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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July 2010 Volume 24 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

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Article

Down-regulated expression of SERPIN genes located on chromosome 18q21 in oral squamous cell carcinomas

  • Authors:
    • Masashi Shiiba
    • Hitomi Nomura
    • Keiji Shinozuka
    • Kengo Saito
    • Yukinao Kouzu
    • Atsushi Kasamatsu
    • Yosuke Sakamoto
    • Akiyuki Murano
    • Kanae Ono
    • Katsunori Ogawara
    • Katsuhiro Uzawa
    • Hideki Tanzawa

  • View Affiliations / Copyright

    Affiliations: Department of Clinical Molecular Biology, Graduate School of Medicine, Chiba University, Chiba city, Chiba 260-8670, Japan. m.shiiba@faculty.chiba-u.jp
  • Pages: 241-249
    |
    Published online on: July 1, 2010
       https://doi.org/10.3892/or_00000852
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Abstract

Serpins (serine protease inhibitors) are known as a diverse family of protease inhibitors; however, various other biological activities including tumor suppression, have been recently reported for these molecules. To clarify whether members of the serpin family are involved in OSCC (oral squamous cell carcinoma), global gene screening using microarray analysis was performed with OSCC-derived cell lines. A trend toward diminished expression was shown for some SERPIN genes located on 11q12-q13.1 and 18q21. mRNA expression of SERPIN genes at these chromosome regions was therefore analyzed using real-time quantitative RT-PCR (qRT-PCR) in 55 OSCC samples and matched normal tissue. Statistically significant decreases in expression were found for SERPINB12 (P=0.001), SERPINB13 (P=0.001), SERPINB4 (P=0.042), SERPINB3 (P<0.001), SERPINB11 (P<0.001), SERPINB7 (P=0.021) and SERPINB2 (P=0.018). All of these genes are located on 18q21, the known location of the serpin gene cluster. The results strongly suggest that this chromosome region plays a crucial role in OSCC. Some serpin members in the region might be involved in tumor suppression, or there might be unidentified tumor suppressor genes within or near the chromosome region.

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Copy and paste a formatted citation
Spandidos Publications style
Shiiba M, Nomura H, Shinozuka K, Saito K, Kouzu Y, Kasamatsu A, Sakamoto Y, Murano A, Ono K, Ogawara K, Ogawara K, et al: Down-regulated expression of SERPIN genes located on chromosome 18q21 in oral squamous cell carcinomas . Oncol Rep 24: 241-249, 2010.
APA
Shiiba, M., Nomura, H., Shinozuka, K., Saito, K., Kouzu, Y., Kasamatsu, A. ... Tanzawa, H. (2010). Down-regulated expression of SERPIN genes located on chromosome 18q21 in oral squamous cell carcinomas . Oncology Reports, 24, 241-249. https://doi.org/10.3892/or_00000852
MLA
Shiiba, M., Nomura, H., Shinozuka, K., Saito, K., Kouzu, Y., Kasamatsu, A., Sakamoto, Y., Murano, A., Ono, K., Ogawara, K., Uzawa, K., Tanzawa, H."Down-regulated expression of SERPIN genes located on chromosome 18q21 in oral squamous cell carcinomas ". Oncology Reports 24.1 (2010): 241-249.
Chicago
Shiiba, M., Nomura, H., Shinozuka, K., Saito, K., Kouzu, Y., Kasamatsu, A., Sakamoto, Y., Murano, A., Ono, K., Ogawara, K., Uzawa, K., Tanzawa, H."Down-regulated expression of SERPIN genes located on chromosome 18q21 in oral squamous cell carcinomas ". Oncology Reports 24, no. 1 (2010): 241-249. https://doi.org/10.3892/or_00000852
Copy and paste a formatted citation
x
Spandidos Publications style
Shiiba M, Nomura H, Shinozuka K, Saito K, Kouzu Y, Kasamatsu A, Sakamoto Y, Murano A, Ono K, Ogawara K, Ogawara K, et al: Down-regulated expression of SERPIN genes located on chromosome 18q21 in oral squamous cell carcinomas . Oncol Rep 24: 241-249, 2010.
APA
Shiiba, M., Nomura, H., Shinozuka, K., Saito, K., Kouzu, Y., Kasamatsu, A. ... Tanzawa, H. (2010). Down-regulated expression of SERPIN genes located on chromosome 18q21 in oral squamous cell carcinomas . Oncology Reports, 24, 241-249. https://doi.org/10.3892/or_00000852
MLA
Shiiba, M., Nomura, H., Shinozuka, K., Saito, K., Kouzu, Y., Kasamatsu, A., Sakamoto, Y., Murano, A., Ono, K., Ogawara, K., Uzawa, K., Tanzawa, H."Down-regulated expression of SERPIN genes located on chromosome 18q21 in oral squamous cell carcinomas ". Oncology Reports 24.1 (2010): 241-249.
Chicago
Shiiba, M., Nomura, H., Shinozuka, K., Saito, K., Kouzu, Y., Kasamatsu, A., Sakamoto, Y., Murano, A., Ono, K., Ogawara, K., Uzawa, K., Tanzawa, H."Down-regulated expression of SERPIN genes located on chromosome 18q21 in oral squamous cell carcinomas ". Oncology Reports 24, no. 1 (2010): 241-249. https://doi.org/10.3892/or_00000852
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