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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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November 2009 Volume 22 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 2009 Volume 22 Issue 5

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Article

Enhancement of DNA cancer vaccine efficacy by combination with anti-angiogenesis in regression of established subcutaneous B16 melanoma

  • Authors:
    • Ray Chun-Fai Chan
    • Benjamin Gutierrez
    • Thomas E. Ichim
    • Feng Lin
  • View Affiliations / Copyright

    Affiliations: Department of Research and Development, Inovio Biomedical Corporation, San Diego, CA 92121-1318, USA
  • Pages: 1197-1203
    |
    Published online on: November 1, 2009
       https://doi.org/10.3892/or_00000555
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Abstract

Immunotherapy of cancer offers great promise, however translation into human studies has yielded relatively poor results to date. The concept of combining cancer vaccination with angiogenesis inhibition is appealing, due to favorable safety profile of both approaches, as well as possible biological synergies. Here we studied the anti-tumor effects of combining plasmid DNA (pDNA) vaccination and anti-angiogenesis in B16F10 murine model. By using electroporation-mediated gene/pDNA delivery, the anti-tumor efficacy of vaccination with pDNAs encoding gp100, TRP2 and Ii-PADRE was facilitated by administration of soluble form of EphB4 fused with human serum albumin (sEphB4-HSA), or by co-delivery of pDNAs encoding Angiostatin and/or Endostatin. In an optimized administration protocol, melanoma vaccination together with intratumoral delivery of pDNAs encoding Angiostatin and Endostatin resulted in 57% tumor-free survival over 90 days after challenge. These data support the general concept that suppression of angiogenesis may allow for enhanced efficacy of anti-tumor immunity, suggesting the synergetic effects of therapeutic pDNA vaccination and angiogenesis inhibition in cancer therapy.

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Copy and paste a formatted citation
Spandidos Publications style
Chan RC, Gutierrez B, Ichim TE and Lin F: Enhancement of DNA cancer vaccine efficacy by combination with anti-angiogenesis in regression of established subcutaneous B16 melanoma. Oncol Rep 22: 1197-1203, 2009.
APA
Chan, R.C., Gutierrez, B., Ichim, T.E., & Lin, F. (2009). Enhancement of DNA cancer vaccine efficacy by combination with anti-angiogenesis in regression of established subcutaneous B16 melanoma. Oncology Reports, 22, 1197-1203. https://doi.org/10.3892/or_00000555
MLA
Chan, R. C., Gutierrez, B., Ichim, T. E., Lin, F."Enhancement of DNA cancer vaccine efficacy by combination with anti-angiogenesis in regression of established subcutaneous B16 melanoma". Oncology Reports 22.5 (2009): 1197-1203.
Chicago
Chan, R. C., Gutierrez, B., Ichim, T. E., Lin, F."Enhancement of DNA cancer vaccine efficacy by combination with anti-angiogenesis in regression of established subcutaneous B16 melanoma". Oncology Reports 22, no. 5 (2009): 1197-1203. https://doi.org/10.3892/or_00000555
Copy and paste a formatted citation
x
Spandidos Publications style
Chan RC, Gutierrez B, Ichim TE and Lin F: Enhancement of DNA cancer vaccine efficacy by combination with anti-angiogenesis in regression of established subcutaneous B16 melanoma. Oncol Rep 22: 1197-1203, 2009.
APA
Chan, R.C., Gutierrez, B., Ichim, T.E., & Lin, F. (2009). Enhancement of DNA cancer vaccine efficacy by combination with anti-angiogenesis in regression of established subcutaneous B16 melanoma. Oncology Reports, 22, 1197-1203. https://doi.org/10.3892/or_00000555
MLA
Chan, R. C., Gutierrez, B., Ichim, T. E., Lin, F."Enhancement of DNA cancer vaccine efficacy by combination with anti-angiogenesis in regression of established subcutaneous B16 melanoma". Oncology Reports 22.5 (2009): 1197-1203.
Chicago
Chan, R. C., Gutierrez, B., Ichim, T. E., Lin, F."Enhancement of DNA cancer vaccine efficacy by combination with anti-angiogenesis in regression of established subcutaneous B16 melanoma". Oncology Reports 22, no. 5 (2009): 1197-1203. https://doi.org/10.3892/or_00000555
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