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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July 2010 Volume 24 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2010 Volume 24 Issue 1

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Article

HSG provides antitumor efficacy on hepatocellular carcinoma both in vitro and in vivo

  • Authors:
    • Weilin Wang
    • Feng Zhu
    • Shuqian Wang
    • Jianfeng Wei
    • Changku Jia
    • Yuanbiao Zhang
    • Lin Zhou
    • Haiyang Xie
    • Shusen Zheng

  • View Affiliations / Copyright

    Affiliations: Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health, Key Laboratory of Organ Transplantation, Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, P.R. China
  • Pages: 183-188
    |
    Published online on: July 1, 2010
       https://doi.org/10.3892/or_00000844
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Abstract

Hyperplasia suppressor gene (HSG) is a novel gene that markedly suppresses the mitogenetic stimuli or injury mediated by vascular smooth muscle cell proliferation. Herein we provide experimental evidence to show that HSG can also play a key role in tumor proliferation. Down-regulation of HSG protein in hepatocellular carcinoma tissues compared to adjacent tissues. Overexpression of HSG suppressed the growth of liver cancer cell lines, resulted in cell cycle arrest in the G0/G1 phase, increased expression of the cyclin dependent kinase inhibitors (CKIs), and reduced expression of proliferating cell nuclear antigen (PCNA). It also showed that adenovirus-mediated HSG overexpression induced apoptosis. Up-regulation of HSG by adenovirus also significantly suppressed the growth of subcutaneous tumors in nude mice both ex vivo and in vivo. Collectively, our data suggest that HSG is a potential therapy for tumors and possibly other proliferative diseases as well and it has antitumor efficacy on hepatocellular carcinoma by using adenovirus vectors, which may be a new therapeutic target for liver cancer prevention.

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Copy and paste a formatted citation
Spandidos Publications style
Wang W, Zhu F, Wang S, Wei J, Jia C, Zhang Y, Zhou L, Xie H and Zheng S: HSG provides antitumor efficacy on hepatocellular carcinoma both in vitro and in vivo. Oncol Rep 24: 183-188, 2010.
APA
Wang, W., Zhu, F., Wang, S., Wei, J., Jia, C., Zhang, Y. ... Zheng, S. (2010). HSG provides antitumor efficacy on hepatocellular carcinoma both in vitro and in vivo. Oncology Reports, 24, 183-188. https://doi.org/10.3892/or_00000844
MLA
Wang, W., Zhu, F., Wang, S., Wei, J., Jia, C., Zhang, Y., Zhou, L., Xie, H., Zheng, S."HSG provides antitumor efficacy on hepatocellular carcinoma both in vitro and in vivo". Oncology Reports 24.1 (2010): 183-188.
Chicago
Wang, W., Zhu, F., Wang, S., Wei, J., Jia, C., Zhang, Y., Zhou, L., Xie, H., Zheng, S."HSG provides antitumor efficacy on hepatocellular carcinoma both in vitro and in vivo". Oncology Reports 24, no. 1 (2010): 183-188. https://doi.org/10.3892/or_00000844
Copy and paste a formatted citation
x
Spandidos Publications style
Wang W, Zhu F, Wang S, Wei J, Jia C, Zhang Y, Zhou L, Xie H and Zheng S: HSG provides antitumor efficacy on hepatocellular carcinoma both in vitro and in vivo. Oncol Rep 24: 183-188, 2010.
APA
Wang, W., Zhu, F., Wang, S., Wei, J., Jia, C., Zhang, Y. ... Zheng, S. (2010). HSG provides antitumor efficacy on hepatocellular carcinoma both in vitro and in vivo. Oncology Reports, 24, 183-188. https://doi.org/10.3892/or_00000844
MLA
Wang, W., Zhu, F., Wang, S., Wei, J., Jia, C., Zhang, Y., Zhou, L., Xie, H., Zheng, S."HSG provides antitumor efficacy on hepatocellular carcinoma both in vitro and in vivo". Oncology Reports 24.1 (2010): 183-188.
Chicago
Wang, W., Zhu, F., Wang, S., Wei, J., Jia, C., Zhang, Y., Zhou, L., Xie, H., Zheng, S."HSG provides antitumor efficacy on hepatocellular carcinoma both in vitro and in vivo". Oncology Reports 24, no. 1 (2010): 183-188. https://doi.org/10.3892/or_00000844
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