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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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December 2009 Volume 22 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2009 Volume 22 Issue 6

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Article

Inhibition of prostate cancer by suicide gene targeting the FCY1 and HSV-TK genes

  • Authors:
    • Qiao-Hong Yue
    • Xing-Bin Hu
    • Ying Yin
    • Ming-Quan Su
    • Xiao-Dong Cheng
    • Liu Yang
    • Tie-Cheng Zhou
    • Xiaoke Hao

  • View Affiliations / Copyright

    Affiliations: Department of Clinic Molecular Research Center and Clinic Diagnostic Laboratory, Xijing Hospital, the Fourth Military Medical University, Xi'an 710032, P.R. China
  • Pages: 1341-1347
    |
    Published online on: December 1, 2009
       https://doi.org/10.3892/or_00000573
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Abstract

Prostate cancer is one of the most prevalent tumors. The switch of androgen signal dependence makes therapy more complex. Although reports on introduction of a single suicide gene exist, double suicide gene therapy has not been reported yet. In the current study, two suicide genes were constructed in the pIRES plasmid driven by PSMA promoter. 5-FC and GCV combination in vitro led to a higher growth inhibition on prostate cancer compared to a single pro-drug. Retarded xenograft tumor growth was observed in castrated nude mice after double suicide gene activation. Furthermore, decreased metastasis was observed with double suicide gene treatment. These findings suggest that specific double suicide gene strategy could be a potential option for the therapy of prostate cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Yue Q, Hu X, Yin Y, Su M, Cheng X, Yang L, Zhou T and Hao X: Inhibition of prostate cancer by suicide gene targeting the FCY1 and HSV-TK genes. Oncol Rep 22: 1341-1347, 2009.
APA
Yue, Q., Hu, X., Yin, Y., Su, M., Cheng, X., Yang, L. ... Hao, X. (2009). Inhibition of prostate cancer by suicide gene targeting the FCY1 and HSV-TK genes. Oncology Reports, 22, 1341-1347. https://doi.org/10.3892/or_00000573
MLA
Yue, Q., Hu, X., Yin, Y., Su, M., Cheng, X., Yang, L., Zhou, T., Hao, X."Inhibition of prostate cancer by suicide gene targeting the FCY1 and HSV-TK genes". Oncology Reports 22.6 (2009): 1341-1347.
Chicago
Yue, Q., Hu, X., Yin, Y., Su, M., Cheng, X., Yang, L., Zhou, T., Hao, X."Inhibition of prostate cancer by suicide gene targeting the FCY1 and HSV-TK genes". Oncology Reports 22, no. 6 (2009): 1341-1347. https://doi.org/10.3892/or_00000573
Copy and paste a formatted citation
x
Spandidos Publications style
Yue Q, Hu X, Yin Y, Su M, Cheng X, Yang L, Zhou T and Hao X: Inhibition of prostate cancer by suicide gene targeting the FCY1 and HSV-TK genes. Oncol Rep 22: 1341-1347, 2009.
APA
Yue, Q., Hu, X., Yin, Y., Su, M., Cheng, X., Yang, L. ... Hao, X. (2009). Inhibition of prostate cancer by suicide gene targeting the FCY1 and HSV-TK genes. Oncology Reports, 22, 1341-1347. https://doi.org/10.3892/or_00000573
MLA
Yue, Q., Hu, X., Yin, Y., Su, M., Cheng, X., Yang, L., Zhou, T., Hao, X."Inhibition of prostate cancer by suicide gene targeting the FCY1 and HSV-TK genes". Oncology Reports 22.6 (2009): 1341-1347.
Chicago
Yue, Q., Hu, X., Yin, Y., Su, M., Cheng, X., Yang, L., Zhou, T., Hao, X."Inhibition of prostate cancer by suicide gene targeting the FCY1 and HSV-TK genes". Oncology Reports 22, no. 6 (2009): 1341-1347. https://doi.org/10.3892/or_00000573
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