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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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February 2010 Volume 23 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 2010 Volume 23 Issue 2

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Article

Quantitative determination of HER2 expression by confocal microscopy assay in CTCs of breast cancer

  • Authors:
    • Sheng Cao
    • Yang Li
    • Jin Li
    • Chang-Fei Li
    • Wei Zhang
    • Zeng-Qi Yang
    • Song-Dong Meng

  • View Affiliations / Copyright

    Affiliations: College of Veterinary Medicine, Northwest A and F University, Shaanxi 712100, P.R. China
  • Pages: 423-428
    |
    Published online on: February 1, 2010
       https://doi.org/10.3892/or_00000651
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Abstract

HER2 analysis in circulating tumor cells (CTCs) may have clinical significance for HER2-targeted therapy as HER2-positive CTCs and disseminated tumor cells can be detected in patients with HER2-negative primary tumors who currently do not have access to HER2-targeted therapy. In this study, we performed quantitative analysis by confocal microscopy assay for evaluation of HER2 expression in individual tumor cells. HER2 testing by confocal microscopy assay exhibited high concordance with results of real-time PCR, Western blot analysis and FISH analysis. We found that there was a significant positive correlation between HER2 overexpression and gene amplification in individual CTCs, which provided validation of confocal microscopy assay for HER2 expression in CTCs. By using subsets of 10 consecutive cells (bins), we conclude that HER2 expression (3+) in CTCs predicts HER2 overexpression of tumor with high probability in breast cancer patients. These results may provide interpretive guidelines for HER2 status assay in CTCs and raise great opportunities for using CTCs as non-invasive and ‘real-time’ biopsy to examine and monitor the status of tumor markers.

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Copy and paste a formatted citation
Spandidos Publications style
Cao S, Li Y, Li J, Li C, Zhang W, Yang Z and Meng S: Quantitative determination of HER2 expression by confocal microscopy assay in CTCs of breast cancer. Oncol Rep 23: 423-428, 2010.
APA
Cao, S., Li, Y., Li, J., Li, C., Zhang, W., Yang, Z., & Meng, S. (2010). Quantitative determination of HER2 expression by confocal microscopy assay in CTCs of breast cancer. Oncology Reports, 23, 423-428. https://doi.org/10.3892/or_00000651
MLA
Cao, S., Li, Y., Li, J., Li, C., Zhang, W., Yang, Z., Meng, S."Quantitative determination of HER2 expression by confocal microscopy assay in CTCs of breast cancer". Oncology Reports 23.2 (2010): 423-428.
Chicago
Cao, S., Li, Y., Li, J., Li, C., Zhang, W., Yang, Z., Meng, S."Quantitative determination of HER2 expression by confocal microscopy assay in CTCs of breast cancer". Oncology Reports 23, no. 2 (2010): 423-428. https://doi.org/10.3892/or_00000651
Copy and paste a formatted citation
x
Spandidos Publications style
Cao S, Li Y, Li J, Li C, Zhang W, Yang Z and Meng S: Quantitative determination of HER2 expression by confocal microscopy assay in CTCs of breast cancer. Oncol Rep 23: 423-428, 2010.
APA
Cao, S., Li, Y., Li, J., Li, C., Zhang, W., Yang, Z., & Meng, S. (2010). Quantitative determination of HER2 expression by confocal microscopy assay in CTCs of breast cancer. Oncology Reports, 23, 423-428. https://doi.org/10.3892/or_00000651
MLA
Cao, S., Li, Y., Li, J., Li, C., Zhang, W., Yang, Z., Meng, S."Quantitative determination of HER2 expression by confocal microscopy assay in CTCs of breast cancer". Oncology Reports 23.2 (2010): 423-428.
Chicago
Cao, S., Li, Y., Li, J., Li, C., Zhang, W., Yang, Z., Meng, S."Quantitative determination of HER2 expression by confocal microscopy assay in CTCs of breast cancer". Oncology Reports 23, no. 2 (2010): 423-428. https://doi.org/10.3892/or_00000651
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