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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
October 2009 Volume 22 Issue 4

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review

Targeting of the BRAF gene in papillary thyroid carcinoma (Review)

Yaqiong Li, Misa Nakamura, Kennichi Kakudo
Pages: 671-681
Published online on: 01 October 2009

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Article

Epidermal growth factor receptor and K-RAS mutations in 411 lung adenocarcinoma: A population-based prospective study

Laura Boldrini, Greta Alì, Silvia Gisfredi, Silvia Ursino, Editta Baldini, Franca Melfi, Marco Lucchi, Camilla E. Comin, Cristina Maddau, Carmelo Tibaldi, Tiziano Camacci, Adele Servadio, Alfredo Mussi, Gabriella Fontanini
Pages: 683-691
Published online on: 01 October 2009

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Article

Hypoxia-inducible factor-1α expression predicts the response to 5-fluorouracil-based adjuvant chemotherapy in advanced gastric cancer

Jun Nakamura, Yoshihiko Kitajima, Keita Kai, Mayumi Mitsuno, Takao Ide, Kazuyoshi Hashiguchi, Masatsugu Hiraki, Kohji Miyazaki
Pages: 693-699
Published online on: 01 October 2009

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Article

Combination treatment of Cetuximab and photodynamic therapy in SNU-1041 squamous cancer cell line

Sun Gon Kim, Ji Won Hong, Sung Hyun Boo, Myung Gu Kim, Kang Dae Lee, Jin Chul Ahn, Hee Jun Hwang, Jang-In Shin, Sang Joon Lee, Jang Keun Oh, Phil Sang Chung
Pages: 701-708
Published online on: 01 October 2009

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Article

Elevated CD133, but not VEGF or EGFR, as a predictive marker of distant recurrence after preoperative chemoradiotherapy in rectal cancer

Hiromi Yasuda, Koji Tanaka, Susumu Saigusa, Yuji Toiyama, Yuhki Koike, Yoshinaga Okugawa, Takeshi Yokoe, Aya Kawamoto, Yasuhiro Inoue, Chikao Miki, Masato Kusunoki
Pages: 709-717
Published online on: 01 October 2009

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Article

S-1 mediates the inhibition of lymph node metastasis in oral cancer cells

Hana Sato, Masashi Hatori, Yuriko Ando, Yuji Kurihara, Sayaka Takayama, Tatsuo Shirota, Tetsuhiko Tachikawa, Satoru Shintani
Pages: 719-724
Published online on: 01 October 2009

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Article Open Access

A scoring system for histopathologic and immunohistochemical evaluations of uterine leiomyosarcomas

Chika Yoshida, Tomoyuki Ichimura, Naoki Kawamura, Akemi Nakano, Mari Kasai, Toshiyuki Sumi, Osamu Ishiko
Pages: 725-731
Published online on: 01 October 2009

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Article

Aberrant expression of class III β-tubulin in basal cell carcinoma of the skin

Mitsuaki Ishida, Ryoji Kushima, Hidetoshi Okabe
Pages: 733-737
Published online on: 01 October 2009

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Article Open Access

Novel anti-cancer compounds: Structure-based discovery of chemical chaperons for p53

Yumiko Okuda, Hironori K. Nakamura, Kazuo Kuwata
Pages: 739-744
Published online on: 01 October 2009

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Article

CD44v6, MMP-7 and nuclear Cdx2 are significant biomarkers for prediction of lymph node metastasis in primary gastric cancer

Hirokazu Okayama, Kensuke Kumamoto, Katsuharu Saitou, Suguru Hayase, Yasuhide Kofunato, Yu Sato, Kotaro Miyamoto, Izumi Nakamura, Shinji Ohki, Kouji Sekikawa, Seiichi Takenoshita
Pages: 745-755
Published online on: 01 October 2009

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Article

PTEN expression and mutation in colorectal carcinomas

Xiao-Han Li, Hua-Chuan Zheng, Hiroyuki Takahashi, Shinji Masuda, Xiang-Hong Yang, Yasuo Takano
Pages: 757-764
Published online on: 01 October 2009

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Article

Enhanced radiosensitivity of SW480 cells via TRAIL up-regulation mediated by Egr-1 promoter

Y. Hu, W. Ouyang, F. Wu, C. H. Cao, K. Wang, Z. K. Liao, Y. H. Zhong, F. X. Zhou, S. Q. Liu, L. Xia, Y. F. Zhou, C. H. Xie
Pages: 765-771
Published online on: 01 October 2009

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Article

Promoter methylation and expression analysis of MGMT in advanced pediatric brain tumors

Iacopo Sardi, Valentina Cetica, Maura Massimino, Anna Maria Buccoliero, Laura Giunti, Lorenzo Genitori, Maurizio Aricò
Pages: 773-779
Published online on: 01 October 2009

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Article

Effect of CD133/prominin-1 antisense oligodeoxynucleotide on in vitro growth characteristics of Huh-7 human hepatocarcinoma cells and U251 human glioma cells

Jie Yao, Tao Zhang, Jinghua Ren, Minxia Yu, Gang Wu
Pages: 781-787
Published online on: 01 October 2009

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Article

Ninein-like protein is overexpressed in head and neck squamous cell carcinoma and contributes to cancer growth and resistance to apoptosis

Linlin Yu, Yongmei Song, Qiuhang Zhang, Qimin Zhan
Pages: 789-798
Published online on: 01 October 2009

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Article

Differential expression of the LOX family genes in human colorectal adenocarcinomas

Youngho Kim, Seonae Roh, Jung-Young Park, Yangsik Kim, Dong Hyung Cho, Jin Cheon Kim
Pages: 799-804
Published online on: 01 October 2009

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Article Open Access

Gene expression profile of residual breast cancer after doxorubicin and cyclophosphamide neoadjuvant chemotherapy

Maria Aparecida Azevedo Koike Folgueira, Helena Brentani, Dirce Maria Carraro, Mateus De Camargo Barros Filho, Maria Lucia Hirata Katayama, Ana Paula Santana de Abreu, Edson Mantovani Barbosa, Célia Tosello De Oliveira, Diogo F.C. Patrão, Louise D. Mota, Mario Mourão Netto, José Roberto Figaro Caldeira, Maria Mitzi Brentani
Pages: 805-813
Published online on: 01 October 2009

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Article

Potential role of Notch1 signaling pathway in laryngeal squamous cell carcinoma cell line Hep-2 involving proliferation inhibition, cell cycle arrest, cell apoptosis, and cell migration

Jing Jiao, Zhaobing Qin, Sha Li, Hongtao Liu, Zhaoming Lu
Pages: 815-823
Published online on: 01 October 2009

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Article

Norepinephrine-induced invasion by pancreatic cancer cells is inhibited by propranolol

Kun Guo, Qingyong Ma, Liancai Wang, Hengtong Hu, Junhui Li, Dong Zhang, Min Zhang
Pages: 825-830
Published online on: 01 October 2009

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Article

MycN is a transcriptional regulator of livin in neuroblastoma

Anindya Dasgupta, Susan K. Peirce, Harry W. Findley
Pages: 831-835
Published online on: 01 October 2009

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Article

FoxO3a gene is a target of deletion in mouse lung adenocarcinoma

Christopher R. Herzog, Daniel C. Blake, Oliver R. Mikse, Lubov S. Grigoryeva, Erica L. Gundermann
Pages: 837-843
Published online on: 01 October 2009

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Article

In vitro anti-neoplastic activity of the ethno-pharmaceutical plant Hypericum adenotrichum Spach endemic to Western Turkey

Ali Özmen, Sabine Bauer, Manuela Gridling, Judith Singhuber, Stanimira Krasteva, Sibylle Madlener, Than Phuong Nha Vo, Nicole Stark, Philipp Saiko, Monika Fritzer-Szekeres, Thomas Szekeres, Tülay Askin-Celik, Liselotte Krenn, Georg Krupitza
Pages: 845-852
Published online on: 01 October 2009

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Article

Identification of candidate epigenetic biomarkers for ovarian cancer detection

Yi-Wen Huang, Rachel A. Jansen, Enrica Fabbri, Dustin Potter, Sandya Liyanarachchi, Michael W.Y. Chan, Joseph C. Liu, Anne P.G. Crijns, Robert Brown, Kenneth P. Nephew, Ate G.J. van der Zee, David E. Cohn, Pearlly S. Yan, Tim H.-M. Huang, Huey-Jen L. Lin
Pages: 853-861
Published online on: 01 October 2009

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Article

Identification of specific microRNAs responding to low and high dose γ-irradiation in the human lymphoblast line IM9

Hwa Jun Cha, Ki Moon Seong, Seunghee Bae, Jin Hyuk Jung, Cha Soon Kim, Kwang-Hee Yang, Young-Woo Jin, Sungkwan An
Pages: 863-868
Published online on: 01 October 2009

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Article

Increased sensitivity to platinating agents and arsenite in human ovarian cancer by downregulation of ASNA1

Oskar Hemmingsson, Mikael Nöjd, Gautam Kao, Peter Naredi
Pages: 869-875
Published online on: 01 October 2009

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Article

A pilot study of Auron Misheil Therapy in patients with advanced cervical cancer: Tumor response and its correlation with clinical benefit response, and preliminary quality of life data

Jürgen Scheele, Faiz Niazi, Joachim Drevs, Klaus Diergarten, Papa Toure
Pages: 877-883
Published online on: 01 October 2009

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Article

Long-term results of radiofrequency ablation in colorectal lung metastases: Single center experience

Koichiro Yamakado, Yasuhiro Inoue, Motoshi Takao, Haruyuki Takaki, Atsuhiro Nakatsuka, Junji Uraki, Masataka Kashima, Masato Kusunoki, Hideto Shimpo, Kan Takeda
Pages: 885-891
Published online on: 01 October 2009

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Article

Efficacy of hybrid 2-port hand-assisted laparoscopic surgery (Mukai's operation) for patients with primary colorectal cancer

Masaya Mukai, Kyoko Kishima, Takayuki Tajima, Tatsuhiko Hoshikawa, Naoki Yazawa, Hiroshi Fukumitsu, Kazutake Okada, Kyouji Ogoshi, Hiroyasu Makuuchi
Pages: 893-899
Published online on: 01 October 2009

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Article

Microdissection is essential for gene expression analysis of irradiated rectal cancer tissues

Yasuhiro Inoue, Koji Tanaka, Takeshi Yokoe, Susumu Saigusa, Yuji Toiyama, Chikao Miki, Masato Kusunoki
Pages: 901-906
Published online on: 01 October 2009

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Article

Underexpression of PPARγ is associated with aneuploidy and lower differentiation of thyroid tumours of follicular origin

Carla Espadinha, António E. Pinto, Valeriano Leite
Pages: 907-913
Published online on: 01 October 2009

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Article

The antitumor immune responses induced by nanoemulsion-encapsulated MAGE1-HSP70/SEA complex protein vaccine following different administration routes

Wei Ge, Pei-Zhen Hu, Yang Huang, Xiao-Ming Wang, Xiu-Min Zhang, Yu-Jing Sun, Zeng-Shan Li, Shao-Yan Si, Yan-Fang Sui
Pages: 915-920
Published online on: 01 October 2009

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Article

Facilitation of drug resistance development by γ-irradiation in human cancer cells

Tsun Yee Tsang, Sze Wing Tsang, Ka Po Lai, Wing Pui Tsang, Ngai Na Co, Tim Tak Kwok
Pages: 921-926
Published online on: 01 October 2009

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Article

Clues pointing to simple hysterectomy to treat early-stage cervical cancer

Charles Coutant, Anne Gaël Cordier, Eric Guillo, Marcos Ballester, Roman Rouzier, Emile Daraï
Pages: 927-934
Published online on: 01 October 2009

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Article Open Access

Toll-like receptor 9 agonist inhibits ERα-mediated transactivation by activating NF-κB in breast cancer cell lines

Jianming Qiu, Xiaojian Wang, Xinhai Guo, Chenyin Zhao, Xuhui Wu, Yongkui Zhang
Pages: 935-941
Published online on: 01 October 2009

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Article

American ginseng berry enhances chemopreventive effect of 5-FU on human colorectal cancer cells

Xiao-Li Li, Chong-Zhi Wang, Shi Sun, Sangeeta R. Mehendale, Wei Du, Tong-Chuan He, Chun-Su Yuan
Pages: 943-952
Published online on: 01 October 2009

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Article

Human HSP70 and modified HPV16 E7 fusion DNA vaccine induces enhanced specific CD8+ T cell responses and anti-tumor effects

Jinbao Zong, Qinglin Peng, Qingyong Wang, Ting Zhang, Dongsheng Fan, Xuemei Xu
Pages: 953-961
Published online on: 01 October 2009

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Journal Cover
May-2026 Volume 55 Issue 5

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Article Open Access

ZBTB7A promotes malignant phenotypes in ovarian cancer through transcriptional activation of CRLF1

Xiaobai Hao, Yu Chen
Article Number: 102
Published online on: 24 March 2026

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Article Open Access

MS4322 is a selective protein arginine methyltransferase 5 degrader with antitumor effects in cervical cancer cells

Rui Luo, Jingping Chen, Zhaojie Chen, Surong Wang, Tianfeng Liu, Yang Xu
Article Number: 101
Published online on: 24 March 2026

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Retraction Open Access

[Retracted] Roles of the SNHG7/microRNA‑9‑5p/DPP4 ceRNA network in the growth and 131I resistance of thyroid carcinoma cells through PI3K/Akt activation

Wanzhi Chen, Jichun Yu, Rong Xie, Tao Zhou, Chengfeng Xiong, Shuyong Zhang, Meijun Zhong
Article Number: 100
Published online on: 23 March 2026

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Article Open Access

Andrographis exerts antitumor effects and enhances 5‑FU efficacy via the alteration of ferroptosis‑related genes in esophageal squamous cell carcinoma

Kosuke Yoshimura, Tadanobu Shimura, Ruiya Ma, Yaxuan Huang, Takahito Kitajima, Shinji Yamashita, Yuki Sato, Koki Higashi, Mikio Kawamura, Hiromi Yasuda, Yuhki Koike, Yoshiki Okita, Shigeyuki Yoshiyama, Minako Kobayashi, Masaki Ohi, Hiroki Ohge, Shinya Takahashi, Ajay Goel, Yoshinaga Okugawa, Yuji Toiyama
Article Number: 99
Published online on: 20 March 2026

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Article Open Access

Sphingosine‑1‑phosphate receptor 1 enhances olfactory receptor 51E1‑mediated inhibition of proliferation via Src/JNK signaling in prostate cancer cells

Kiheon Kim, Jinwoo Lee, Chulwon Choi, Jungnam Bae, Hee-Jung Choi, Won-Ki Huh
Article Number: 98
Published online on: 19 March 2026

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Review Open Access

Mechanistic insights into the roles of astragalosides and Astragalus polysaccharides in gynecological and breast cancers (Review)

Ruixin Liu, Zhanyu Lin, Yuelin Li, Yuetong Ci, Zhengqi Guo, Zhenguo Xu
Article Number: 97
Published online on: 19 March 2026

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Retraction Open Access

[Retracted] Inhibition of tankyrase 1 in human gastric cancer cells enhances telomere shortening by telomerase inhibitors 

Hao Zhang, Meng-Hua Yang, Jing-Jing Zhao, Ling Chen, Song-Tao Yu, Xu-Dong Tang, Dian-Chun Fang, Shi-Ming Yang
Article Number: 96
Published online on: 16 March 2026

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Article Open Access

Silencing of SIVA‑1 promotes cisplatin resistance in gastric cancer via the Bcl‑2/BAX‑mediated mitochondria‑dependent apoptosis pathway

Zheng-Yi Shi, Zheng-Rong Ding, Yu-Liang Huang, Yuan-Rui Lei, Hai-Bin Huang, Yan Qing, Miao-Ren Deng, Xu-Man Lu, Xu-Dong Dong, Long-Jie Xia, Sheng Xu, Xiao-Gang Zhong, Lei Li, Fan-Biao Kong, Xiao-Tong Wang
Article Number: 95
Published online on: 13 March 2026

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Article Open Access

Depleting HIF‑1α attenuates the progression of osteosarcoma, but tumorigenicity is sustained through HIF‑independent pathways

Ayaka Kunishima, Takatsune Shimizu, Tetsuya Takimoto, Atsunobu Sagara, Hiroyuki Nobusue, Hidetoshi Hasuwa, Shinya Hasegawa, Yuka Tamaoki, Hitomi Miyake, Yumi Fukuchi, Hideyuki Saya, Akihiro Muto
Article Number: 94
Published online on: 12 March 2026

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Article Open Access

Unveiling the role of ANGPT2 in esophageal cancer: A prognostic factor and potential oncogene

Zhigang Zhai, Zhenyu Xue, Yuan Fang, Yixu Fan, Shijiao Li, Yunpeng Yu, Chuansheng Chen, Kaijun Zhang, Deyu Chen, Xiang Tang, Rui Ling
Article Number: 93
Published online on: 12 March 2026

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Article Open Access

POLQ promotes tumor progression and immunosuppression via ATM‑P53 signaling in endometrial cancer

Ningning Zhu, Juanjuan Wang, Xiaoli Zhang, Kai Tang, Lei Gong, Yi Hu
Article Number: 92
Published online on: 11 March 2026

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Correction Open Access

[Corrigendum] 3‑Bromopyruvate and sodium citrate target glycolysis, suppress survivin, and induce mitochondrial‑mediated apoptosis in gastric cancer cells and inhibit gastric orthotopic transplantation tumor growth

Ting-An Wang, Xiao-Dong Zhang, Xing-Yu Guo, Shu-Lin Xian, Yun-Fei Lu
Article Number: 91
Published online on: 11 March 2026

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Review Open Access

Unveiling the molecular landscape: Long non-coding RNAs in neuroblastoma (Review)

Zidong Xia, Huishan Zhai, Lei Zheng, Cheng Wang
Article Number: 90
Published online on: 09 March 2026

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Retraction Open Access

[Retracted] Erastin sensitizes glioblastoma cells to temozolomide by restraining xCT and cystathionine‑γ‑lyase function

Liangyu Chen, Xinxing Li, Libo Liu, Bo Yu, Yixue Xue, Yunhui Liu
Article Number: 89
Published online on: 09 March 2026

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Review Open Access

Advances in the application of frailty scoring in the diagnosis and management of elderly patients with multiple myeloma (Review)

Junlun Liu, Danyu Li, Chao Li, Zhuoren Chen
Article Number: 88
Published online on: 06 March 2026

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Expression of Concern Open Access

[Expression of Concern] c‑Fos/ERK promotes the progression from pancreatic intraepithelial neoplasia to pancreatic ductal adenocarcinoma 

Lei You, Xiaoxia Ren, Yongxing Du, Wenjing Zhao, Ming Cui, Ge Chen, Yupei Zhao
Article Number: 87
Published online on: 05 March 2026

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Review Open Access

CXCL1 in triple‑negative breast cancer: Mechanisms, challenges, and therapeutic opportunities (Review)

Hiba Al Sayegh, Zahraa Assi, Amjad Kanaan, Mirvat El Sibai
Article Number: 86
Published online on: 03 March 2026

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Article Open Access

Cellular and inflammatory characteristics of patient‑derived glioblastoma organoids during in vitro cultivation

Jessica Nojszewski, Nils Oliver Schröder, Jacqueline Clüver, Jonna Holler, Hajrullah Ahmeti, Michael Synowitz, Janka Held-Feindt
Article Number: 85
Published online on: 02 March 2026

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Retraction Open Access

[Retracted] Growth and differentiation factor‑9 promotes adhesive and motile capacity of prostate cancer cells by up‑regulating FAK and Paxillin via Smad dependent pathway 

Sivan M. Bokobza, Lin Ye, Howard G. Kynaston, Wen G. Jiang
Article Number: 84
Published online on: 02 March 2026

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Article Open Access

Platycodin D sensitizes head and neck squamous cell carcinoma to cisplatin by inducing autophagy arrest

Minji Bae, Min Kyeong Lee, Mi Gyeong Jeong, Yeonseo Lee, Harim Joo, Young Chan Lee, Jung Woo Lee, Su Il Kim, Seong-Gyu Ko, Young-Gyu Eun
Article Number: 83
Published online on: 27 February 2026

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Article Open Access

ACSBG1‑driven lipid reprogramming unveiled: A fatty acid metabolism‑associated prognostic model for lung adenocarcinoma

Panxin Hu, Anan Li
Article Number: 82
Published online on: 27 February 2026

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Article Open Access

Knockdown of CCT2 inhibits the malignant progression of hepatocellular carcinoma cells by impairing STAT3 activation

Chao Li, Lei Yang, Yudong Zhang, Baocheng Zhao, Hao Qu
Article Number: 81
Published online on: 25 February 2026

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Retraction Open Access

[Retracted] Songorine suppresses cell growth and metastasis in epithelial ovarian cancer via the Bcl‑2/Bax and GSK3β/β‑catenin signaling pathways

Hongxia Zhang, Ruifeng Dong, Ping Zhang, Yankui Wang
Article Number: 80
Published online on: 25 February 2026

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June-2026 Volume 55 Issue 6

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Expression of Concern Open Access

[Expression of Concern] 5‑Azacytidine inhibits the proliferation of bladder cancer cells via reversal of the aberrant hypermethylation of the hepaCAM gene

Xiaorong Wang, E. Chen, Xue Yang, Yin Wang, Zhen Quan, Xiaohou Wu, Chunli Luo
Article Number: 103
Published online on: 30 March 2026

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