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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
November 2009 Volume 22 Issue 5

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Journal Metrics

Impact Factor: 4.7

CiteScore: 7.7

CiteScore Rank: Q1: #76/428 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review

Epigenetic DNA hypermethylation: Clinical applications in endometrial cancer (Review)

Yuriko Muraki, Kouji Banno, Megumi Yanokura, Yusuke Kobayashi, Makiko Kawaguchi, Hiroyuki Nomura, Akira Hirasawa, Nobuyuki Susumu, Daisuke Aoki
Pages: 967-972
Published online on: 01 November 2009

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Review

Focal adhesion kinase as potential target for cancer therapy (Review)

Huifang Hao, Yoshio Naomoto, Xiaohong Bao, Nobuyuki Watanabe, Kazufumi Sakurama, Kazuhiro Noma, Takayuki Motoki, Yasuko Tomono, Takuya Fukazawa, Yasuhiro Shirakawa, Tomoki Yamatsuji, Junji Matsuoka, Z. G. Wang, Munenori Takaoka
Pages: 973-979
Published online on: 01 November 2009

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Review

Human gonadotropin-releasing hormone receptor-activated cellular functions and signaling pathways in extra-pituitary tissues and cancer cells (Review)

Arturo Aguilar-Rojas, Maira Huerta-Reyes
Pages: 981-990
Published online on: 01 November 2009

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Article

Myosin VI is a modulator of androgen-dependent gene expression

Ildikó Loikkanen, Katja Toljamo, Pasi Hirvikoski, Timo Väisänen, Timo K. Paavonen, Markku H. Vaarala
Pages: 991-995
Published online on: 01 November 2009

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Article

Three-dimensional alginate spheroid culture system of murine osteosarcoma

Koji Akeda, Akinobu Nishimura, Haruhiko Satonaka, Ken Shintani, Katsuyuki Kusuzaki, Akihiko Matsumine, Yuichi Kasai, Koichi Masuda, Atsumasa Uchida
Pages: 997-1003
Published online on: 01 November 2009

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Article

Expression of the FAM5C in tongue squamous cell carcinoma

Tsukasa Kuroiwa, Nobuharu Yamamoto, Takeshi Onda, Takahiko Shibahara
Pages: 1005-1011
Published online on: 01 November 2009

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Article

The status of KRAS mutations in patients with non-small cell lung cancers from mainland China

Mei Li, Lina Liu, Zhimin Liu, Shichang Yue, Luming Zhou, Qiuping Zhang, Shihua Cheng, Rachel W. Li, Paul N. Smith, Shen Lu
Pages: 1013-1020
Published online on: 01 November 2009

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Article

Vitamin D receptor expression is associated with colon cancer in ulcerative colitis

Koji Wada, Hiroaki Tanaka, Kiyoshi Maeda, Toru Inoue, Eiji Noda, Ryosuke Amano, Naoshi Kubo, Kazuya Muguruma, Nobuya Yamada, Masakazu Yashiro, Tetsuji Sawada, Bunzo Nakata, Masaichi Ohira, Kosei Hirakawa
Pages: 1021-1025
Published online on: 01 November 2009

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Article

High expression of N-acetylglucosaminyltransferase V in mucinous tumors of the ovary

Noriko Takahashi, Eiko Yamamoto, Kazuhiko Ino, Eiji Miyoshi, Tetsuro Nagasaka, Hiroaki Kajiyama, Kiyosumi Shibata, Akihiro Nawa, Fumitaka Kikkawa
Pages: 1027-1032
Published online on: 01 November 2009

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Article

Danthron inhibits the migration and invasion of human brain glioblastoma multiforme cells through the inhibition of mRNA expression of focal adhesion kinase, Rho kinases-1 and metalloproteinase-9

Chin-Chung Lin, Jin-Tang Chen, Jai-Sing Yang, Hsu-Feng Lu, Shu-Chun Hsu, Tzu-Wei Tan, Yuh-Tzy Lin, Yi-Shih Ma, Siu-Wan Ip, Jia-Jiuan Wu, Yu-Chinh Li, Jing-Gung Chung
Pages: 1033-1037
Published online on: 01 November 2009

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Article

Use of telomelysin (OBP-301) in mouse xenografts of human head and neck cancer

Oumi Nakajima, Daiju Ichimaru, Yasuo Urata, Toshiyoshi Fujiwara, Tomohisa Horibe, Masayuki Kohno, Koji Kawakami
Pages: 1039-1043
Published online on: 01 November 2009

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Article

Hyperbaric oxygen as a chemotherapy adjuvant in the treatment of osteosarcoma

Yasuomi Kawasoe, Masahiro Yokouchi, Yoshinori Ueno, Hiroaki Iwaya, Hiroki Yoshida, Setsuro Komiya
Pages: 1045-1050
Published online on: 01 November 2009

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Article

Houttuynia cordata Thunb extract induces apoptosis through mitochondrial-dependent pathway in HT-29 human colon adenocarcinoma cells

Yih-Jing Tang, Jai-Sing Yang, Chin-Fen Lin, Woei-Cherng Shyu, Minoru Tsuzuki, Chi-Cheng Lu, Yuh-Fung Chen, Kuang-Chi Lai
Pages: 1051-1056
Published online on: 01 November 2009

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Article

Different expression of mimecan as a marker for differential diagnosis between NSCLC and SCLC

Cui-Xia Zheng, Shuang-Xia Zhao, Ping Wang, Hui-Min Yu, Cao-Fu Wang, Bing Han, Bin Su, Yi Xiang, Xue-Song Li, Sheng-Xian Li, Qin-Yun Ma, Rong-Xin Zhang, Huan-Ying Wan, Huai-Dong Song
Pages: 1057-1061
Published online on: 01 November 2009

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Article

Estrogen receptor-β expression in human laryngeal carcinoma: correlation with the expression of epithelial-mesenchymal transition specific biomarkers

Anastasios K. Goulioumis, Jonas Fuxe, John Varakis, Maria Repanti, Panos Goumas, Helen Papadaki
Pages: 1063-1068
Published online on: 01 November 2009

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Article

Induction of tumor inhibition and apoptosis by a candidate tumor suppressor gene DRR1 on 3p21.1

Quan Liu, Xin-Yu Zhao, Rui-Zhen Bai, Shu-Fang Liang, Chun-Lai Nie, Zhu Yuan, Chun-Ting Wang, Yang Wu, Li-Juan Chen, Yu-Quan Wei
Pages: 1069-1075
Published online on: 01 November 2009

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Article

A traditional Chinese medicine formulation consisting of Rhizoma Corydalis and Rhizoma Curcumae exerts synergistic anti-tumor activity

Jian-Li Gao, Tong-Chuan He, Ying-Bo Li, Yi-Tao Wang
Pages: 1077-1083
Published online on: 01 November 2009

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Article

Efficient preparation of highly pure chlorin e6 and its photodynamic anti-cancer activity in a rat tumor model

Yeon-Hee Moon, Seong-Min Kwon, Hyo-Jun Kim, Kwan-Young Jung, Jong-Hwan Park, Soo-A Kim, Yong-Chul Kim, Sang-Gun Ahn, Jung-Hoon Yoon
Pages: 1085-1091
Published online on: 01 November 2009

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Article

Endothelial VEGFR-3 expression in colorectal carcinomas is associated with hematogenous metastasis

C. Jayasinghe, N. Simiantonaki, R. Michel-Schmidt, C. J. Kirkpatrick
Pages: 1093-1100
Published online on: 01 November 2009

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Article

Hepatitis B virus X protein (HBx) induces G2/M arrest and apoptosis through sustained activation of cyclin B1-CDK1 kinase

Ping Cheng, Yuhua Li, Liping Yang, Yanjun Wen, Wei Shi, Yongqiu Mao, Ping Chen, Huimin Lv, Qingqing Tang, Yuquan Wei
Pages: 1101-1107
Published online on: 01 November 2009

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Article

Expression and prognostic value of L1-CAM in breast cancer

Christine Schröder, Udo Schumacher, Mina Fogel, Friedrich Feuerhake, Volkmar Müller, Ralph M. Wirtz, Peter Altevogt, Sylke Krenkel, Fritz Jänicke, Karin Milde-Langosch
Pages: 1109-1117
Published online on: 01 November 2009

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Article

MMP13 is potentially a new tumor marker for breast cancer diagnosis

Hui-Jen Chang, Ming-Je Yang, Yu-Hsiang Yang, Ming-Feng Hou, Er-Jung Hsueh, Shiu-Ru Lin
Pages: 1119-1127
Published online on: 01 November 2009

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Article

Identification and characterization of cancer stem-like cells from primary carcinoma of the cervix uteri

Dingqing Feng, Cheng Peng, Cairong Li, Ying Zhou, Min Li, Bin Ling, Haiming Wei, Zhigang Tian
Pages: 1129-1134
Published online on: 01 November 2009

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Article

CD44 expression during tumor progression of follicular lymphoma

Morihiro Higashi, Yoshiki Sugaya, Satoshi Soeta, Akira Yokota, Genichiro Ishii, Kenichi Harigaya
Pages: 1135-1140
Published online on: 01 November 2009

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Article

Analysis of the expression profiles of cytokines and cytokine-related genes during the progression of breast cancer growth in mice

Mi Young Jung, Seung Hyun Kim, Daeho Cho, Tae Sung Kim
Pages: 1141-1147
Published online on: 01 November 2009

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Article

CD24 overexpression in cancer development and progression: A meta-analysis

Ju-Han Lee, Seo-Hee Kim, Eung-Seok Lee, Young-Sik Kim
Pages: 1149-1156
Published online on: 01 November 2009

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Article

Induction chemoradiotherapy followed by surgery for locally advanced non-small cell lung cancer

Sojiro Kusumoto, Takashi Hirose, Motoko Fukayama, Daisuke Kataoka, Kenji Hamada, Tomohide Sugiyama, Takao Shirai, Toshimitsu Yamaoka, Kentaro Okuda, Tsukasa Ohnishi, Tohru Ohmori, Mitsutaka Kadokura, Mitsuru Adachi
Pages: 1157-1162
Published online on: 01 November 2009

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Article

Concurrent chemoradiotherapy for organ function preservation in advanced patients with hypopharyngeal and laryngeal cancer

Yasunao Kogashiwa, Kohichi Yamauchi, Hiroshi Nagafuji, Takehiro Matsuda, Toshihito Tsubosaka, Tomoko Tsutsumi, Takehiro Karaho, Naoyuki Kohno
Pages: 1163-1167
Published online on: 01 November 2009

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Article

Tumor necrosis factor-related apoptosis-inducing ligand induces apoptotic cell death through c-Jun NH2-terminal kinase activation in squamous cell carcinoma cells

Takenori Noutomi, Mizue Itoh, Hiroko Toyota, Eiko Takada, Junichiro Mizuguchi
Pages: 1169-1172
Published online on: 01 November 2009

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Article

Aberrant promoter hypermethylation of the CHFR gene in oral squamous cell carcinomas

Seiji Baba, Akira Hara, Keizo Kato, Nguyen Khanh Long, Yuichiro Hatano, Masashi Kimura, Yukio Okano, Yasuhiro Yamada, Toshiyuki Shibata
Pages: 1173-1179
Published online on: 01 November 2009

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Article

FOXP3 expression of micrometastasis-positive sentinel nodes in breast cancer patients

Kazuo Matsuura, Yoshiyuki Yamaguchi, Akihiko Osaki, Masahiro Ohara, Riki Okita, Akiko Emi, Shigeru Murakami, Koji Arihiro
Pages: 1181-1187
Published online on: 01 November 2009

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Article

Let-7a microRNA functions as a potential tumor suppressor in human laryngeal cancer

Xiao-Bo Long, Guang-Bin Sun, Shuang Hu, Geng-Tian Liang, Nan Wang, Xin-Hao Zhang, Ping-Ping Cao, Hong-Tao Zhen, Yong-Hua Cui, Zheng Liu
Pages: 1189-1195
Published online on: 01 November 2009

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Article

Enhancement of DNA cancer vaccine efficacy by combination with anti-angiogenesis in regression of established subcutaneous B16 melanoma

Ray Chun-Fai Chan, Benjamin Gutierrez, Thomas E. Ichim, Feng Lin
Pages: 1197-1203
Published online on: 01 November 2009

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Article

Intronic polymorphisms in TP53 indicate lymph node metastasis in breast cancer

Roman Hrstka, Michal Beranek, Katerina Klocova, Rudolf Nenutil, Borivoj Vojtesek
Pages: 1205-1211
Published online on: 01 November 2009

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Article

Co-expression of P1A35-43/β2m fusion protein and co-stimulatory molecule CD80 elicits effective anti-tumor immunity in the P815 mouse mastocytoma tumor model

Xingqian Zhang, Wenhan Mei, Leilei Zhang, Hai Yu, Xiaoping Zhao, Xianqun Fan, Guanxiang Qian, Shengfang Ge
Pages: 1213-1220
Published online on: 01 November 2009

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Article

Promoter histone H3 lysine 9 di-methylation is associated with DNA methylation and aberrant expression of p16 in gastric cancer cells

Chun-Feng Meng, Xin-Jiang Zhu, Guo Peng, Dong-Qiu Dai
Pages: 1221-1227
Published online on: 01 November 2009

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Article

A role of functional T-type Ca2+ channel in hepatocellular carcinoma cell proliferation

Yajuan Li, Shuang Liu, Fengmin Lu, Ting Zhang, Hairu Chen, Songwei Wu, Hui Zhuang
Pages: 1229-1235
Published online on: 01 November 2009

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Article

Cisplatin cytotoxicity is increased by mifepristone in cervical carcinoma: An in vitro and in vivo study

Rafael Jurado, Angelica Lopez-Flores, Aaron Alvarez, Patricia García-López
Pages: 1237-1245
Published online on: 01 November 2009

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Article

Depletion of the proteasome subunit PSMA7 inhibits colorectal cancer cell tumorigenicity and migration

Xiao-Tong Hu, Wei Chen, Fu-Biao Zhang, Qing-Lan Shi, Jian-Bin Hu, Shu-Min Geng, Chao He
Pages: 1247-1252
Published online on: 01 November 2009

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Article

The characterization of blood flow changes in mouse tumor during Photofrin-based photodynamic therapy by using the color Doppler ultrasonography

Karmen Dubreta, Sinisa Ivankovic, Arijana Lovrencic-Huzjan, Marijana Bosnar-Puretic, Ranko Stojkovic, Mislav Jurin
Pages: 1253-1257
Published online on: 01 November 2009

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Journal Cover
September-2026 Volume 56 Issue 3

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Journal Metrics

Impact Factor: 4.7

CiteScore: 7.7

CiteScore Rank: Q1: #76/428 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Article Open Access

Polyphyllin II inhibits thyroid cancer progression by targeting HRH1 and suppressing Wnt/β‑catenin signaling

Jianwei Sun, Haifeng Liang, Yan Zhang, Ding Ding, Qian Xiang, Mengyang Zheng, Pengyue Zhang
Article Number: 163
Published online on: 23 July 2026

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Review Open Access

Multidimensional molecular mechanisms of drug resistance in breast cancer: Implications for clinical decision‑making and treatment strategies (Review)

Wenya Xu, Shiyao Kang, Shaochen Xin, Yanbin Wu, Yuan Zhao, Miaomiao Sheng
Article Number: 162
Published online on: 22 July 2026

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Review Open Access

XPO1: From basic research to clinical treatment (Review)

Changyan Yang, Jing Zhu, Xiang Zheng, Xiaochen Hou, Jiumei Zhao, Youfu Pan, Yu Tang
Article Number: 161
Published online on: 22 July 2026

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Retraction Open Access

[Retracted] Methylation and intratumoural heterogeneity of 14‑3‑3 σ in oral cancer

Ujjal Kumar Bhawal, Keiichi Tsukinoki, Tomonori Sasahira, Fuyuki Sato, Yusuke Mori, Noriko Muto, Masaru Sugiyama, Hiroki Kuniyasu
Article Number: 160
Published online on: 20 July 2026

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Article Open Access

M2‑TAM‑derived exosomal miR‑491‑3p modulates UBE2D3 and promotes the proliferation, migration and invasion of lung cancer cells

Qiang Zhang, Yungang Sun, Yu Zhuang, Shiwei Xu, Mengxu Yao, Siyang Jiao, Qi Wang, Feng Shao, Xiaoying Zhang
Article Number: 159
Published online on: 17 July 2026

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Correction Open Access

[Corrigendum] Emodin attenuated severe acute pancreatitis via the P2X ligand‑gated ion channel 7/NOD‑like receptor protein 3 signaling pathway

Qingkai Zhang, Xufeng Tao, Shilin Xia, Jialin Qu, Huiyi Song, Jianjun Liu, Hailong Li, Dong Shang
Article Number: 158
Published online on: 15 July 2026

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Article Open Access

TM6SF2 overexpression suppresses the proliferation and promotes apoptosis of human hepatocellular carcinoma cells

Ziyou Huai, Wanying Xue, Xinxiao Jin, Shiyu Peng, Wenqiang Xu, Shujing Li, Huanfeng Hao, Yuanyuan Wang
Article Number: 157
Published online on: 14 July 2026

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Correction Open Access

[Corrigendum] VDAC upregulation and αTAT1‑mediated α‑tubulin acetylation contribute to tanespimycin‑induced apoptosis in Calu‑1 cells

Qilin Wang, Xiangguo Liu
Article Number: 156
Published online on: 13 July 2026

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Retraction Open Access

[Retracted] Synergistic cytotoxic effects of inorganic phosphate and chemotherapeutic drugs on human osteosarcoma cells

Annamaria Spina, Luca Sorvillo, Emilio Chiosi, Antonietta Esposito, Francesca Di Maiolo, Luigi Sapio, Michele Caraglia, Silvio Naviglio
Article Number: 155
Published online on: 06 July 2026

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Article Open Access

Identification of RRM2 as a key regulator of malignant epithelial cells in gastric cancer through single‑cell transcriptomics

Xinzhen Cai, Yun He, Lili Kang, Dongli Zhou, Mengmeng Wang, Tianyu Ma
Article Number: 154
Published online on: 03 July 2026

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Article

Impact of WFDC2 on the biological functions of cervical cancer cells and the regulation of the ERK/NF‑κB signaling pathway

Yanping Zhang, Hongling Zou, Shufeng Deng, Lvling Zou, Mingzhu Xia, Limin Tao
Article Number: 153
Published online on: 01 July 2026

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Journal Cover
October-2026 Volume 56 Issue 4

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Journal Metrics

Impact Factor: 4.7

CiteScore: 7.7

CiteScore Rank: Q1: #76/428 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Correction Open Access

[Corrigendum] Knockdown of Bmi1 inhibits the stemness properties and tumorigenicity of human bladder cancer stem cell‑like side population cells

Dingjun Zhu, Xuesi Wan, Hai Huang, Xu Chen, Wu Liang, Fengjin Zhao, Tianxin Lin, Jinli Han, Wenlian Xie
Article Number: 171
Published online on: 10 August 2026

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Review Open Access

Polyphenol‑based interventions in breast cancer: Signaling pathways, molecular mechanisms and translational therapeutic strategies (Review)

Jingjing Zeng, Jinyan Hu, Zhiyuan Ma, Suansuan Zhu, Xiangling Lv, Lanhai Zhang, Mimi Shen, Taolang Li
Article Number: 170
Published online on: 07 August 2026

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Article Open Access

HDAC1 promotes lung adenocarcinoma progression via the nuclear accumulation of β‑catenin

Shijie Xu, Xiaolu Chang, Xiayu Wu, Fabao Wang, Jing Xiang, Chaoxiang Lin, He Zhao, Junzhe Li, Xianhua Xu
Article Number: 169
Published online on: 07 August 2026

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Retraction Open Access

[Retracted] MicroRNA‑365 inhibits proliferation, migration and invasion of glioma by targeting PIK3R3

Yonggang Zhu, Hongguang Zhao, Min Rao, Songbai Xu
Article Number: 168
Published online on: 27 July 2026

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Review Open Access

CTGF: The remodeler of the tumor immune microenvironment (Review)

Ying Zhao, Li Han, Qingyu Wu, Haiying Li, Fuhong Dai
Article Number: 167
Published online on: 24 July 2026

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Anticancer effects of tangeretin associated with reactive oxygen species generation, mitochondrial dysfunction and apoptosis in CaSki cells

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Article Number: 166
Published online on: 24 July 2026

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Article Open Access

Stable overexpression of Nup88 enhances HeLa cell migration through independent regulation of Kif7 and Gli1

Masaki Makise, Ryota Uchimura, Ayano Shiraishi, Akihiko Kuniyasu
Article Number: 165
Published online on: 24 July 2026

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TPD54 contributes to docetaxel resistance through modulation of P‑glycoprotein localization and activity in oral squamous cell carcinoma cells

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Article Number: 164
Published online on: 24 July 2026

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