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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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March 2010 Volume 23 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

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Article

Preparation of a novel adenovirus formulation with artificial envelope of multilayer polymer-coatings: Therapeutic effect on metastatic ovarian cancer

  • Authors:
    • Chieko Yoshihara
    • Katsuyuki Hamada
    • Yoshiyuki Koyama

  • View Affiliations / Copyright

    Affiliations: Department of Human Life Science, Otsuma Women's University Graduate School, Tokyo 102-8357, Japan
  • Pages: 733-738
    |
    Published online on: March 1, 2010
       https://doi.org/10.3892/or_00000691
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Abstract

Layer-by-layer deposition of the ionic polymers onto adenovirus particles afforded the multilayer-coated virus vectors. The infectivity of the virus in the presence of anti-adenovirus antibody increased as the layer number and the viruses with five or six polymer layers allowed relatively high efficiency of reporter gene expression in vitro. Therapeutic effect of the intraperitoneal injection of the oncolytic adenovirus with quintal polymer multilayers on the mice bearing intraperitoneal metastatic ovarian cancer was examined. All the control mice injected with PBS died within 21 days after the tumor inoculation. On the other hand, the mice injected with the multilayer-coated oncolytic virus lived much longer and seven eighths of them lived >60 days without apparent accumulation of ascites. These approaches would open a new way to create a novel, safe and efficient viral gene therapy.

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Copy and paste a formatted citation
Spandidos Publications style
Yoshihara C, Hamada K and Koyama Y: Preparation of a novel adenovirus formulation with artificial envelope of multilayer polymer-coatings: Therapeutic effect on metastatic ovarian cancer. Oncol Rep 23: 733-738, 2010.
APA
Yoshihara, C., Hamada, K., & Koyama, Y. (2010). Preparation of a novel adenovirus formulation with artificial envelope of multilayer polymer-coatings: Therapeutic effect on metastatic ovarian cancer. Oncology Reports, 23, 733-738. https://doi.org/10.3892/or_00000691
MLA
Yoshihara, C., Hamada, K., Koyama, Y."Preparation of a novel adenovirus formulation with artificial envelope of multilayer polymer-coatings: Therapeutic effect on metastatic ovarian cancer". Oncology Reports 23.3 (2010): 733-738.
Chicago
Yoshihara, C., Hamada, K., Koyama, Y."Preparation of a novel adenovirus formulation with artificial envelope of multilayer polymer-coatings: Therapeutic effect on metastatic ovarian cancer". Oncology Reports 23, no. 3 (2010): 733-738. https://doi.org/10.3892/or_00000691
Copy and paste a formatted citation
x
Spandidos Publications style
Yoshihara C, Hamada K and Koyama Y: Preparation of a novel adenovirus formulation with artificial envelope of multilayer polymer-coatings: Therapeutic effect on metastatic ovarian cancer. Oncol Rep 23: 733-738, 2010.
APA
Yoshihara, C., Hamada, K., & Koyama, Y. (2010). Preparation of a novel adenovirus formulation with artificial envelope of multilayer polymer-coatings: Therapeutic effect on metastatic ovarian cancer. Oncology Reports, 23, 733-738. https://doi.org/10.3892/or_00000691
MLA
Yoshihara, C., Hamada, K., Koyama, Y."Preparation of a novel adenovirus formulation with artificial envelope of multilayer polymer-coatings: Therapeutic effect on metastatic ovarian cancer". Oncology Reports 23.3 (2010): 733-738.
Chicago
Yoshihara, C., Hamada, K., Koyama, Y."Preparation of a novel adenovirus formulation with artificial envelope of multilayer polymer-coatings: Therapeutic effect on metastatic ovarian cancer". Oncology Reports 23, no. 3 (2010): 733-738. https://doi.org/10.3892/or_00000691
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