment of malignant tumors (Review)

Han Na Oh, Hoon Hur
Article Number: 66
Published online on: 06 February 2026

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Correction Open Access

[Corrigendum] Hypoxia and macrophages promote glioblastoma invasion by the CCL4‑CCR5 axis

Ying Wang, Tao Liu, Ning Yang, Shuo Xu, Xingang Li, Donghai Wang
Article Number: 65
Published online on: 04 February 2026

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Review Open Access

Origin dictates function: The dual roles of exosomes derived from diverse origins in the onset and progression of colorectal cancer (Review)

Zhao Guo, Haoyan Zhuang, Qingfeng Liu
Article Number: 64
Published online on: 03 February 2026

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Article Open Access

Quercetin reduces expression of ATP‑binding cassette transporters by regulating the PTEN/PI3K/AKT signaling pathway in breast cancer cells

Wentao Fu, Leying Lin, Jie Li, Fei Qin, Chuan Chen, Yinglian Cai, Yilun Cai, Yiling Huang, Wang Yang, Shanshan Zhu
Article Number: 63
Published online on: 02 February 2026

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Article Open Access

POSTN+ fibroblast‑secreted small extracellular vesicles drive macrophage M2 polarization through BMP4/BMPR2/Smad signaling

Chenyang Zhang, Si Chen, Chenghui Qian, Wanqi Lv, Qian Zhang, Yanjin Wang, Yuqiong Wu, Xue Liu
Article Number: 62
Published online on: 02 February 2026

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Retraction Open Access

[Retracted] EGFR/HER2 inhibitors effectively reduce the malignant potential of MDR breast cancer evoked by P‑gp substrates in vitro and in vivo

Yiting Jin, Wei Zhang, Hongying Wang, Zijing Zhang, Chengyu Chu, Xiuping Liu, Qiang Zou
Article Number: 61
Published online on: 02 February 2026

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Article

Tumor‑associated glucocorticoid inhibition by mifepristone reduces polymorphonuclear myeloid‑derived suppressor cells and promotes antitumor immunity in triple‑negative breast cancer‑bearing mice

Masato Kobayashi, Chisana Konno, Ayato Shimizu, Masanori Kobayashi, Tatsuya Hori
Article Number: 60
Published online on: 30 January 2026

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Review Open Access

Mitochondria in T‑cell tumor immunity and tumor therapies targeting mitochondria (Review)

Minjie Zhou, Yijie Xie, Zhipeng Liu, Yi He, Yibing Yin, Keyu Chen, Zhengyu Zhao, Chengshun Zhang, Dingjun Cai
Article Number: 59
Published online on: 29 January 2026

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Article Open Access

TRIM46 deficiency‑induced DNA damage enhances the sensitivity of cisplatin in non‑small cell lung cancer by regulating the Akt signaling pathway

Song Jin, Dandan Zhang, Zhicheng Liao, Lingpei Yu, Yuanyuan Wang, Pengcheng Jia, Minmin Pan, Yifan Li, Jizhou Zhang
Article Number: 58
Published online on: 28 January 2026

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Advances in isolation and detection technologies and immunotherapy applications of circulating tumor cells (Review)

Ping Zhou, Qin Ye, Yiyun Huang, Yumei Feng, Li Zhou, Ke Xie
Article Number: 57
Published online on: 28 January 2026

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[Corrigendum] 3‑Bromopyruvate sensitizes human breast cancer cells to TRAIL‑induced apoptosis via the phosphorylated AMPK‑mediated upregulation of DR5

Yuzhong Chen, Li Wei, Xiaojing Zhang, Xianfu Liu, Yansong Chen, Song Zhang, Lanzhu Zhou, Qixiang Li, Qiong Pan, Surong Zhao, Hao Liu
Article Number: 56
Published online on: 28 January 2026

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