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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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April 2010 Volume 23 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Inhibitory effects of melatonin on sulfatase and 17β-hydroxysteroid dehydrogenase activity and expression in glioma cells

  • Authors:
    • Alicia González
    • Carlos Martínez-Campa
    • Maria Dolores Mediavilla
    • Carolina Alonso-González
    • Virginia Álvarez-García
    • Emilio José Sánchez-Barceló
    • Samuel Cos

  • View Affiliations / Copyright

    Affiliations: Department of Physiology and Pharmacology, School of Medicine, University of Cantabria, 39011 Santander, Spain
  • Pages: 1173-1178
    |
    Published online on: April 1, 2010
       https://doi.org/10.3892/or_00000748
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Abstract

Melatonin interacts with estradiol at the estrogen receptor level in different kinds of neoplasias and also regulates the expression and the activity of some enzymes involved in the biosynthesis of estrogens in peripheral tissues. Glioma cells express estrogen receptors and have the ability to synthesize estrogens locally. Since melatonin inhibits the growth of C6 cells, and this indoleamine has been demonstrated to be capable of decreasing aromatase expression and activity in these cells, the aim of the present study was to analyze whether the regulation of the sulfatase, the enzyme that catalyzes the rate-limiting step in the conversion of estrogen sulfates to estrogens, and 17β-hydroxysteroid dehydrogenase, the enzyme which converts the relatively inactive estrone to the most potent 17β-estradiol, could be involved in the inhibition of glioma cell growth by melatonin. We found that melatonin decreases the growth of C6 glioma cells and reduces the sulfatase and 17β-hydroxysteroid dehydrogenase activity. Finally, we demonstrated that melatonin downregulates sulfatase and 17β-hydroxysteroid dehydrogenase mRNA steady state levels in these glioma cells. By analogy to the implications of these enzymes in other forms of estrogen-sensitive tumors, it is conceivable that their modulation by melatonin may play a role in the growth of glioblastomas.

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Copy and paste a formatted citation
Spandidos Publications style
González A, Martínez-Campa C, Mediavilla MD, Alonso-González C, Álvarez-García V, Sánchez-Barceló EJ and Cos S: Inhibitory effects of melatonin on sulfatase and 17β-hydroxysteroid dehydrogenase activity and expression in glioma cells. Oncol Rep 23: 1173-1178, 2010.
APA
González, A., Martínez-Campa, C., Mediavilla, M.D., Alonso-González, C., Álvarez-García, V., Sánchez-Barceló, E.J., & Cos, S. (2010). Inhibitory effects of melatonin on sulfatase and 17β-hydroxysteroid dehydrogenase activity and expression in glioma cells. Oncology Reports, 23, 1173-1178. https://doi.org/10.3892/or_00000748
MLA
González, A., Martínez-Campa, C., Mediavilla, M. D., Alonso-González, C., Álvarez-García, V., Sánchez-Barceló, E. J., Cos, S."Inhibitory effects of melatonin on sulfatase and 17β-hydroxysteroid dehydrogenase activity and expression in glioma cells". Oncology Reports 23.4 (2010): 1173-1178.
Chicago
González, A., Martínez-Campa, C., Mediavilla, M. D., Alonso-González, C., Álvarez-García, V., Sánchez-Barceló, E. J., Cos, S."Inhibitory effects of melatonin on sulfatase and 17β-hydroxysteroid dehydrogenase activity and expression in glioma cells". Oncology Reports 23, no. 4 (2010): 1173-1178. https://doi.org/10.3892/or_00000748
Copy and paste a formatted citation
x
Spandidos Publications style
González A, Martínez-Campa C, Mediavilla MD, Alonso-González C, Álvarez-García V, Sánchez-Barceló EJ and Cos S: Inhibitory effects of melatonin on sulfatase and 17β-hydroxysteroid dehydrogenase activity and expression in glioma cells. Oncol Rep 23: 1173-1178, 2010.
APA
González, A., Martínez-Campa, C., Mediavilla, M.D., Alonso-González, C., Álvarez-García, V., Sánchez-Barceló, E.J., & Cos, S. (2010). Inhibitory effects of melatonin on sulfatase and 17β-hydroxysteroid dehydrogenase activity and expression in glioma cells. Oncology Reports, 23, 1173-1178. https://doi.org/10.3892/or_00000748
MLA
González, A., Martínez-Campa, C., Mediavilla, M. D., Alonso-González, C., Álvarez-García, V., Sánchez-Barceló, E. J., Cos, S."Inhibitory effects of melatonin on sulfatase and 17β-hydroxysteroid dehydrogenase activity and expression in glioma cells". Oncology Reports 23.4 (2010): 1173-1178.
Chicago
González, A., Martínez-Campa, C., Mediavilla, M. D., Alonso-González, C., Álvarez-García, V., Sánchez-Barceló, E. J., Cos, S."Inhibitory effects of melatonin on sulfatase and 17β-hydroxysteroid dehydrogenase activity and expression in glioma cells". Oncology Reports 23, no. 4 (2010): 1173-1178. https://doi.org/10.3892/or_00000748
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