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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July 2010 Volume 24 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Immunohistochemial evaluation of sarcoglycans and integrins in gingival epithelium of multiple myeloma patients with bisphosphonate-induced osteonecrosis of the jaw

  • Authors:
    • Enrico Nastro Siniscalchi
    • Giuseppina Cutroneo
    • Luciano Catalfamo
    • Giuseppe Santoro
    • Alessandro Allegra
    • Giacomo Oteri
    • Domenico Cicciù
    • Andrea Alonci
    • Giuseppa Penna
    • Caterina Musolino
    • Francesco Saverio De Ponte
    • Giuseppe Anastasi
    • Angelo Favaloro

  • View Affiliations / Copyright

    Affiliations: Division of Maxillofacial Surgery, University of Messina, Messina, Italy
  • Pages: 129-134
    |
    Published online on: July 1, 2010
       https://doi.org/10.3892/or_00000837
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Abstract

Osteonecrosis of the jaw (ONJ) is an adverse outcome associated to bisphosphonate treatment. However, it is not known whether the ONJ lesion originates in the bone, or whether it may initiate in the oral mucosa. The aim of our study was to evaluate the pattern of basal lamina of oral mucosa after bisphosphonate administration and to analyze the structural damage of the mucosa in ONJ patients, and in subjects treated with bisphosphonates without osteonecrosis. By immunohistochemistry, we evaluated changes in basement membrane by expression of signalling proteins, laminin, and type IV collagen. All tested proteins were almost absent in basal lamina and mucosa of subjects treated with bisphosphonates without osteonecrosis, whereas in mucosa of patients with ONJ, they showed a clearly detectable pattern of the same proteins, specifically in basal lamina, but less in comparison to control samples. Moreover, in pathological mucosa, the clearly detectable staining pattern for VEGF indicated a massive neoangiogenesis. Bisphosphonates induce changes in expression of proteins also in oral mucosa. The increase of these proteins in basal lamina, and the neo-angiogenesis, concomitant with formation of the lesion, could indicate a compensative behaviour in the remodelling of the gingival mucosa in order to restore the epithelial architecture.

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Copy and paste a formatted citation
Spandidos Publications style
Nastro Siniscalchi E, Cutroneo G, Catalfamo L, Santoro G, Allegra A, Oteri G, Cicciù D, Alonci A, Penna G, Musolino C, Musolino C, et al: Immunohistochemial evaluation of sarcoglycans and integrins in gingival epithelium of multiple myeloma patients with bisphosphonate-induced osteonecrosis of the jaw . Oncol Rep 24: 129-134, 2010.
APA
Nastro Siniscalchi, E., Cutroneo, G., Catalfamo, L., Santoro, G., Allegra, A., Oteri, G. ... Favaloro, A. (2010). Immunohistochemial evaluation of sarcoglycans and integrins in gingival epithelium of multiple myeloma patients with bisphosphonate-induced osteonecrosis of the jaw . Oncology Reports, 24, 129-134. https://doi.org/10.3892/or_00000837
MLA
Nastro Siniscalchi, E., Cutroneo, G., Catalfamo, L., Santoro, G., Allegra, A., Oteri, G., Cicciù, D., Alonci, A., Penna, G., Musolino, C., Saverio De Ponte, F., Anastasi, G., Favaloro, A."Immunohistochemial evaluation of sarcoglycans and integrins in gingival epithelium of multiple myeloma patients with bisphosphonate-induced osteonecrosis of the jaw ". Oncology Reports 24.1 (2010): 129-134.
Chicago
Nastro Siniscalchi, E., Cutroneo, G., Catalfamo, L., Santoro, G., Allegra, A., Oteri, G., Cicciù, D., Alonci, A., Penna, G., Musolino, C., Saverio De Ponte, F., Anastasi, G., Favaloro, A."Immunohistochemial evaluation of sarcoglycans and integrins in gingival epithelium of multiple myeloma patients with bisphosphonate-induced osteonecrosis of the jaw ". Oncology Reports 24, no. 1 (2010): 129-134. https://doi.org/10.3892/or_00000837
Copy and paste a formatted citation
x
Spandidos Publications style
Nastro Siniscalchi E, Cutroneo G, Catalfamo L, Santoro G, Allegra A, Oteri G, Cicciù D, Alonci A, Penna G, Musolino C, Musolino C, et al: Immunohistochemial evaluation of sarcoglycans and integrins in gingival epithelium of multiple myeloma patients with bisphosphonate-induced osteonecrosis of the jaw . Oncol Rep 24: 129-134, 2010.
APA
Nastro Siniscalchi, E., Cutroneo, G., Catalfamo, L., Santoro, G., Allegra, A., Oteri, G. ... Favaloro, A. (2010). Immunohistochemial evaluation of sarcoglycans and integrins in gingival epithelium of multiple myeloma patients with bisphosphonate-induced osteonecrosis of the jaw . Oncology Reports, 24, 129-134. https://doi.org/10.3892/or_00000837
MLA
Nastro Siniscalchi, E., Cutroneo, G., Catalfamo, L., Santoro, G., Allegra, A., Oteri, G., Cicciù, D., Alonci, A., Penna, G., Musolino, C., Saverio De Ponte, F., Anastasi, G., Favaloro, A."Immunohistochemial evaluation of sarcoglycans and integrins in gingival epithelium of multiple myeloma patients with bisphosphonate-induced osteonecrosis of the jaw ". Oncology Reports 24.1 (2010): 129-134.
Chicago
Nastro Siniscalchi, E., Cutroneo, G., Catalfamo, L., Santoro, G., Allegra, A., Oteri, G., Cicciù, D., Alonci, A., Penna, G., Musolino, C., Saverio De Ponte, F., Anastasi, G., Favaloro, A."Immunohistochemial evaluation of sarcoglycans and integrins in gingival epithelium of multiple myeloma patients with bisphosphonate-induced osteonecrosis of the jaw ". Oncology Reports 24, no. 1 (2010): 129-134. https://doi.org/10.3892/or_00000837
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