It is possible that tumour-infiltrating granulocytes promote tumour progression

Liu,Huanran; Ubukata,Hideyuki; Tabuchi,Takanobu; Takemura,Akira; Motohashi,Gyou; Nishimura,Motoi; Satani,Tetsuro; Hong,Jianwei; Katano,Motonobu; Nakada,Ichiro; Saniabadi,Abbi R.; Tabuchi,Takafumi

doi:10.3892/or_00000402

July 2009 Volume 22 Issue 1

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July 2009 Volume 22 Issue 1

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Article

It is possible that tumour-infiltrating granulocytes promote tumour progression

Authors:
- Huanran Liu
- Hideyuki Ubukata
- Takanobu Tabuchi
- Akira Takemura
- Gyou Motohashi
- Motoi Nishimura
- Tetsuro Satani
- Jianwei Hong
- Motonobu Katano
- Ichiro Nakada
- Abbi R. Saniabadi
- Takafumi Tabuchi
View Affiliations / Copyright

Affiliations: Fourth Department of Surgery, Tokyo Medical University, Kasumigaura Hospital, Ibaragi 300-0395, Japan. lhrlhr9050@yahoo.com
Pages: 29-33
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Published online on: July 1, 2009

https://doi.org/10.3892/or_00000402
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Abstract

Several lines of evidence indicate that tumour-infiltrating granulocytes (TIGs) promote tumour growth and progression. However, the prognostic significance of TIGs, the relationship beween TIGs and Fas ligand (FasL) expressed on tumour cells remains unclear and warrants investigation. Using immunnostaining, we retrospectively investigated TIGs and FasL in 130 tissue specimens from gastric carcinoma. We analyzed the correlation among these markers, their association with clinicopathologic features and prognosis. The number of TIGs was significantly associated with FasL-expression (P=0.002). Further, TIGs were significantly associated with depth of tumour invasion, lymph node metastasis and tumour stage. Calculating the prognostic relevance, in multivariate analysis, TIGs [relative risk (RR)=1.014; 95% CI=1.002-1.027; P=0.015] and tumour stage were statistically significant factors for survival. Our results suggest that TIGs are conveniently measured by the immunostaining method, and possibly serve as an independent factor of prognosis in patients with gastric carcinoma. This is based on the fact that TIGs were significantly associated with tumour stage and shorter survival time.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

It is possible that tumour-infiltrating granulocytes promote tumour progression

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Abstract

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