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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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April 2010 Volume 23 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

The angiotensin-converting enzyme 2 in tumor growth and tumor-associated angiogenesis in non-small cell lung cancer

  • Authors:
    • Yun Feng
    • Huanying Wan
    • Jialin Liu
    • Ruifeng Zhang
    • Qinyun Ma
    • Bing Han
    • Yi Xiang
    • Jiaming Che
    • Huangming Cao
    • Xiaochun Fei
    • Weicheng Qiu

  • View Affiliations / Copyright

    Affiliations: Department of Respiration, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, P.R. China
  • Pages: 941-948
    |
    Published online on: April 1, 2010
       https://doi.org/10.3892/or_00000718
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Abstract

Angiotensin II (AngII) is a multifunctional bioactive peptide and previous studies have shown that the renin-angiotensin system (RAS) of both host and tumor are important in tumor growth and angiogenesis in lung cancer. Angiotensin-converting enzyme 2 (ACE2) is a newly identified component of RAS, with 42% amino acid homology to ACE. However, the expression and function of ACE2 in non-small cell lung cancer (NSCLC) are still unclear. In the present study, we analyzed ACE2 expression in NSCLC tissue by Western blot analysis and immunohistochemistry. AngII concentrations in the tissue homogenate were also detected using radio-immunoassay. We also examined the function of ACE2 by transducing A549 cells with MSCV-ACE2. We have shown for the first time that ACE2 expression decreased in NSCLC tissue in which AngII was higher than the matching non-malignant tissues. A concentration of 10−6 mol/l of AngII significantly increased expression of vascular endothelial growth factor a (VEGFa) and AT1-R and decreased ACE2 expression. We also found that overexpression of ACE2 may have a protective effect by inhibiting cell growth and VEGFa production in vitro. ACE2 may become a target of novel strategies to treat NSCLC.

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Copy and paste a formatted citation
Spandidos Publications style
Feng Y, Wan H, Liu J, Zhang R, Ma Q, Han B, Xiang Y, Che J, Cao H, Fei X, Fei X, et al: The angiotensin-converting enzyme 2 in tumor growth and tumor-associated angiogenesis in non-small cell lung cancer. Oncol Rep 23: 941-948, 2010.
APA
Feng, Y., Wan, H., Liu, J., Zhang, R., Ma, Q., Han, B. ... Qiu, W. (2010). The angiotensin-converting enzyme 2 in tumor growth and tumor-associated angiogenesis in non-small cell lung cancer. Oncology Reports, 23, 941-948. https://doi.org/10.3892/or_00000718
MLA
Feng, Y., Wan, H., Liu, J., Zhang, R., Ma, Q., Han, B., Xiang, Y., Che, J., Cao, H., Fei, X., Qiu, W."The angiotensin-converting enzyme 2 in tumor growth and tumor-associated angiogenesis in non-small cell lung cancer". Oncology Reports 23.4 (2010): 941-948.
Chicago
Feng, Y., Wan, H., Liu, J., Zhang, R., Ma, Q., Han, B., Xiang, Y., Che, J., Cao, H., Fei, X., Qiu, W."The angiotensin-converting enzyme 2 in tumor growth and tumor-associated angiogenesis in non-small cell lung cancer". Oncology Reports 23, no. 4 (2010): 941-948. https://doi.org/10.3892/or_00000718
Copy and paste a formatted citation
x
Spandidos Publications style
Feng Y, Wan H, Liu J, Zhang R, Ma Q, Han B, Xiang Y, Che J, Cao H, Fei X, Fei X, et al: The angiotensin-converting enzyme 2 in tumor growth and tumor-associated angiogenesis in non-small cell lung cancer. Oncol Rep 23: 941-948, 2010.
APA
Feng, Y., Wan, H., Liu, J., Zhang, R., Ma, Q., Han, B. ... Qiu, W. (2010). The angiotensin-converting enzyme 2 in tumor growth and tumor-associated angiogenesis in non-small cell lung cancer. Oncology Reports, 23, 941-948. https://doi.org/10.3892/or_00000718
MLA
Feng, Y., Wan, H., Liu, J., Zhang, R., Ma, Q., Han, B., Xiang, Y., Che, J., Cao, H., Fei, X., Qiu, W."The angiotensin-converting enzyme 2 in tumor growth and tumor-associated angiogenesis in non-small cell lung cancer". Oncology Reports 23.4 (2010): 941-948.
Chicago
Feng, Y., Wan, H., Liu, J., Zhang, R., Ma, Q., Han, B., Xiang, Y., Che, J., Cao, H., Fei, X., Qiu, W."The angiotensin-converting enzyme 2 in tumor growth and tumor-associated angiogenesis in non-small cell lung cancer". Oncology Reports 23, no. 4 (2010): 941-948. https://doi.org/10.3892/or_00000718
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