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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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December 2009 Volume 22 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2009 Volume 22 Issue 6

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Article

Effect of 5-ALA-PDT on VEGF and PCNA expression in human NPC-bearing nude mice

  • Authors:
    • Ying Xie
    • Zheng-Bo Wei
    • Zhe Zhang
    • Wensheng Wen
    • Guang-Wu Huang

  • View Affiliations / Copyright

    Affiliations: Department of GuangXi Experimental Center of Medical Sciences, Nanning 530021, P.R. China
  • Pages: 1365-1371
    |
    Published online on: December 1, 2009
       https://doi.org/10.3892/or_00000576
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Abstract

Photodynamic therapy (PDT) is a promising treatment for nasopharyngeal carcinoma. However, recurrence and metastasis of the tumor after PDT remains problematic. In this study we investigated VEGF and PCNA expression in tumor tissues after 5-ALA-PDT. BALB/c nude mice with NPC tumors of similar size were randomly assigned to three groups (n=10 each). In the two treatment groups, mice were administrated 5-ALA intratumorally at a dose of 100 mg/kg and 3-3.5 h prior to laser irradiation (630 nm, 100 J/cm2, 100 mW/cm2). The mice in one of the treatment groups were sacrificed at 24 h after PDT. The other treatment group and control group mice were sacrificed 14 days after PDT, and the tumor weights were determined for all three groups. Mean tumor weights at 14 days after PDT were 1.353±0.204 g in the treatment group and 3.124±0.380 g in the control group (p<0.001). Results showed the VEGF level in tumor tissues at 24 h after PDT was slightly higher than that in the control group, while it was down-regulated at 14 days after PDT. The PCNA level was not significantly different in tumor tissues among the three groups, but it was lower in degenerated tumor cells 24 h after PDT. Our results suggest that VEGF may play a role in tumor recurrence and metastasis following PDT. Residual tumor cells escaped from PDT is the main reason for tumor recurrence.

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Copy and paste a formatted citation
Spandidos Publications style
Xie Y, Wei Z, Zhang Z, Wen W and Huang G: Effect of 5-ALA-PDT on VEGF and PCNA expression in human NPC-bearing nude mice. Oncol Rep 22: 1365-1371, 2009.
APA
Xie, Y., Wei, Z., Zhang, Z., Wen, W., & Huang, G. (2009). Effect of 5-ALA-PDT on VEGF and PCNA expression in human NPC-bearing nude mice. Oncology Reports, 22, 1365-1371. https://doi.org/10.3892/or_00000576
MLA
Xie, Y., Wei, Z., Zhang, Z., Wen, W., Huang, G."Effect of 5-ALA-PDT on VEGF and PCNA expression in human NPC-bearing nude mice". Oncology Reports 22.6 (2009): 1365-1371.
Chicago
Xie, Y., Wei, Z., Zhang, Z., Wen, W., Huang, G."Effect of 5-ALA-PDT on VEGF and PCNA expression in human NPC-bearing nude mice". Oncology Reports 22, no. 6 (2009): 1365-1371. https://doi.org/10.3892/or_00000576
Copy and paste a formatted citation
x
Spandidos Publications style
Xie Y, Wei Z, Zhang Z, Wen W and Huang G: Effect of 5-ALA-PDT on VEGF and PCNA expression in human NPC-bearing nude mice. Oncol Rep 22: 1365-1371, 2009.
APA
Xie, Y., Wei, Z., Zhang, Z., Wen, W., & Huang, G. (2009). Effect of 5-ALA-PDT on VEGF and PCNA expression in human NPC-bearing nude mice. Oncology Reports, 22, 1365-1371. https://doi.org/10.3892/or_00000576
MLA
Xie, Y., Wei, Z., Zhang, Z., Wen, W., Huang, G."Effect of 5-ALA-PDT on VEGF and PCNA expression in human NPC-bearing nude mice". Oncology Reports 22.6 (2009): 1365-1371.
Chicago
Xie, Y., Wei, Z., Zhang, Z., Wen, W., Huang, G."Effect of 5-ALA-PDT on VEGF and PCNA expression in human NPC-bearing nude mice". Oncology Reports 22, no. 6 (2009): 1365-1371. https://doi.org/10.3892/or_00000576
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