c-Met antisense oligodeoxynucleotides increase sensitivity of human glioma cells to paclitaxel

  • Authors:
    • Sheng-Hua Chu
    • Yan-Bin Ma
    • Dong-Fu Feng
    • Hong Zhang
    • Jian-Hua Qiu
    • Zhi-An Zhu
  • View Affiliations

  • Published online on: July 1, 2010     https://doi.org/10.3892/or_00000845
  • Pages: 189-194
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Cell culture, tissue chemistry and flow cytometry were used to determine whether antisense c-Met oligodeoxynucleotides enhanced the sensitivity of human glioma cells to paclitaxel. A combination of paclitaxel with antisense c-Met oligodeoxynucleotides inhibited cell growth, induced apoptosis and induced c-Met protein expression in U251 and SHG44 human glioma cells more significantly than either paclitaxel or the oligodeoxynucleotides on their own (P<0.01). Thus, c-Met antisense oligodeoxynucleotides increase the sensitivity of human glioma cells to paclitaxel. Combined use of the two agents could be a novel and attractive strategy in human glioma treatment.

Related Articles

Journal Cover

July 2010
Volume 24 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Chu S, Ma Y, Feng D, Zhang H, Qiu J and Zhu Z: c-Met antisense oligodeoxynucleotides increase sensitivity of human glioma cells to paclitaxel. Oncol Rep 24: 189-194, 2010
APA
Chu, S., Ma, Y., Feng, D., Zhang, H., Qiu, J., & Zhu, Z. (2010). c-Met antisense oligodeoxynucleotides increase sensitivity of human glioma cells to paclitaxel. Oncology Reports, 24, 189-194. https://doi.org/10.3892/or_00000845
MLA
Chu, S., Ma, Y., Feng, D., Zhang, H., Qiu, J., Zhu, Z."c-Met antisense oligodeoxynucleotides increase sensitivity of human glioma cells to paclitaxel". Oncology Reports 24.1 (2010): 189-194.
Chicago
Chu, S., Ma, Y., Feng, D., Zhang, H., Qiu, J., Zhu, Z."c-Met antisense oligodeoxynucleotides increase sensitivity of human glioma cells to paclitaxel". Oncology Reports 24, no. 1 (2010): 189-194. https://doi.org/10.3892/or_00000845