The angiotensin-converting enzyme 2 in tumor growth and tumor-associated angiogenesis in non-small cell lung cancer

  • Authors:
    • Yun Feng
    • Huanying Wan
    • Jialin Liu
    • Ruifeng Zhang
    • Qinyun Ma
    • Bing Han
    • Yi Xiang
    • Jiaming Che
    • Huangming Cao
    • Xiaochun Fei
    • Weicheng Qiu
  • View Affiliations

  • Published online on: April 1, 2010     https://doi.org/10.3892/or_00000718
  • Pages: 941-948
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Angiotensin II (AngII) is a multifunctional bioactive peptide and previous studies have shown that the renin-angiotensin system (RAS) of both host and tumor are important in tumor growth and angiogenesis in lung cancer. Angiotensin-converting enzyme 2 (ACE2) is a newly identified component of RAS, with 42% amino acid homology to ACE. However, the expression and function of ACE2 in non-small cell lung cancer (NSCLC) are still unclear. In the present study, we analyzed ACE2 expression in NSCLC tissue by Western blot analysis and immunohistochemistry. AngII concentrations in the tissue homogenate were also detected using radio-immunoassay. We also examined the function of ACE2 by transducing A549 cells with MSCV-ACE2. We have shown for the first time that ACE2 expression decreased in NSCLC tissue in which AngII was higher than the matching non-malignant tissues. A concentration of 10−6 mol/l of AngII significantly increased expression of vascular endothelial growth factor a (VEGFa) and AT1-R and decreased ACE2 expression. We also found that overexpression of ACE2 may have a protective effect by inhibiting cell growth and VEGFa production in vitro. ACE2 may become a target of novel strategies to treat NSCLC.

Related Articles

Journal Cover

April 2010
Volume 23 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Feng Y, Wan H, Liu J, Zhang R, Ma Q, Han B, Xiang Y, Che J, Cao H, Fei X, Fei X, et al: The angiotensin-converting enzyme 2 in tumor growth and tumor-associated angiogenesis in non-small cell lung cancer. Oncol Rep 23: 941-948, 2010.
APA
Feng, Y., Wan, H., Liu, J., Zhang, R., Ma, Q., Han, B. ... Qiu, W. (2010). The angiotensin-converting enzyme 2 in tumor growth and tumor-associated angiogenesis in non-small cell lung cancer. Oncology Reports, 23, 941-948. https://doi.org/10.3892/or_00000718
MLA
Feng, Y., Wan, H., Liu, J., Zhang, R., Ma, Q., Han, B., Xiang, Y., Che, J., Cao, H., Fei, X., Qiu, W."The angiotensin-converting enzyme 2 in tumor growth and tumor-associated angiogenesis in non-small cell lung cancer". Oncology Reports 23.4 (2010): 941-948.
Chicago
Feng, Y., Wan, H., Liu, J., Zhang, R., Ma, Q., Han, B., Xiang, Y., Che, J., Cao, H., Fei, X., Qiu, W."The angiotensin-converting enzyme 2 in tumor growth and tumor-associated angiogenesis in non-small cell lung cancer". Oncology Reports 23, no. 4 (2010): 941-948. https://doi.org/10.3892/or_00000718