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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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May 2010 Volume 23 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

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Article

The enhanced transcriptional activity of the V-val subtype of Epstein-Barr virus nuclear antigen 1 in epithelial cell lines

  • Authors:
    • Shi-Juan Mai
    • Dan Xie
    • Yu-Fan Huang
    • Feng-Wei Wang
    • Yi-Ji Liao
    • Hai-Xia Deng
    • Wen-Ju Liu
    • Wen-Feng Hua
    • Yi-Xin Zeng

  • View Affiliations / Copyright

    Affiliations: Department of Experimental Research, State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat-sen University, Guangzhou 510060, P.R. China
  • Pages: 1417-1424
    |
    Published online on: May 1, 2010
       https://doi.org/10.3892/or_00000779
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Abstract

The Epstein-Barr virus encoded nuclear antigen 1 (EBNA1) is required for the replication and maintenance of the episomal EBV genome and for the transactivation of viral gene expression. EBNA1 has been classified into five subtypes, among which the V-val subtype was reported to be associated with nasopharyngeal carcinoma (NPC). Here we report a higher transcriptional activity of the V-val subtype of EBNA1 than for the prototype derived from B95.8 cells to transactivate FR-containing luciferase plasmid, which was mainly a consequence of the mutations in the carboxy-terminus of EBNA1. This interpretation was further supported by the finding that the variant form of EBNA1 has a higher binding affinity for the FR sequence than the prototype by electrophoretic mobility shift assays. The functional advantage of the V-val EBNA1 investigated in this study may contribute to the oncogenesis of NPC.

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Copy and paste a formatted citation
Spandidos Publications style
Mai S, Xie D, Huang Y, Wang F, Liao Y, Deng H, Liu W, Hua W and Zeng Y: The enhanced transcriptional activity of the V-val subtype of Epstein-Barr virus nuclear antigen 1 in epithelial cell lines . Oncol Rep 23: 1417-1424, 2010.
APA
Mai, S., Xie, D., Huang, Y., Wang, F., Liao, Y., Deng, H. ... Zeng, Y. (2010). The enhanced transcriptional activity of the V-val subtype of Epstein-Barr virus nuclear antigen 1 in epithelial cell lines . Oncology Reports, 23, 1417-1424. https://doi.org/10.3892/or_00000779
MLA
Mai, S., Xie, D., Huang, Y., Wang, F., Liao, Y., Deng, H., Liu, W., Hua, W., Zeng, Y."The enhanced transcriptional activity of the V-val subtype of Epstein-Barr virus nuclear antigen 1 in epithelial cell lines ". Oncology Reports 23.5 (2010): 1417-1424.
Chicago
Mai, S., Xie, D., Huang, Y., Wang, F., Liao, Y., Deng, H., Liu, W., Hua, W., Zeng, Y."The enhanced transcriptional activity of the V-val subtype of Epstein-Barr virus nuclear antigen 1 in epithelial cell lines ". Oncology Reports 23, no. 5 (2010): 1417-1424. https://doi.org/10.3892/or_00000779
Copy and paste a formatted citation
x
Spandidos Publications style
Mai S, Xie D, Huang Y, Wang F, Liao Y, Deng H, Liu W, Hua W and Zeng Y: The enhanced transcriptional activity of the V-val subtype of Epstein-Barr virus nuclear antigen 1 in epithelial cell lines . Oncol Rep 23: 1417-1424, 2010.
APA
Mai, S., Xie, D., Huang, Y., Wang, F., Liao, Y., Deng, H. ... Zeng, Y. (2010). The enhanced transcriptional activity of the V-val subtype of Epstein-Barr virus nuclear antigen 1 in epithelial cell lines . Oncology Reports, 23, 1417-1424. https://doi.org/10.3892/or_00000779
MLA
Mai, S., Xie, D., Huang, Y., Wang, F., Liao, Y., Deng, H., Liu, W., Hua, W., Zeng, Y."The enhanced transcriptional activity of the V-val subtype of Epstein-Barr virus nuclear antigen 1 in epithelial cell lines ". Oncology Reports 23.5 (2010): 1417-1424.
Chicago
Mai, S., Xie, D., Huang, Y., Wang, F., Liao, Y., Deng, H., Liu, W., Hua, W., Zeng, Y."The enhanced transcriptional activity of the V-val subtype of Epstein-Barr virus nuclear antigen 1 in epithelial cell lines ". Oncology Reports 23, no. 5 (2010): 1417-1424. https://doi.org/10.3892/or_00000779
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