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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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May 2010 Volume 23 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Pre-radiation enhances the cytotoxicity of docetaxel in head and neck squamous cell carcinoma cells

  • Authors:
    • Satori Furuse
    • Makoto Adachi
    • Kei Ijichi
    • Shinsuke Ohta
    • Soichiro Torigoe
    • Masatoshi Nakazawa
    • Satoshi Miura
    • Kenji Mitsudo
    • Iwai Tohnai

  • View Affiliations / Copyright

    Affiliations: Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan
  • Pages: 1339-1343
    |
    Published online on: May 1, 2010
       https://doi.org/10.3892/or_00000769
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Abstract

This study was designed to determine the effect of the treatment schedule on the interaction between docetaxel and irradiation. Human head and neck squamous cell carcinoma (HNSCC) cells with different p53 status, and HSC4 (p53 wild-type) and CAL27 (p53 mutant type) cells were treated with docetaxel and irradiation using three schedules: i) concurrent treatment, ii) docetaxel pretreatment and iii) pre-radiation. Docetaxel and radiation inhibited the proliferation of HSC4 and CAL27 cells in a dose-dependent manner. However, irradiation pretreatment was more effective than the other treatment regimens in all cells. Our data suggest that pre-radiation in HNSCC cells significantly enhances docetaxel cytotoxity by arresting S-phase, and this provides the most effective treatment sequence of docetaxel and radiation combination therapy. Therefore, radiation followed by docetaxel may be the most effective sequence for head and neck cancer therapy.

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Copy and paste a formatted citation
Spandidos Publications style
Furuse S, Adachi M, Ijichi K, Ohta S, Torigoe S, Nakazawa M, Miura S, Mitsudo K and Tohnai I: Pre-radiation enhances the cytotoxicity of docetaxel in head and neck squamous cell carcinoma cells . Oncol Rep 23: 1339-1343, 2010.
APA
Furuse, S., Adachi, M., Ijichi, K., Ohta, S., Torigoe, S., Nakazawa, M. ... Tohnai, I. (2010). Pre-radiation enhances the cytotoxicity of docetaxel in head and neck squamous cell carcinoma cells . Oncology Reports, 23, 1339-1343. https://doi.org/10.3892/or_00000769
MLA
Furuse, S., Adachi, M., Ijichi, K., Ohta, S., Torigoe, S., Nakazawa, M., Miura, S., Mitsudo, K., Tohnai, I."Pre-radiation enhances the cytotoxicity of docetaxel in head and neck squamous cell carcinoma cells ". Oncology Reports 23.5 (2010): 1339-1343.
Chicago
Furuse, S., Adachi, M., Ijichi, K., Ohta, S., Torigoe, S., Nakazawa, M., Miura, S., Mitsudo, K., Tohnai, I."Pre-radiation enhances the cytotoxicity of docetaxel in head and neck squamous cell carcinoma cells ". Oncology Reports 23, no. 5 (2010): 1339-1343. https://doi.org/10.3892/or_00000769
Copy and paste a formatted citation
x
Spandidos Publications style
Furuse S, Adachi M, Ijichi K, Ohta S, Torigoe S, Nakazawa M, Miura S, Mitsudo K and Tohnai I: Pre-radiation enhances the cytotoxicity of docetaxel in head and neck squamous cell carcinoma cells . Oncol Rep 23: 1339-1343, 2010.
APA
Furuse, S., Adachi, M., Ijichi, K., Ohta, S., Torigoe, S., Nakazawa, M. ... Tohnai, I. (2010). Pre-radiation enhances the cytotoxicity of docetaxel in head and neck squamous cell carcinoma cells . Oncology Reports, 23, 1339-1343. https://doi.org/10.3892/or_00000769
MLA
Furuse, S., Adachi, M., Ijichi, K., Ohta, S., Torigoe, S., Nakazawa, M., Miura, S., Mitsudo, K., Tohnai, I."Pre-radiation enhances the cytotoxicity of docetaxel in head and neck squamous cell carcinoma cells ". Oncology Reports 23.5 (2010): 1339-1343.
Chicago
Furuse, S., Adachi, M., Ijichi, K., Ohta, S., Torigoe, S., Nakazawa, M., Miura, S., Mitsudo, K., Tohnai, I."Pre-radiation enhances the cytotoxicity of docetaxel in head and neck squamous cell carcinoma cells ". Oncology Reports 23, no. 5 (2010): 1339-1343. https://doi.org/10.3892/or_00000769
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