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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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September 2009 Volume 22 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 2009 Volume 22 Issue 3

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Article

Genistein inhibits growth of human uveal melanoma cells and affects microRNA-27a and target gene expression

  • Authors:
    • Qingmin Sun
    • Rihong Cong
    • Hongli Yan
    • Haijuan Gu
    • Ying Zeng
    • Nannan Liu
    • Jie Chen
    • Bin Wang

  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology, Nanjing Medical University, Jiangsu Province 210029, P.R. China
  • Pages: 563-567
    |
    Published online on: September 1, 2009
       https://doi.org/10.3892/or_00000472
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Abstract

Genistein, an isoflavone isolated from soybean, has been found to be a potent antitumor agent. However, both the effect of genistein on human uveal melanoma cells and the precise mechanism by which genistein suppresses tumorigenesis remain unclear. In the present study, we explored the possible activity of genistein to inhibit human uveal melanoma cell growth and investigated the possible role of genistein on microRNA-27a (miR-27a) as well as its target gene zinc finger and BTB domain containing 10 (ZBTB10) expression levels. The results suggested a significant inhibition of uveal melanoma cell growth in a time- and dose-related manner. In vivo study also indicated treatment groups with genistein could significantly inhibit the growth of xenografts. Further functional assays revealed that the levels of miR-27a and its target gene ZBTB10 were significantly different based on the dose of genistein. In conclusion, the present study demonstrates that genistein exerts growth inhibitory activities in human uveal melanoma cells. Moreover, we for the first time report a correlation between antitumor activity of genistein and miR-27a mediated regulatory mechanism.

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Copy and paste a formatted citation
Spandidos Publications style
Sun Q, Cong R, Yan H, Gu H, Zeng Y, Liu N, Chen J and Wang B: Genistein inhibits growth of human uveal melanoma cells and affects microRNA-27a and target gene expression. Oncol Rep 22: 563-567, 2009.
APA
Sun, Q., Cong, R., Yan, H., Gu, H., Zeng, Y., Liu, N. ... Wang, B. (2009). Genistein inhibits growth of human uveal melanoma cells and affects microRNA-27a and target gene expression. Oncology Reports, 22, 563-567. https://doi.org/10.3892/or_00000472
MLA
Sun, Q., Cong, R., Yan, H., Gu, H., Zeng, Y., Liu, N., Chen, J., Wang, B."Genistein inhibits growth of human uveal melanoma cells and affects microRNA-27a and target gene expression". Oncology Reports 22.3 (2009): 563-567.
Chicago
Sun, Q., Cong, R., Yan, H., Gu, H., Zeng, Y., Liu, N., Chen, J., Wang, B."Genistein inhibits growth of human uveal melanoma cells and affects microRNA-27a and target gene expression". Oncology Reports 22, no. 3 (2009): 563-567. https://doi.org/10.3892/or_00000472
Copy and paste a formatted citation
x
Spandidos Publications style
Sun Q, Cong R, Yan H, Gu H, Zeng Y, Liu N, Chen J and Wang B: Genistein inhibits growth of human uveal melanoma cells and affects microRNA-27a and target gene expression. Oncol Rep 22: 563-567, 2009.
APA
Sun, Q., Cong, R., Yan, H., Gu, H., Zeng, Y., Liu, N. ... Wang, B. (2009). Genistein inhibits growth of human uveal melanoma cells and affects microRNA-27a and target gene expression. Oncology Reports, 22, 563-567. https://doi.org/10.3892/or_00000472
MLA
Sun, Q., Cong, R., Yan, H., Gu, H., Zeng, Y., Liu, N., Chen, J., Wang, B."Genistein inhibits growth of human uveal melanoma cells and affects microRNA-27a and target gene expression". Oncology Reports 22.3 (2009): 563-567.
Chicago
Sun, Q., Cong, R., Yan, H., Gu, H., Zeng, Y., Liu, N., Chen, J., Wang, B."Genistein inhibits growth of human uveal melanoma cells and affects microRNA-27a and target gene expression". Oncology Reports 22, no. 3 (2009): 563-567. https://doi.org/10.3892/or_00000472
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