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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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October 2009 Volume 22 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

CD44v6, MMP-7 and nuclear Cdx2 are significant biomarkers for prediction of lymph node metastasis in primary gastric cancer

  • Authors:
    • Hirokazu Okayama
    • Kensuke Kumamoto
    • Katsuharu Saitou
    • Suguru Hayase
    • Yasuhide Kofunato
    • Yu Sato
    • Kotaro Miyamoto
    • Izumi Nakamura
    • Shinji Ohki
    • Kouji Sekikawa
    • Seiichi Takenoshita

  • View Affiliations / Copyright

    Affiliations: Department of Organ Regulatory Surgery, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan
  • Pages: 745-755
    |
    Published online on: October 1, 2009
       https://doi.org/10.3892/or_00000496
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Abstract

The aim of this study was to examine the expression of CD44v6, CD54, Cdx2, CXCL5, Cyclin B1, MMP-7, nm23, RCAS1 and Survivin in primary gastric cancer and to investigate whether these molecules were useful in predicting the lymph node status. They were selected as candidates for indicators of lymph node metastasis from various kinds of cancer-associated genes reported previously. In 135 cases of radically resected primary gastric adenocarcinoma, we investigated the association between the expression of these molecules and clinocopathologic factors by immunohistochemistry. The results revealed that the expression of CD44v6 and MMP-7 were significantly associated with lymph node status. By contrast, nuclear Cdx2 expression was found to be inversely correlated with lymph node metastasis. Moreover, multivariate analysis demonstrated that CD44v6, MMP-7 and nuclear Cdx2 were independent predictors for lymph node status. In conclusion, our results suggest that positive expression of both CD44v6 and MMP-7, and negative expression of nuclear Cdx2 may serve as powerful predictors of lymph node metastasis in gastric cancer. Combined evaluation of these markers could be further useful to predict lymph node status clinically.

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Copy and paste a formatted citation
Spandidos Publications style
Okayama H, Kumamoto K, Saitou K, Hayase S, Kofunato Y, Sato Y, Miyamoto K, Nakamura I, Ohki S, Sekikawa K, Sekikawa K, et al: CD44v6, MMP-7 and nuclear Cdx2 are significant biomarkers for prediction of lymph node metastasis in primary gastric cancer. Oncol Rep 22: 745-755, 2009.
APA
Okayama, H., Kumamoto, K., Saitou, K., Hayase, S., Kofunato, Y., Sato, Y. ... Takenoshita, S. (2009). CD44v6, MMP-7 and nuclear Cdx2 are significant biomarkers for prediction of lymph node metastasis in primary gastric cancer. Oncology Reports, 22, 745-755. https://doi.org/10.3892/or_00000496
MLA
Okayama, H., Kumamoto, K., Saitou, K., Hayase, S., Kofunato, Y., Sato, Y., Miyamoto, K., Nakamura, I., Ohki, S., Sekikawa, K., Takenoshita, S."CD44v6, MMP-7 and nuclear Cdx2 are significant biomarkers for prediction of lymph node metastasis in primary gastric cancer". Oncology Reports 22.4 (2009): 745-755.
Chicago
Okayama, H., Kumamoto, K., Saitou, K., Hayase, S., Kofunato, Y., Sato, Y., Miyamoto, K., Nakamura, I., Ohki, S., Sekikawa, K., Takenoshita, S."CD44v6, MMP-7 and nuclear Cdx2 are significant biomarkers for prediction of lymph node metastasis in primary gastric cancer". Oncology Reports 22, no. 4 (2009): 745-755. https://doi.org/10.3892/or_00000496
Copy and paste a formatted citation
x
Spandidos Publications style
Okayama H, Kumamoto K, Saitou K, Hayase S, Kofunato Y, Sato Y, Miyamoto K, Nakamura I, Ohki S, Sekikawa K, Sekikawa K, et al: CD44v6, MMP-7 and nuclear Cdx2 are significant biomarkers for prediction of lymph node metastasis in primary gastric cancer. Oncol Rep 22: 745-755, 2009.
APA
Okayama, H., Kumamoto, K., Saitou, K., Hayase, S., Kofunato, Y., Sato, Y. ... Takenoshita, S. (2009). CD44v6, MMP-7 and nuclear Cdx2 are significant biomarkers for prediction of lymph node metastasis in primary gastric cancer. Oncology Reports, 22, 745-755. https://doi.org/10.3892/or_00000496
MLA
Okayama, H., Kumamoto, K., Saitou, K., Hayase, S., Kofunato, Y., Sato, Y., Miyamoto, K., Nakamura, I., Ohki, S., Sekikawa, K., Takenoshita, S."CD44v6, MMP-7 and nuclear Cdx2 are significant biomarkers for prediction of lymph node metastasis in primary gastric cancer". Oncology Reports 22.4 (2009): 745-755.
Chicago
Okayama, H., Kumamoto, K., Saitou, K., Hayase, S., Kofunato, Y., Sato, Y., Miyamoto, K., Nakamura, I., Ohki, S., Sekikawa, K., Takenoshita, S."CD44v6, MMP-7 and nuclear Cdx2 are significant biomarkers for prediction of lymph node metastasis in primary gastric cancer". Oncology Reports 22, no. 4 (2009): 745-755. https://doi.org/10.3892/or_00000496
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