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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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November 2009 Volume 22 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 2009 Volume 22 Issue 5

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Article

Different expression of mimecan as a marker for differential diagnosis between NSCLC and SCLC

  • Authors:
    • Cui-Xia Zheng
    • Shuang-Xia Zhao
    • Ping Wang
    • Hui-Min Yu
    • Cao-Fu Wang
    • Bing Han
    • Bin Su
    • Yi Xiang
    • Xue-Song Li
    • Sheng-Xian Li
    • Qin-Yun Ma
    • Rong-Xin Zhang
    • Huan-Ying Wan
    • Huai-Dong Song

  • View Affiliations / Copyright

    Affiliations: The Ninth Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, P.R. China. zcx9566@163.com
  • Pages: 1057-1061
    |
    Published online on: November 1, 2009
       https://doi.org/10.3892/or_00000536
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Abstract

Mimecan mRNA was present in a limited number of mouse and human tissues, however, abundant mimecan mRNA was observed in the lung tissue. Therefore, we hypothesize that mimecan could serve as a biomarker for differentiating various histological types of lung cancers. In humans, the mimecan mRNA was found most abundant in ovary and less abundant in lung by using Northern blot analysis. Moreover, the mimecan was expressed strongly in the epithelial cells of the bronchial wall and weaker in the epithelial cells of the alveolar sacs by in situ hybridization and immunohistochemical analysis. Furthermore, the mimecan immunoreactivity was found in 103 (97.2%) of 106 non-small cell lung cancers (NSCLCs). Nevertheless, a large majority of small cell lung cancers (SCLCs) (50/56, 89.3%) showed negative immunoreactivity to mimecan polyclonal antibody. A significant difference of mimecan immunoreactivity was found between NSCLC and SCLC (P<0.00001). This is the first study showing that mimecan could serve as an excellent pathological biomarker to distinguish NSCLCs from SCLCs.

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Copy and paste a formatted citation
Spandidos Publications style
Zheng C, Zhao S, Wang P, Yu H, Wang C, Han B, Su B, Xiang Y, Li X, Li S, Li S, et al: Different expression of mimecan as a marker for differential diagnosis between NSCLC and SCLC. Oncol Rep 22: 1057-1061, 2009.
APA
Zheng, C., Zhao, S., Wang, P., Yu, H., Wang, C., Han, B. ... Song, H. (2009). Different expression of mimecan as a marker for differential diagnosis between NSCLC and SCLC. Oncology Reports, 22, 1057-1061. https://doi.org/10.3892/or_00000536
MLA
Zheng, C., Zhao, S., Wang, P., Yu, H., Wang, C., Han, B., Su, B., Xiang, Y., Li, X., Li, S., Ma, Q., Zhang, R., Wan, H., Song, H."Different expression of mimecan as a marker for differential diagnosis between NSCLC and SCLC". Oncology Reports 22.5 (2009): 1057-1061.
Chicago
Zheng, C., Zhao, S., Wang, P., Yu, H., Wang, C., Han, B., Su, B., Xiang, Y., Li, X., Li, S., Ma, Q., Zhang, R., Wan, H., Song, H."Different expression of mimecan as a marker for differential diagnosis between NSCLC and SCLC". Oncology Reports 22, no. 5 (2009): 1057-1061. https://doi.org/10.3892/or_00000536
Copy and paste a formatted citation
x
Spandidos Publications style
Zheng C, Zhao S, Wang P, Yu H, Wang C, Han B, Su B, Xiang Y, Li X, Li S, Li S, et al: Different expression of mimecan as a marker for differential diagnosis between NSCLC and SCLC. Oncol Rep 22: 1057-1061, 2009.
APA
Zheng, C., Zhao, S., Wang, P., Yu, H., Wang, C., Han, B. ... Song, H. (2009). Different expression of mimecan as a marker for differential diagnosis between NSCLC and SCLC. Oncology Reports, 22, 1057-1061. https://doi.org/10.3892/or_00000536
MLA
Zheng, C., Zhao, S., Wang, P., Yu, H., Wang, C., Han, B., Su, B., Xiang, Y., Li, X., Li, S., Ma, Q., Zhang, R., Wan, H., Song, H."Different expression of mimecan as a marker for differential diagnosis between NSCLC and SCLC". Oncology Reports 22.5 (2009): 1057-1061.
Chicago
Zheng, C., Zhao, S., Wang, P., Yu, H., Wang, C., Han, B., Su, B., Xiang, Y., Li, X., Li, S., Ma, Q., Zhang, R., Wan, H., Song, H."Different expression of mimecan as a marker for differential diagnosis between NSCLC and SCLC". Oncology Reports 22, no. 5 (2009): 1057-1061. https://doi.org/10.3892/or_00000536
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