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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
October 2009 Volume 22 Issue 4

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Journal Metrics

Impact Factor: 4.7

CiteScore: 7.7

CiteScore Rank: Q1: #76/428 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review

Targeting of the BRAF gene in papillary thyroid carcinoma (Review)

Yaqiong Li, Misa Nakamura, Kennichi Kakudo
Pages: 671-681
Published online on: 01 October 2009

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Article

Epidermal growth factor receptor and K-RAS mutations in 411 lung adenocarcinoma: A population-based prospective study

Laura Boldrini, Greta Alì, Silvia Gisfredi, Silvia Ursino, Editta Baldini, Franca Melfi, Marco Lucchi, Camilla E. Comin, Cristina Maddau, Carmelo Tibaldi, Tiziano Camacci, Adele Servadio, Alfredo Mussi, Gabriella Fontanini
Pages: 683-691
Published online on: 01 October 2009

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Article

Hypoxia-inducible factor-1α expression predicts the response to 5-fluorouracil-based adjuvant chemotherapy in advanced gastric cancer

Jun Nakamura, Yoshihiko Kitajima, Keita Kai, Mayumi Mitsuno, Takao Ide, Kazuyoshi Hashiguchi, Masatsugu Hiraki, Kohji Miyazaki
Pages: 693-699
Published online on: 01 October 2009

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Article

Combination treatment of Cetuximab and photodynamic therapy in SNU-1041 squamous cancer cell line

Sun Gon Kim, Ji Won Hong, Sung Hyun Boo, Myung Gu Kim, Kang Dae Lee, Jin Chul Ahn, Hee Jun Hwang, Jang-In Shin, Sang Joon Lee, Jang Keun Oh, Phil Sang Chung
Pages: 701-708
Published online on: 01 October 2009

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Article

Elevated CD133, but not VEGF or EGFR, as a predictive marker of distant recurrence after preoperative chemoradiotherapy in rectal cancer

Hiromi Yasuda, Koji Tanaka, Susumu Saigusa, Yuji Toiyama, Yuhki Koike, Yoshinaga Okugawa, Takeshi Yokoe, Aya Kawamoto, Yasuhiro Inoue, Chikao Miki, Masato Kusunoki
Pages: 709-717
Published online on: 01 October 2009

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Article

S-1 mediates the inhibition of lymph node metastasis in oral cancer cells

Hana Sato, Masashi Hatori, Yuriko Ando, Yuji Kurihara, Sayaka Takayama, Tatsuo Shirota, Tetsuhiko Tachikawa, Satoru Shintani
Pages: 719-724
Published online on: 01 October 2009

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Article Open Access

A scoring system for histopathologic and immunohistochemical evaluations of uterine leiomyosarcomas

Chika Yoshida, Tomoyuki Ichimura, Naoki Kawamura, Akemi Nakano, Mari Kasai, Toshiyuki Sumi, Osamu Ishiko
Pages: 725-731
Published online on: 01 October 2009

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Article

Aberrant expression of class III β-tubulin in basal cell carcinoma of the skin

Mitsuaki Ishida, Ryoji Kushima, Hidetoshi Okabe
Pages: 733-737
Published online on: 01 October 2009

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Article Open Access

Novel anti-cancer compounds: Structure-based discovery of chemical chaperons for p53

Yumiko Okuda, Hironori K. Nakamura, Kazuo Kuwata
Pages: 739-744
Published online on: 01 October 2009

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Article

CD44v6, MMP-7 and nuclear Cdx2 are significant biomarkers for prediction of lymph node metastasis in primary gastric cancer

Hirokazu Okayama, Kensuke Kumamoto, Katsuharu Saitou, Suguru Hayase, Yasuhide Kofunato, Yu Sato, Kotaro Miyamoto, Izumi Nakamura, Shinji Ohki, Kouji Sekikawa, Seiichi Takenoshita
Pages: 745-755
Published online on: 01 October 2009

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Article

PTEN expression and mutation in colorectal carcinomas

Xiao-Han Li, Hua-Chuan Zheng, Hiroyuki Takahashi, Shinji Masuda, Xiang-Hong Yang, Yasuo Takano
Pages: 757-764
Published online on: 01 October 2009

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Article

Enhanced radiosensitivity of SW480 cells via TRAIL up-regulation mediated by Egr-1 promoter

Y. Hu, W. Ouyang, F. Wu, C. H. Cao, K. Wang, Z. K. Liao, Y. H. Zhong, F. X. Zhou, S. Q. Liu, L. Xia, Y. F. Zhou, C. H. Xie
Pages: 765-771
Published online on: 01 October 2009

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Article

Promoter methylation and expression analysis of MGMT in advanced pediatric brain tumors

Iacopo Sardi, Valentina Cetica, Maura Massimino, Anna Maria Buccoliero, Laura Giunti, Lorenzo Genitori, Maurizio Aricò
Pages: 773-779
Published online on: 01 October 2009

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Article

Effect of CD133/prominin-1 antisense oligodeoxynucleotide on in vitro growth characteristics of Huh-7 human hepatocarcinoma cells and U251 human glioma cells

Jie Yao, Tao Zhang, Jinghua Ren, Minxia Yu, Gang Wu
Pages: 781-787
Published online on: 01 October 2009

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Article

Ninein-like protein is overexpressed in head and neck squamous cell carcinoma and contributes to cancer growth and resistance to apoptosis

Linlin Yu, Yongmei Song, Qiuhang Zhang, Qimin Zhan
Pages: 789-798
Published online on: 01 October 2009

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Article

Differential expression of the LOX family genes in human colorectal adenocarcinomas

Youngho Kim, Seonae Roh, Jung-Young Park, Yangsik Kim, Dong Hyung Cho, Jin Cheon Kim
Pages: 799-804
Published online on: 01 October 2009

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Article Open Access

Gene expression profile of residual breast cancer after doxorubicin and cyclophosphamide neoadjuvant chemotherapy

Maria Aparecida Azevedo Koike Folgueira, Helena Brentani, Dirce Maria Carraro, Mateus De Camargo Barros Filho, Maria Lucia Hirata Katayama, Ana Paula Santana de Abreu, Edson Mantovani Barbosa, Célia Tosello De Oliveira, Diogo F.C. Patrão, Louise D. Mota, Mario Mourão Netto, José Roberto Figaro Caldeira, Maria Mitzi Brentani
Pages: 805-813
Published online on: 01 October 2009

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Article

Potential role of Notch1 signaling pathway in laryngeal squamous cell carcinoma cell line Hep-2 involving proliferation inhibition, cell cycle arrest, cell apoptosis, and cell migration

Jing Jiao, Zhaobing Qin, Sha Li, Hongtao Liu, Zhaoming Lu
Pages: 815-823
Published online on: 01 October 2009

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Article

Norepinephrine-induced invasion by pancreatic cancer cells is inhibited by propranolol

Kun Guo, Qingyong Ma, Liancai Wang, Hengtong Hu, Junhui Li, Dong Zhang, Min Zhang
Pages: 825-830
Published online on: 01 October 2009

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Article

MycN is a transcriptional regulator of livin in neuroblastoma

Anindya Dasgupta, Susan K. Peirce, Harry W. Findley
Pages: 831-835
Published online on: 01 October 2009

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Article

FoxO3a gene is a target of deletion in mouse lung adenocarcinoma

Christopher R. Herzog, Daniel C. Blake, Oliver R. Mikse, Lubov S. Grigoryeva, Erica L. Gundermann
Pages: 837-843
Published online on: 01 October 2009

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Article

In vitro anti-neoplastic activity of the ethno-pharmaceutical plant Hypericum adenotrichum Spach endemic to Western Turkey

Ali Özmen, Sabine Bauer, Manuela Gridling, Judith Singhuber, Stanimira Krasteva, Sibylle Madlener, Than Phuong Nha Vo, Nicole Stark, Philipp Saiko, Monika Fritzer-Szekeres, Thomas Szekeres, Tülay Askin-Celik, Liselotte Krenn, Georg Krupitza
Pages: 845-852
Published online on: 01 October 2009

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Article

Identification of candidate epigenetic biomarkers for ovarian cancer detection

Yi-Wen Huang, Rachel A. Jansen, Enrica Fabbri, Dustin Potter, Sandya Liyanarachchi, Michael W.Y. Chan, Joseph C. Liu, Anne P.G. Crijns, Robert Brown, Kenneth P. Nephew, Ate G.J. van der Zee, David E. Cohn, Pearlly S. Yan, Tim H.-M. Huang, Huey-Jen L. Lin
Pages: 853-861
Published online on: 01 October 2009

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Article

Identification of specific microRNAs responding to low and high dose γ-irradiation in the human lymphoblast line IM9

Hwa Jun Cha, Ki Moon Seong, Seunghee Bae, Jin Hyuk Jung, Cha Soon Kim, Kwang-Hee Yang, Young-Woo Jin, Sungkwan An
Pages: 863-868
Published online on: 01 October 2009

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Article

Increased sensitivity to platinating agents and arsenite in human ovarian cancer by downregulation of ASNA1

Oskar Hemmingsson, Mikael Nöjd, Gautam Kao, Peter Naredi
Pages: 869-875
Published online on: 01 October 2009

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Article

A pilot study of Auron Misheil Therapy in patients with advanced cervical cancer: Tumor response and its correlation with clinical benefit response, and preliminary quality of life data

Jürgen Scheele, Faiz Niazi, Joachim Drevs, Klaus Diergarten, Papa Toure
Pages: 877-883
Published online on: 01 October 2009

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Article

Long-term results of radiofrequency ablation in colorectal lung metastases: Single center experience

Koichiro Yamakado, Yasuhiro Inoue, Motoshi Takao, Haruyuki Takaki, Atsuhiro Nakatsuka, Junji Uraki, Masataka Kashima, Masato Kusunoki, Hideto Shimpo, Kan Takeda
Pages: 885-891
Published online on: 01 October 2009

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Article

Efficacy of hybrid 2-port hand-assisted laparoscopic surgery (Mukai's operation) for patients with primary colorectal cancer

Masaya Mukai, Kyoko Kishima, Takayuki Tajima, Tatsuhiko Hoshikawa, Naoki Yazawa, Hiroshi Fukumitsu, Kazutake Okada, Kyouji Ogoshi, Hiroyasu Makuuchi
Pages: 893-899
Published online on: 01 October 2009

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Article

Microdissection is essential for gene expression analysis of irradiated rectal cancer tissues

Yasuhiro Inoue, Koji Tanaka, Takeshi Yokoe, Susumu Saigusa, Yuji Toiyama, Chikao Miki, Masato Kusunoki
Pages: 901-906
Published online on: 01 October 2009

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Article

Underexpression of PPARγ is associated with aneuploidy and lower differentiation of thyroid tumours of follicular origin

Carla Espadinha, António E. Pinto, Valeriano Leite
Pages: 907-913
Published online on: 01 October 2009

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Article

The antitumor immune responses induced by nanoemulsion-encapsulated MAGE1-HSP70/SEA complex protein vaccine following different administration routes

Wei Ge, Pei-Zhen Hu, Yang Huang, Xiao-Ming Wang, Xiu-Min Zhang, Yu-Jing Sun, Zeng-Shan Li, Shao-Yan Si, Yan-Fang Sui
Pages: 915-920
Published online on: 01 October 2009

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Article

Facilitation of drug resistance development by γ-irradiation in human cancer cells

Tsun Yee Tsang, Sze Wing Tsang, Ka Po Lai, Wing Pui Tsang, Ngai Na Co, Tim Tak Kwok
Pages: 921-926
Published online on: 01 October 2009

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Article

Clues pointing to simple hysterectomy to treat early-stage cervical cancer

Charles Coutant, Anne Gaël Cordier, Eric Guillo, Marcos Ballester, Roman Rouzier, Emile Daraï
Pages: 927-934
Published online on: 01 October 2009

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Article Open Access

Toll-like receptor 9 agonist inhibits ERα-mediated transactivation by activating NF-κB in breast cancer cell lines

Jianming Qiu, Xiaojian Wang, Xinhai Guo, Chenyin Zhao, Xuhui Wu, Yongkui Zhang
Pages: 935-941
Published online on: 01 October 2009

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Article

American ginseng berry enhances chemopreventive effect of 5-FU on human colorectal cancer cells

Xiao-Li Li, Chong-Zhi Wang, Shi Sun, Sangeeta R. Mehendale, Wei Du, Tong-Chuan He, Chun-Su Yuan
Pages: 943-952
Published online on: 01 October 2009

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Article

Human HSP70 and modified HPV16 E7 fusion DNA vaccine induces enhanced specific CD8+ T cell responses and anti-tumor effects

Jinbao Zong, Qinglin Peng, Qingyong Wang, Ting Zhang, Dongsheng Fan, Xuemei Xu
Pages: 953-961
Published online on: 01 October 2009

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Journal Cover
September-2026 Volume 56 Issue 3

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Journal Metrics

Impact Factor: 4.7

CiteScore: 7.7

CiteScore Rank: Q1: #76/428 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Article Open Access

Polyphyllin II inhibits thyroid cancer progression by targeting HRH1 and suppressing Wnt/β‑catenin signaling

Jianwei Sun, Haifeng Liang, Yan Zhang, Ding Ding, Qian Xiang, Mengyang Zheng, Pengyue Zhang
Article Number: 163
Published online on: 23 July 2026

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Review Open Access

Multidimensional molecular mechanisms of drug resistance in breast cancer: Implications for clinical decision‑making and treatment strategies (Review)

Wenya Xu, Shiyao Kang, Shaochen Xin, Yanbin Wu, Yuan Zhao, Miaomiao Sheng
Article Number: 162
Published online on: 22 July 2026

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Review Open Access

XPO1: From basic research to clinical treatment (Review)

Changyan Yang, Jing Zhu, Xiang Zheng, Xiaochen Hou, Jiumei Zhao, Youfu Pan, Yu Tang
Article Number: 161
Published online on: 22 July 2026

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Retraction Open Access

[Retracted] Methylation and intratumoural heterogeneity of 14‑3‑3 σ in oral cancer

Ujjal Kumar Bhawal, Keiichi Tsukinoki, Tomonori Sasahira, Fuyuki Sato, Yusuke Mori, Noriko Muto, Masaru Sugiyama, Hiroki Kuniyasu
Article Number: 160
Published online on: 20 July 2026

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Article Open Access

M2‑TAM‑derived exosomal miR‑491‑3p modulates UBE2D3 and promotes the proliferation, migration and invasion of lung cancer cells

Qiang Zhang, Yungang Sun, Yu Zhuang, Shiwei Xu, Mengxu Yao, Siyang Jiao, Qi Wang, Feng Shao, Xiaoying Zhang
Article Number: 159
Published online on: 17 July 2026

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Correction Open Access

[Corrigendum] Emodin attenuated severe acute pancreatitis via the P2X ligand‑gated ion channel 7/NOD‑like receptor protein 3 signaling pathway

Qingkai Zhang, Xufeng Tao, Shilin Xia, Jialin Qu, Huiyi Song, Jianjun Liu, Hailong Li, Dong Shang
Article Number: 158
Published online on: 15 July 2026

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Article Open Access

TM6SF2 overexpression suppresses the proliferation and promotes apoptosis of human hepatocellular carcinoma cells

Ziyou Huai, Wanying Xue, Xinxiao Jin, Shiyu Peng, Wenqiang Xu, Shujing Li, Huanfeng Hao, Yuanyuan Wang
Article Number: 157
Published online on: 14 July 2026

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Correction Open Access

[Corrigendum] VDAC upregulation and αTAT1‑mediated α‑tubulin acetylation contribute to tanespimycin‑induced apoptosis in Calu‑1 cells

Qilin Wang, Xiangguo Liu
Article Number: 156
Published online on: 13 July 2026

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Retraction Open Access

[Retracted] Synergistic cytotoxic effects of inorganic phosphate and chemotherapeutic drugs on human osteosarcoma cells

Annamaria Spina, Luca Sorvillo, Emilio Chiosi, Antonietta Esposito, Francesca Di Maiolo, Luigi Sapio, Michele Caraglia, Silvio Naviglio
Article Number: 155
Published online on: 06 July 2026

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Article Open Access

Identification of RRM2 as a key regulator of malignant epithelial cells in gastric cancer through single‑cell transcriptomics

Xinzhen Cai, Yun He, Lili Kang, Dongli Zhou, Mengmeng Wang, Tianyu Ma
Article Number: 154
Published online on: 03 July 2026

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Article

Impact of WFDC2 on the biological functions of cervical cancer cells and the regulation of the ERK/NF‑κB signaling pathway

Yanping Zhang, Hongling Zou, Shufeng Deng, Lvling Zou, Mingzhu Xia, Limin Tao
Article Number: 153
Published online on: 01 July 2026

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Journal Cover
October-2026 Volume 56 Issue 4

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Journal Metrics

Impact Factor: 4.7

CiteScore: 7.7

CiteScore Rank: Q1: #76/428 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

Genomic instability, postoperative recurrence and therapeutic vulnerabilities in resectable non‑small cell lung cancer (Review)

Linlin Wang, Yong Feng, Qiang Liu
Article Number: 182
Published online on: 28 August 2026

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Review Open Access

Research progress on lactate metabolism in lung cancer: Tumorigenesis, drug resistance and clinical translation (Review)

Yuantao Zhang, Yiyang Shang, Hai Zeng, Ruiling Ning, Xinran Zhang, Dongxu Ao, Jun Cai, Qingqing Ye
Article Number: 181
Published online on: 28 August 2026

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Review Open Access

Decoding the metabolic‑immune crosstalk: The role of glutamine and ammonium reprogramming in prostate cancer immune evasion (Review)

Peilong Wang, Xiaoran Li, Teng Ma, Jun Mi
Article Number: 180
Published online on: 27 August 2026

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Expression of Concern Open Access

[Expression of Concern] Inhibition of TMEM45A suppresses proliferation, induces cell cycle arrest and reduces cell invasion in human ovarian cancer cells

Jing Guo, Li Chen, Ning Luo, Weihong Yang, Xiaoyan Qu, Zhongping Cheng
Article Number: 179
Published online on: 24 August 2026

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Article Open Access

Combination of lonidamine with devimistat induces synergistic antitumor effects in lung cancer via multifaceted disruption of cellular energy metabolism

Xinhe Bai, Yongfeng Yang, Yuling Luo, Pei Jing, Xia Hong, Yaqin Zou, Yan Dai, Xuping Yang, Meiling Zhou, Han Xiao, Yilan Huang, Shiwei Guo, Qingze Fan
Article Number: 178
Published online on: 20 August 2026

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Correction Open Access

[Corrigendum] Targeting ribonucleotide reductase M2 subunit by small interfering RNA exerts anti‑oncogenic effects in gastric adenocarcinoma 

Wei Kang, Joanna H.M. Tong, Anthony W.H. Chan, Junhong Zhao, Shiyan Wang, Yujuan Dong, Frankie M.C. Sin, Saifung Yeung, Alfred S.L. Cheng, Jun Yu, Kafai To
Article Number: 177
Published online on: 20 August 2026

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Article Open Access

Cancer‑associated fibroblast‑derived extracellular vesicles promote pancreatic cancer progression via the RAP1B/ANLN axis

Daigo Yoshimori, Mitsuhiro Kudo, Kousuke Ishino, Junji Ueda, Yukako Shintani-Domoto, Akira Matsushita, Youichi Kawano, Takashi Ono, Takahiro Haruna, Kazuhiko Endo, Akira Hamaguchi, Takenori Fujii, Yoko Kawamoto, Kiyoshi Teduka, Taeko Kitamura, Atsushi Masamune, Akihisa Matsuda, Hiroshi Yoshida, Ryuji Ohashi
Article Number: 176
Published online on: 18 August 2026

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Retraction Open Access

[Retracted] Restoration of the tumor‑suppressor function to mutant p53 by Ganoderma lucidum polysaccharides in colorectal cancer cells

Dan Jiang, Lingyao Wang, Tong Zhao, Zhaoyu Zhang, Renxia Zhang, Jingji Jin, Yong Cai, Fei Wang
Article Number: 175
Published online on: 17 August 2026

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Review Open Access

Molecular classification and precision therapy in gastric cancer: Current advances and future perspectives (Review)

Shujing Xia, Xiumei Zhang, Lizhong Tang, Anqi Li, Jianhai Chen, Zhang Tao
Article Number: 174
Published online on: 14 August 2026

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Expression of Concern Open Access

[Expression of Concern] Suppression of PTEN/AKT signaling decreases the expression of TUBB3 and TOP2A with subsequent inhibition of cell growth and induction of apoptosis in human breast cancer MCF-7 cells via ATP and caspase-3 signaling pathways

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HDAC1 promotes lung adenocarcinoma progression via the nuclear accumulation of β‑catenin

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Retraction Open Access

[Retracted] MicroRNA‑365 inhibits proliferation, migration and invasion of glioma by targeting PIK3R3

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Stable overexpression of Nup88 enhances HeLa cell migration through independent regulation of Kif7 and Gli1

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TPD54 contributes to docetaxel resistance through modulation of P‑glycoprotein localization and activity in oral squamous cell carcinoma cells

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Published online on: 24 July 2026

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