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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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December 2009 Volume 22 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

Positive correlation between cyclooxygenase-2 and ABC-transporter expression in non-Hodgkin's lymphomas

  • Authors:
    • Katarzyna Szczuraszek
    • Verena Materna
    • Agnieszka Halon
    • Grzegorz Mazur
    • Tomasz Wróbel
    • Kazimierz Kuliczkowski
    • Adam Maciejczyk
    • Maciej Zabel
    • Marcin Drag
    • Manfred Dietel
    • Hermann Lage
    • Pawel Surowiak

  • View Affiliations / Copyright

    Affiliations: Department of Histology and Embryology, University School of Medicine, 50-356 Wroclaw, Poland
  • Pages: 1315-1323
    |
    Published online on: December 1, 2009
       https://doi.org/10.3892/or_00000570
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Abstract

One of the leading causes of chemotherapy failure in non-Hodgkin's lymphomas (NHLs) is multidrug resistance (MDR). MDR can be associated with expression of members of the family of ABC-transporters. Since a correlation between expression of cyclooxygenase-2 (COX-2) and MDR in various cancer cells was described, the expression of COX-2 and the ABC-transporters MDR1/P-glycoprotein (P-gp), MRP1, MRP2 and BCRP was examined in 56 previously non-treated patients by immunohistochemistry. The data show that: i) P-gp is not expressed in non-treated NHLs; ii) MRP2 can be localized in the nuclear membranes of NHL cells; iii) expression of MRP2 in the cytoplasm membrane correlates with clinical response; iv) elevated expression of BCRP is typical for the patients, who did not respond to primary chemotherapy and for cases with shorter progression-free survival time in a 30 months follow-up; and v) there is a strong correlation between COX-2 and MRP1, MRP2 and BCRP. It can be concluded that: i) BCRP may be a crucial factor involved in primary resistance of NHLs, thus it may be useful for prediction of chemotherapeutic treatment and risk of relapse; and ii) since there is strong correlation between COX-2 expression and MDR in NHLs, the application of COX-2 inhibitors may be considered for chemosensitization.

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Copy and paste a formatted citation
Spandidos Publications style
Szczuraszek K, Materna V, Halon A, Mazur G, Wróbel T, Kuliczkowski K, Maciejczyk A, Zabel M, Drag M, Dietel M, Dietel M, et al: Positive correlation between cyclooxygenase-2 and ABC-transporter expression in non-Hodgkin's lymphomas. Oncol Rep 22: 1315-1323, 2009.
APA
Szczuraszek, K., Materna, V., Halon, A., Mazur, G., Wróbel, T., Kuliczkowski, K. ... Surowiak, P. (2009). Positive correlation between cyclooxygenase-2 and ABC-transporter expression in non-Hodgkin's lymphomas. Oncology Reports, 22, 1315-1323. https://doi.org/10.3892/or_00000570
MLA
Szczuraszek, K., Materna, V., Halon, A., Mazur, G., Wróbel, T., Kuliczkowski, K., Maciejczyk, A., Zabel, M., Drag, M., Dietel, M., Lage, H., Surowiak, P."Positive correlation between cyclooxygenase-2 and ABC-transporter expression in non-Hodgkin's lymphomas". Oncology Reports 22.6 (2009): 1315-1323.
Chicago
Szczuraszek, K., Materna, V., Halon, A., Mazur, G., Wróbel, T., Kuliczkowski, K., Maciejczyk, A., Zabel, M., Drag, M., Dietel, M., Lage, H., Surowiak, P."Positive correlation between cyclooxygenase-2 and ABC-transporter expression in non-Hodgkin's lymphomas". Oncology Reports 22, no. 6 (2009): 1315-1323. https://doi.org/10.3892/or_00000570
Copy and paste a formatted citation
x
Spandidos Publications style
Szczuraszek K, Materna V, Halon A, Mazur G, Wróbel T, Kuliczkowski K, Maciejczyk A, Zabel M, Drag M, Dietel M, Dietel M, et al: Positive correlation between cyclooxygenase-2 and ABC-transporter expression in non-Hodgkin's lymphomas. Oncol Rep 22: 1315-1323, 2009.
APA
Szczuraszek, K., Materna, V., Halon, A., Mazur, G., Wróbel, T., Kuliczkowski, K. ... Surowiak, P. (2009). Positive correlation between cyclooxygenase-2 and ABC-transporter expression in non-Hodgkin's lymphomas. Oncology Reports, 22, 1315-1323. https://doi.org/10.3892/or_00000570
MLA
Szczuraszek, K., Materna, V., Halon, A., Mazur, G., Wróbel, T., Kuliczkowski, K., Maciejczyk, A., Zabel, M., Drag, M., Dietel, M., Lage, H., Surowiak, P."Positive correlation between cyclooxygenase-2 and ABC-transporter expression in non-Hodgkin's lymphomas". Oncology Reports 22.6 (2009): 1315-1323.
Chicago
Szczuraszek, K., Materna, V., Halon, A., Mazur, G., Wróbel, T., Kuliczkowski, K., Maciejczyk, A., Zabel, M., Drag, M., Dietel, M., Lage, H., Surowiak, P."Positive correlation between cyclooxygenase-2 and ABC-transporter expression in non-Hodgkin's lymphomas". Oncology Reports 22, no. 6 (2009): 1315-1323. https://doi.org/10.3892/or_00000570
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