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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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October 2009 Volume 22 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article Open Access

A scoring system for histopathologic and immunohistochemical evaluations of uterine leiomyosarcomas

  • Authors:
    • Chika Yoshida
    • Tomoyuki Ichimura
    • Naoki Kawamura
    • Akemi Nakano
    • Mari Kasai
    • Toshiyuki Sumi
    • Osamu Ishiko

  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan. c-yoshida@med.osaka-cu.ac.jp
  • Pages: 725-731
    |
    Published online on: October 1, 2009
       https://doi.org/10.3892/or_00000493
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Abstract

Uterine leiomyosarcomas (LMS) are difficult to distinguish from benign leiomyomas without surgery. In this study we performed transcervical needle biopsy on 475 patients, 8 LMS patients and 467 patients with non-sarcomas (non-LMS) in a high-risk group for LMS, and evaluated whether examinations performed with Ki-67 and CD34 immunohistochemical analyses in addition to the standard hematoxylin-eosin (H&E)-stained sections would improve preoperative diagnostic precision of the uterine smooth muscle tumors. Histopathologic analysis included three factors: degree of cytologic atypia, mitotic index and coagulative tumor cell necrosis (CTCN). We also evaluated cell proliferation with Ki-67 expression. In cases of suspected CTCN, we examined CD34 expression and counted positive blood vessels in the necrotic area. Three of the 8 LMS cases satisfied the diagnostic criteria of LMS by histopathologic evaluation with H&E-stained sections. We made a score list based on these analyses; scores for LMS specimens ranged from 6-14 points; non-LMS specimens scored 0-2 points. At the cut-off score of 6 points, the positive predictive value to distinguish LMS from non-LMS was 100%, showing that this scoring system, is a useful method for preoperative differentiation between LMS and non-LMS tumors.

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Copy and paste a formatted citation
Spandidos Publications style
Yoshida C, Ichimura T, Kawamura N, Nakano A, Kasai M, Sumi T and Ishiko O: A scoring system for histopathologic and immunohistochemical evaluations of uterine leiomyosarcomas. Oncol Rep 22: 725-731, 2009.
APA
Yoshida, C., Ichimura, T., Kawamura, N., Nakano, A., Kasai, M., Sumi, T., & Ishiko, O. (2009). A scoring system for histopathologic and immunohistochemical evaluations of uterine leiomyosarcomas. Oncology Reports, 22, 725-731. https://doi.org/10.3892/or_00000493
MLA
Yoshida, C., Ichimura, T., Kawamura, N., Nakano, A., Kasai, M., Sumi, T., Ishiko, O."A scoring system for histopathologic and immunohistochemical evaluations of uterine leiomyosarcomas". Oncology Reports 22.4 (2009): 725-731.
Chicago
Yoshida, C., Ichimura, T., Kawamura, N., Nakano, A., Kasai, M., Sumi, T., Ishiko, O."A scoring system for histopathologic and immunohistochemical evaluations of uterine leiomyosarcomas". Oncology Reports 22, no. 4 (2009): 725-731. https://doi.org/10.3892/or_00000493
Copy and paste a formatted citation
x
Spandidos Publications style
Yoshida C, Ichimura T, Kawamura N, Nakano A, Kasai M, Sumi T and Ishiko O: A scoring system for histopathologic and immunohistochemical evaluations of uterine leiomyosarcomas. Oncol Rep 22: 725-731, 2009.
APA
Yoshida, C., Ichimura, T., Kawamura, N., Nakano, A., Kasai, M., Sumi, T., & Ishiko, O. (2009). A scoring system for histopathologic and immunohistochemical evaluations of uterine leiomyosarcomas. Oncology Reports, 22, 725-731. https://doi.org/10.3892/or_00000493
MLA
Yoshida, C., Ichimura, T., Kawamura, N., Nakano, A., Kasai, M., Sumi, T., Ishiko, O."A scoring system for histopathologic and immunohistochemical evaluations of uterine leiomyosarcomas". Oncology Reports 22.4 (2009): 725-731.
Chicago
Yoshida, C., Ichimura, T., Kawamura, N., Nakano, A., Kasai, M., Sumi, T., Ishiko, O."A scoring system for histopathologic and immunohistochemical evaluations of uterine leiomyosarcomas". Oncology Reports 22, no. 4 (2009): 725-731. https://doi.org/10.3892/or_00000493
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