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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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November 2009 Volume 22 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

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Article

Houttuynia cordata Thunb extract induces apoptosis through mitochondrial-dependent pathway in HT-29 human colon adenocarcinoma cells

  • Authors:
    • Yih-Jing Tang
    • Jai-Sing Yang
    • Chin-Fen Lin
    • Woei-Cherng Shyu
    • Minoru Tsuzuki
    • Chi-Cheng Lu
    • Yuh-Fung Chen
    • Kuang-Chi Lai

  • View Affiliations / Copyright

    Affiliations: Department of Family Medicine, Taichung Veterans General Hospital, Taichung, Taiwan, R.O.C.
  • Pages: 1051-1056
    |
    Published online on: November 1, 2009
       https://doi.org/10.3892/or_00000535
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Abstract

The Houttuynia cordata Thunb (HCT) extract has been used as a traditional Chinese herb medicine and as well as an effective drug for treating allergic inflammation for thousands of years. In this study, we investigated the anti-cancer activity of HCT and its molecular mechanisms in the human colon adenocarcinoma cell line HT-29. HCT inhibited HT-29 cell viability in a dose- and time-dependent manner by MTT assay. Treatment with 450 µg/ml of HCT for 48 and 72 h led to DNA damage and apoptosis by DAPI staining and comet assay. HCT increased reactive oxygen species production and decreased the levels of mitochondria membrane potential (MMP) in HT-29 cells by flow cytometry analysis. HCT caused the release of cytochrome c, Apaf-1, pro-caspase-9 and AIF from mitochondria via a decrease of the MMP. The decrease of MMP was then associated with a decrease in the ratio of Bax/Bcl-2 and activation of caspase-9 and -3 by Western blotting and caspase activity assay. Caspase-9 and -3 inhibitors almost completely suppressed HCT-induced caspase-9 and -3 activities. Our results demonstrated that the HCT-induced apoptosis in human colon adenocarcinoma cell line HT-29 might be related to a mitochondrial-dependent pathway.

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Copy and paste a formatted citation
Spandidos Publications style
Tang Y, Yang J, Lin C, Shyu W, Tsuzuki M, Lu C, Chen Y and Lai K: Houttuynia cordata Thunb extract induces apoptosis through mitochondrial-dependent pathway in HT-29 human colon adenocarcinoma cells. Oncol Rep 22: 1051-1056, 2009.
APA
Tang, Y., Yang, J., Lin, C., Shyu, W., Tsuzuki, M., Lu, C. ... Lai, K. (2009). Houttuynia cordata Thunb extract induces apoptosis through mitochondrial-dependent pathway in HT-29 human colon adenocarcinoma cells. Oncology Reports, 22, 1051-1056. https://doi.org/10.3892/or_00000535
MLA
Tang, Y., Yang, J., Lin, C., Shyu, W., Tsuzuki, M., Lu, C., Chen, Y., Lai, K."Houttuynia cordata Thunb extract induces apoptosis through mitochondrial-dependent pathway in HT-29 human colon adenocarcinoma cells". Oncology Reports 22.5 (2009): 1051-1056.
Chicago
Tang, Y., Yang, J., Lin, C., Shyu, W., Tsuzuki, M., Lu, C., Chen, Y., Lai, K."Houttuynia cordata Thunb extract induces apoptosis through mitochondrial-dependent pathway in HT-29 human colon adenocarcinoma cells". Oncology Reports 22, no. 5 (2009): 1051-1056. https://doi.org/10.3892/or_00000535
Copy and paste a formatted citation
x
Spandidos Publications style
Tang Y, Yang J, Lin C, Shyu W, Tsuzuki M, Lu C, Chen Y and Lai K: Houttuynia cordata Thunb extract induces apoptosis through mitochondrial-dependent pathway in HT-29 human colon adenocarcinoma cells. Oncol Rep 22: 1051-1056, 2009.
APA
Tang, Y., Yang, J., Lin, C., Shyu, W., Tsuzuki, M., Lu, C. ... Lai, K. (2009). Houttuynia cordata Thunb extract induces apoptosis through mitochondrial-dependent pathway in HT-29 human colon adenocarcinoma cells. Oncology Reports, 22, 1051-1056. https://doi.org/10.3892/or_00000535
MLA
Tang, Y., Yang, J., Lin, C., Shyu, W., Tsuzuki, M., Lu, C., Chen, Y., Lai, K."Houttuynia cordata Thunb extract induces apoptosis through mitochondrial-dependent pathway in HT-29 human colon adenocarcinoma cells". Oncology Reports 22.5 (2009): 1051-1056.
Chicago
Tang, Y., Yang, J., Lin, C., Shyu, W., Tsuzuki, M., Lu, C., Chen, Y., Lai, K."Houttuynia cordata Thunb extract induces apoptosis through mitochondrial-dependent pathway in HT-29 human colon adenocarcinoma cells". Oncology Reports 22, no. 5 (2009): 1051-1056. https://doi.org/10.3892/or_00000535
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