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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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March 2010 Volume 23 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Adhesion of ST6Gal I-mediated human colon cancer cells to fibronectin contributes to cell survival by integrin β1-mediated paxillin and AKT activation

  • Authors:
    • Minyoung Lee
    • Jung-Jin Park
    • Yun-Sil Lee

  • View Affiliations / Copyright

    Affiliations: Division of Radiation Effects, Korea Institute of Radiological and Medical Sciences, Seoul 139-706, Korea
  • Pages: 757-761
    |
    Published online on: March 1, 2010
       https://doi.org/10.3892/or_00000695
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Abstract

We have recently demonstrated that ionizing radiation (IR) of cells increased the expression of β-galactoside α-(2,6)-sialyltransferase (ST6Gal I) and the level of glycoprotein sialylation, especially for the key adhesion molecule integrin β1. In addition, ST6Gal I-mediated sialylation of integrin β1 contributed to cell adhesion-mediated radioresistance in colon cancer cells. In this study, we examined IR-induced cell adhesion to the extracellular matrix and evaluated the role of integrin β1-associated downstream signaling molecules, such as paxillin and AKT. IR exposure and ST6Gal I overexpression increased adhesion of SW480 colon cancer cells to fibronectin and contributed to cell survival through the activation of paxillin and AKT. In contrast, knockdown of ST6Gal I or paxillin reduced the level of radiation-induced cell adhesion and increased the level of cell death. These results suggest that integrin β1 sialylation may play a critical role in promoting adhesion of cancer cells by integrin β1-mediated paxillin and AKT activation.

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Copy and paste a formatted citation
Spandidos Publications style
Lee M, Park J and Lee Y: Adhesion of ST6Gal I-mediated human colon cancer cells to fibronectin contributes to cell survival by integrin β1-mediated paxillin and AKT activation. Oncol Rep 23: 757-761, 2010.
APA
Lee, M., Park, J., & Lee, Y. (2010). Adhesion of ST6Gal I-mediated human colon cancer cells to fibronectin contributes to cell survival by integrin β1-mediated paxillin and AKT activation. Oncology Reports, 23, 757-761. https://doi.org/10.3892/or_00000695
MLA
Lee, M., Park, J., Lee, Y."Adhesion of ST6Gal I-mediated human colon cancer cells to fibronectin contributes to cell survival by integrin β1-mediated paxillin and AKT activation". Oncology Reports 23.3 (2010): 757-761.
Chicago
Lee, M., Park, J., Lee, Y."Adhesion of ST6Gal I-mediated human colon cancer cells to fibronectin contributes to cell survival by integrin β1-mediated paxillin and AKT activation". Oncology Reports 23, no. 3 (2010): 757-761. https://doi.org/10.3892/or_00000695
Copy and paste a formatted citation
x
Spandidos Publications style
Lee M, Park J and Lee Y: Adhesion of ST6Gal I-mediated human colon cancer cells to fibronectin contributes to cell survival by integrin β1-mediated paxillin and AKT activation. Oncol Rep 23: 757-761, 2010.
APA
Lee, M., Park, J., & Lee, Y. (2010). Adhesion of ST6Gal I-mediated human colon cancer cells to fibronectin contributes to cell survival by integrin β1-mediated paxillin and AKT activation. Oncology Reports, 23, 757-761. https://doi.org/10.3892/or_00000695
MLA
Lee, M., Park, J., Lee, Y."Adhesion of ST6Gal I-mediated human colon cancer cells to fibronectin contributes to cell survival by integrin β1-mediated paxillin and AKT activation". Oncology Reports 23.3 (2010): 757-761.
Chicago
Lee, M., Park, J., Lee, Y."Adhesion of ST6Gal I-mediated human colon cancer cells to fibronectin contributes to cell survival by integrin β1-mediated paxillin and AKT activation". Oncology Reports 23, no. 3 (2010): 757-761. https://doi.org/10.3892/or_00000695
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