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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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January 2010 Volume 23 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Na+/H+ exchanger blockade inhibits the expression of vascular endothelial growth factor in SGC7901 cells

  • Authors:
    • Bingyan He
    • Ming Zhang
    • Rui Zhu
  • View Affiliations / Copyright

    Affiliations: Department of Pediatrics, Zhongnan hospital of Wuhan University, Wuhan 430071, Hubei Province, P.R. China. heby2005@sina.com
  • Pages: 79-87
    |
    Published online on: January 1, 2010
       https://doi.org/10.3892/or_00000608
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Abstract

Vascular endothelial growth factor (VEGF) overexpression is critically involved in tumor formation. Na+/H+ exchanger isoform (NHE) is elevated in cancer cells. We explored the effect of NHE inhibition on VEGF expression in human gastric cancer SGC7901 cells. VEGF mRNA expression was detected by real-time RT-PCR. VEGF protein expression was measured by western blotting and immunocytochemistry. For determination of viable cells the MTT colorimetric assay was used. Treatment of SGC7901 cells with NHE inhibitors resulted in significant decrease of VEGF mRNA and protein expression. NHE inhibition decreased intracellular pH (pHi) values and VEGF mRNA expression. These data demonstrate that NHE blockade inhibits VEGF expression in SGC7901 cells.

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Copy and paste a formatted citation
Spandidos Publications style
He B, Zhang M and Zhu R: Na+/H+ exchanger blockade inhibits the expression of vascular endothelial growth factor in SGC7901 cells. Oncol Rep 23: 79-87, 2010.
APA
He, B., Zhang, M., & Zhu, R. (2010). Na+/H+ exchanger blockade inhibits the expression of vascular endothelial growth factor in SGC7901 cells. Oncology Reports, 23, 79-87. https://doi.org/10.3892/or_00000608
MLA
He, B., Zhang, M., Zhu, R."Na+/H+ exchanger blockade inhibits the expression of vascular endothelial growth factor in SGC7901 cells". Oncology Reports 23.1 (2010): 79-87.
Chicago
He, B., Zhang, M., Zhu, R."Na+/H+ exchanger blockade inhibits the expression of vascular endothelial growth factor in SGC7901 cells". Oncology Reports 23, no. 1 (2010): 79-87. https://doi.org/10.3892/or_00000608
Copy and paste a formatted citation
x
Spandidos Publications style
He B, Zhang M and Zhu R: Na+/H+ exchanger blockade inhibits the expression of vascular endothelial growth factor in SGC7901 cells. Oncol Rep 23: 79-87, 2010.
APA
He, B., Zhang, M., & Zhu, R. (2010). Na+/H+ exchanger blockade inhibits the expression of vascular endothelial growth factor in SGC7901 cells. Oncology Reports, 23, 79-87. https://doi.org/10.3892/or_00000608
MLA
He, B., Zhang, M., Zhu, R."Na+/H+ exchanger blockade inhibits the expression of vascular endothelial growth factor in SGC7901 cells". Oncology Reports 23.1 (2010): 79-87.
Chicago
He, B., Zhang, M., Zhu, R."Na+/H+ exchanger blockade inhibits the expression of vascular endothelial growth factor in SGC7901 cells". Oncology Reports 23, no. 1 (2010): 79-87. https://doi.org/10.3892/or_00000608
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