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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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January 2010 Volume 23 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 2010 Volume 23 Issue 1

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Article

The mitogenic effectors of isoproterenol in human hepatocellular carcinoma cells

  • Authors:
    • Aihua Yuan
    • Zongfang Li
    • Xinqiu Li
    • Shanyong Yi
    • Shukui Wang
    • Yongdong Cai
    • Hongyong Cao

  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Nanjing First Hospital Affiliated to Nanjing Medical University, Nanjing 210006, P.R. China. chineseyah2008@yahoo.cn
  • Pages: 151-157
    |
    Published online on: January 1, 2010
       https://doi.org/10.3892/or_00000616
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Abstract

Increasing data indicate that stress hormones and their corresponding receptors play an important role in the carcinogenesis and progression of hepatocellular carcinoma (HCC). However, there is presently no study investigating the influence of stress hormones in correlation with β2-AR on human HCC cells. We examined the expression of α1- and β-ARs in human HCC cell line HepG2 and MHCC97H cells in comparison with that in human normal hepatic cell line HL-7702 cells (L-02), and the influence of isoproterenol (ISO) on the growth of these HCC cells using blocking agents in correlation with β2-AR and its downstream signaling pathways. We found that α1-AR was down-regulated and β2-AR was up-regulated in HepG2 and MHCC97H cells. ISO dose-dependently promoted the growth of both HepG2 and MHCC97H cells. ISO-induced growth and survival of HCC cells were effectively attenuated by ICI 118551, U0126 and PD153035, but not by H-89 or LY294002. ISO transiently activated MAPK/ERK1/2 in tumor cells which could be blocked either by ICI 118551 or U0126, but not by H-89, LY294002, or PD153035. These findings indicate that ISO mimicking a mitogen promoted the growth of HepG2 and MHCC97H cells via β2-AR-mediated activation of both MAPK/ERK1/2 dependent and independent signaling pathways, and ISO activated MAPK/ERK1/2 by an EGFR-independent mechanism.

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Copy and paste a formatted citation
Spandidos Publications style
Yuan A, Li Z, Li X, Yi S, Wang S, Cai Y and Cao H: The mitogenic effectors of isoproterenol in human hepatocellular carcinoma cells. Oncol Rep 23: 151-157, 2010.
APA
Yuan, A., Li, Z., Li, X., Yi, S., Wang, S., Cai, Y., & Cao, H. (2010). The mitogenic effectors of isoproterenol in human hepatocellular carcinoma cells. Oncology Reports, 23, 151-157. https://doi.org/10.3892/or_00000616
MLA
Yuan, A., Li, Z., Li, X., Yi, S., Wang, S., Cai, Y., Cao, H."The mitogenic effectors of isoproterenol in human hepatocellular carcinoma cells". Oncology Reports 23.1 (2010): 151-157.
Chicago
Yuan, A., Li, Z., Li, X., Yi, S., Wang, S., Cai, Y., Cao, H."The mitogenic effectors of isoproterenol in human hepatocellular carcinoma cells". Oncology Reports 23, no. 1 (2010): 151-157. https://doi.org/10.3892/or_00000616
Copy and paste a formatted citation
x
Spandidos Publications style
Yuan A, Li Z, Li X, Yi S, Wang S, Cai Y and Cao H: The mitogenic effectors of isoproterenol in human hepatocellular carcinoma cells. Oncol Rep 23: 151-157, 2010.
APA
Yuan, A., Li, Z., Li, X., Yi, S., Wang, S., Cai, Y., & Cao, H. (2010). The mitogenic effectors of isoproterenol in human hepatocellular carcinoma cells. Oncology Reports, 23, 151-157. https://doi.org/10.3892/or_00000616
MLA
Yuan, A., Li, Z., Li, X., Yi, S., Wang, S., Cai, Y., Cao, H."The mitogenic effectors of isoproterenol in human hepatocellular carcinoma cells". Oncology Reports 23.1 (2010): 151-157.
Chicago
Yuan, A., Li, Z., Li, X., Yi, S., Wang, S., Cai, Y., Cao, H."The mitogenic effectors of isoproterenol in human hepatocellular carcinoma cells". Oncology Reports 23, no. 1 (2010): 151-157. https://doi.org/10.3892/or_00000616
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