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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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December 2009 Volume 22 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article Open Access

Modulation of MMP-2 and MMP-9 by cytokines, mitogens and inhibitors in lung cancer and malignant mesothelioma cell lines

  • Authors:
    • M. W. Roomi
    • Julio C. Monterrey
    • Tatiana Kalinovsky
    • Aleksandra Niedzwiecki
    • Matthias Rath

  • View Affiliations / Copyright

    Affiliations: Dr. Rath Research Institute, Santa Clara, CA 95050, USA
  • Pages: 1283-1291
    |
    Published online on: December 1, 2009
       https://doi.org/10.3892/or_00000566
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Abstract

Matrix metalloproteinases (MMPs) secreted by lung cancer (LC) and malignant mesothelioma (MM), especially MMP-2 and MMP-9, play crucial roles in tumor invasion and metastasis. We examined the effect of cytokines, mitogens and inhibitors on MMP-2 and MMP-9 expression in LC and MM cell lines. Human LC (A-549) and MM (MSTO-211H) cell lines were cultured in appropriate media. At near confluence, the cells were washed with PBS and incubated in serum-free medium with various concentrations of several cytokines, mitogens and inhibitors. After 24 h the media were removed and analyzed for MMP-2 and MMP-9 by gelatinase zymography and quantitated by densitometry. LC expressed MMP-2 whereas MM expressed MMP-2 and MMP-9. TNF-α, IL-1β, LPS and PMA, stimulated MMP-2 in LC and inhibited MMP-2 in MM, but had no effect on MMP-9. Doxycycline, EGCG and NM inhibited MMP-2 and MMP-9 expression, in both cell lines. Actinomycin-D, cyclohexamide, retinoic acid and dexamethasone inhibited MMP-2 in both cancer cell lines and inhibited MMP-9 in MM. Our results show that cytokines and inhibitors have an up- or down-regulatory effect on MMP-2 and MMP-9 expression in LC and MM, suggesting the clinical value of targeting these proteases for management of LC and MM and their pathogenesis.

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Copy and paste a formatted citation
Spandidos Publications style
Roomi MW, Monterrey JC, Kalinovsky T, Niedzwiecki A and Rath M: Modulation of MMP-2 and MMP-9 by cytokines, mitogens and inhibitors in lung cancer and malignant mesothelioma cell lines. Oncol Rep 22: 1283-1291, 2009.
APA
Roomi, M.W., Monterrey, J.C., Kalinovsky, T., Niedzwiecki, A., & Rath, M. (2009). Modulation of MMP-2 and MMP-9 by cytokines, mitogens and inhibitors in lung cancer and malignant mesothelioma cell lines. Oncology Reports, 22, 1283-1291. https://doi.org/10.3892/or_00000566
MLA
Roomi, M. W., Monterrey, J. C., Kalinovsky, T., Niedzwiecki, A., Rath, M."Modulation of MMP-2 and MMP-9 by cytokines, mitogens and inhibitors in lung cancer and malignant mesothelioma cell lines". Oncology Reports 22.6 (2009): 1283-1291.
Chicago
Roomi, M. W., Monterrey, J. C., Kalinovsky, T., Niedzwiecki, A., Rath, M."Modulation of MMP-2 and MMP-9 by cytokines, mitogens and inhibitors in lung cancer and malignant mesothelioma cell lines". Oncology Reports 22, no. 6 (2009): 1283-1291. https://doi.org/10.3892/or_00000566
Copy and paste a formatted citation
x
Spandidos Publications style
Roomi MW, Monterrey JC, Kalinovsky T, Niedzwiecki A and Rath M: Modulation of MMP-2 and MMP-9 by cytokines, mitogens and inhibitors in lung cancer and malignant mesothelioma cell lines. Oncol Rep 22: 1283-1291, 2009.
APA
Roomi, M.W., Monterrey, J.C., Kalinovsky, T., Niedzwiecki, A., & Rath, M. (2009). Modulation of MMP-2 and MMP-9 by cytokines, mitogens and inhibitors in lung cancer and malignant mesothelioma cell lines. Oncology Reports, 22, 1283-1291. https://doi.org/10.3892/or_00000566
MLA
Roomi, M. W., Monterrey, J. C., Kalinovsky, T., Niedzwiecki, A., Rath, M."Modulation of MMP-2 and MMP-9 by cytokines, mitogens and inhibitors in lung cancer and malignant mesothelioma cell lines". Oncology Reports 22.6 (2009): 1283-1291.
Chicago
Roomi, M. W., Monterrey, J. C., Kalinovsky, T., Niedzwiecki, A., Rath, M."Modulation of MMP-2 and MMP-9 by cytokines, mitogens and inhibitors in lung cancer and malignant mesothelioma cell lines". Oncology Reports 22, no. 6 (2009): 1283-1291. https://doi.org/10.3892/or_00000566
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