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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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December 2009 Volume 22 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2009 Volume 22 Issue 6

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Article

Depletion of PI3K p85α induces cell cycle arrest and apoptosis in colorectal cancer cells

  • Authors:
    • Yan Sun
    • Shiyi Zhao
    • Hua Tian
    • Xiaoyun Xie
    • Faman Xiao
    • Kang Li
    • Yugang Song

  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, P.R. China
  • Pages: 1435-1441
    |
    Published online on: December 1, 2009
       https://doi.org/10.3892/or_00000585
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Abstract

Colorectal cancer is one of the most common malignancies in the world. Overactivity of phosphatidylinositol 3-kinase (PI3K) is frequently detected in colorectal carcinoma. PI3K signaling plays a pivotal role in intracellular signal transduction pathways involved in cell growth, cellular transformation, and tumorigenesis. To specifically inhibit PI3K activity in colorectal cancer cells, we constructed a siRNA against the PI3K regulatory subunit p85α and transfected it into LoVo and SW480 cells. In the present study, treatment of colorectal cancer cells with PI3K p85α-specific siRNA inhibited cell proliferation, induced G1 phase cell cycle arrest and sensitized colorectal cancer cells to 5-FU-induced apoptosis. Furthermore, depletion of PI3K p85α resulted in significant activation of three Forkhead box class O (FoxO) transcription factors, which inhibited the expression of cyclin D1, cdk4 and induced expression of p27/Kip1. Activation of FoxO transcription factors also increased the expression of FasL. Thus, our results indicate that siRNA-mediated gene silencing of PI3K p85α may be a useful therapeutic strategy for colorectal carcinoma.

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Copy and paste a formatted citation
Spandidos Publications style
Sun Y, Zhao S, Tian H, Xie X, Xiao F, Li K and Song Y: Depletion of PI3K p85α induces cell cycle arrest and apoptosis in colorectal cancer cells . Oncol Rep 22: 1435-1441, 2009.
APA
Sun, Y., Zhao, S., Tian, H., Xie, X., Xiao, F., Li, K., & Song, Y. (2009). Depletion of PI3K p85α induces cell cycle arrest and apoptosis in colorectal cancer cells . Oncology Reports, 22, 1435-1441. https://doi.org/10.3892/or_00000585
MLA
Sun, Y., Zhao, S., Tian, H., Xie, X., Xiao, F., Li, K., Song, Y."Depletion of PI3K p85α induces cell cycle arrest and apoptosis in colorectal cancer cells ". Oncology Reports 22.6 (2009): 1435-1441.
Chicago
Sun, Y., Zhao, S., Tian, H., Xie, X., Xiao, F., Li, K., Song, Y."Depletion of PI3K p85α induces cell cycle arrest and apoptosis in colorectal cancer cells ". Oncology Reports 22, no. 6 (2009): 1435-1441. https://doi.org/10.3892/or_00000585
Copy and paste a formatted citation
x
Spandidos Publications style
Sun Y, Zhao S, Tian H, Xie X, Xiao F, Li K and Song Y: Depletion of PI3K p85α induces cell cycle arrest and apoptosis in colorectal cancer cells . Oncol Rep 22: 1435-1441, 2009.
APA
Sun, Y., Zhao, S., Tian, H., Xie, X., Xiao, F., Li, K., & Song, Y. (2009). Depletion of PI3K p85α induces cell cycle arrest and apoptosis in colorectal cancer cells . Oncology Reports, 22, 1435-1441. https://doi.org/10.3892/or_00000585
MLA
Sun, Y., Zhao, S., Tian, H., Xie, X., Xiao, F., Li, K., Song, Y."Depletion of PI3K p85α induces cell cycle arrest and apoptosis in colorectal cancer cells ". Oncology Reports 22.6 (2009): 1435-1441.
Chicago
Sun, Y., Zhao, S., Tian, H., Xie, X., Xiao, F., Li, K., Song, Y."Depletion of PI3K p85α induces cell cycle arrest and apoptosis in colorectal cancer cells ". Oncology Reports 22, no. 6 (2009): 1435-1441. https://doi.org/10.3892/or_00000585
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