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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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June 2010 Volume 23 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Histological features of extratumoral breast lesions as a predictive factor of familial breast cancer

  • Authors:
    • Anita Mangia
    • Stefania Tommasi
    • Michele Bruno
    • Andrea Malfettone
    • Cosimo D'Amico
    • Francesco Alfredo Zito
    • Angelo Paradiso
    • Giovanni Simone

  • View Affiliations / Copyright

    Affiliations: Clinical Experimental Oncology Laboratory, National Cancer Institute, 70126 Bari, Italy. a.mangia@oncologico.bari.it
  • Pages: 1641-1645
    |
    Published online on: June 1, 2010
       https://doi.org/10.3892/or_00000806
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Abstract

The aim of this study was to verify whether histopathological features of extratumoral and of primary tumor breast tissue could play a role in identifying patients with familial characteristics. We examined the clinicopathological features of 504 patients with sporadic or familial breast cancer stratified for risk of BRCA mutation. Patients with a higher risk of being carrier of BRCA gene mutations were significantly associated with tumor poor differentiation (p=0.003), positive lymph node invasion (p=0.02) and presence of vascular peritumoral invasion (p=0.008). Among the extra-tumoral lesions, only the epithelial proliferative lesions were related to higher mutation risk both in the overall series and familial patients (p<0.0001 and p=0.003, respectively). Interestingly, a significant difference in terms of high mutation risk was observed in usual ductal hyperplasia lesions (UDH), (p=0.002). We suggest that vascular peritumoral invasion and UDH lesions could predict a higher mutation risk of BRCA1 and BRCA2 genes and help in individuating patient candidates to further molecular analysis.

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Copy and paste a formatted citation
Spandidos Publications style
Mangia A, Tommasi S, Bruno M, Malfettone A, D'Amico C, Zito FA, Paradiso A and Simone G: Histological features of extratumoral breast lesions as a predictive factor of familial breast cancer . Oncol Rep 23: 1641-1645, 2010.
APA
Mangia, A., Tommasi, S., Bruno, M., Malfettone, A., D'Amico, C., Zito, F.A. ... Simone, G. (2010). Histological features of extratumoral breast lesions as a predictive factor of familial breast cancer . Oncology Reports, 23, 1641-1645. https://doi.org/10.3892/or_00000806
MLA
Mangia, A., Tommasi, S., Bruno, M., Malfettone, A., D'Amico, C., Zito, F. A., Paradiso, A., Simone, G."Histological features of extratumoral breast lesions as a predictive factor of familial breast cancer ". Oncology Reports 23.6 (2010): 1641-1645.
Chicago
Mangia, A., Tommasi, S., Bruno, M., Malfettone, A., D'Amico, C., Zito, F. A., Paradiso, A., Simone, G."Histological features of extratumoral breast lesions as a predictive factor of familial breast cancer ". Oncology Reports 23, no. 6 (2010): 1641-1645. https://doi.org/10.3892/or_00000806
Copy and paste a formatted citation
x
Spandidos Publications style
Mangia A, Tommasi S, Bruno M, Malfettone A, D'Amico C, Zito FA, Paradiso A and Simone G: Histological features of extratumoral breast lesions as a predictive factor of familial breast cancer . Oncol Rep 23: 1641-1645, 2010.
APA
Mangia, A., Tommasi, S., Bruno, M., Malfettone, A., D'Amico, C., Zito, F.A. ... Simone, G. (2010). Histological features of extratumoral breast lesions as a predictive factor of familial breast cancer . Oncology Reports, 23, 1641-1645. https://doi.org/10.3892/or_00000806
MLA
Mangia, A., Tommasi, S., Bruno, M., Malfettone, A., D'Amico, C., Zito, F. A., Paradiso, A., Simone, G."Histological features of extratumoral breast lesions as a predictive factor of familial breast cancer ". Oncology Reports 23.6 (2010): 1641-1645.
Chicago
Mangia, A., Tommasi, S., Bruno, M., Malfettone, A., D'Amico, C., Zito, F. A., Paradiso, A., Simone, G."Histological features of extratumoral breast lesions as a predictive factor of familial breast cancer ". Oncology Reports 23, no. 6 (2010): 1641-1645. https://doi.org/10.3892/or_00000806
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