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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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September 2010 Volume 24 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 2010 Volume 24 Issue 3

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Article

Mechanisms of the antitumor action of the new antibiotic NC0604, a member of the bleomycin family

  • Authors:
    • Weiwei Shi
    • Caixia Chen
    • Xiumin Zhang
    • Hongzhang Xu
    • Ruxian Chen
    • Qiyang He

  • View Affiliations / Copyright

    Affiliations: Institute of Medicinal Biotechnology, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, P.R. China
  • Pages: 629-635
    |
    Published online on: September 1, 2010
       https://doi.org/10.3892/or_00000901
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Abstract

NC0604, the new antibiotic of the bleomycin family, was isolated from the fermentation broth of Streptomyces verticillus var. pingyangensis n.sp. In this study, we investigated its mechanisms of antitumor action in vitro and in vivo. The results showed that the colony formation inhibition of NC0604 was 2-10 times higher than that of bleomycin to several tumor cell types. In comparison to bleomycin, a better antitumor efficacy of NC0604 was observed in the BALB/c mice loading mouse hepatoma H22 tumors. Flow cytometry assay detected an increase of intracellular reactive oxygen species and arrest at G2/M phase in human hepatoma HepG2 cells after exposure to NC0604. The comet of DNA damage was also observed in the NC0604-treated cells using single cell gel electrophoresis assay. The chromatin condensation appeared in the NC0604-induced apoptotic cells. The activation of apoptotic caspase pathway and increase of apoptosis-modulated protein expression, such as p53, Bax, were also detected by Western blot analysis. Taken together, the anti-tumor actions of NC0604 involve activation of the apoptotic pathway and it is valuable for further drug development.

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Copy and paste a formatted citation
Spandidos Publications style
Shi W, Chen C, Zhang X, Xu H, Chen R and He Q: Mechanisms of the antitumor action of the new antibiotic NC0604, a member of the bleomycin family . Oncol Rep 24: 629-635, 2010.
APA
Shi, W., Chen, C., Zhang, X., Xu, H., Chen, R., & He, Q. (2010). Mechanisms of the antitumor action of the new antibiotic NC0604, a member of the bleomycin family . Oncology Reports, 24, 629-635. https://doi.org/10.3892/or_00000901
MLA
Shi, W., Chen, C., Zhang, X., Xu, H., Chen, R., He, Q."Mechanisms of the antitumor action of the new antibiotic NC0604, a member of the bleomycin family ". Oncology Reports 24.3 (2010): 629-635.
Chicago
Shi, W., Chen, C., Zhang, X., Xu, H., Chen, R., He, Q."Mechanisms of the antitumor action of the new antibiotic NC0604, a member of the bleomycin family ". Oncology Reports 24, no. 3 (2010): 629-635. https://doi.org/10.3892/or_00000901
Copy and paste a formatted citation
x
Spandidos Publications style
Shi W, Chen C, Zhang X, Xu H, Chen R and He Q: Mechanisms of the antitumor action of the new antibiotic NC0604, a member of the bleomycin family . Oncol Rep 24: 629-635, 2010.
APA
Shi, W., Chen, C., Zhang, X., Xu, H., Chen, R., & He, Q. (2010). Mechanisms of the antitumor action of the new antibiotic NC0604, a member of the bleomycin family . Oncology Reports, 24, 629-635. https://doi.org/10.3892/or_00000901
MLA
Shi, W., Chen, C., Zhang, X., Xu, H., Chen, R., He, Q."Mechanisms of the antitumor action of the new antibiotic NC0604, a member of the bleomycin family ". Oncology Reports 24.3 (2010): 629-635.
Chicago
Shi, W., Chen, C., Zhang, X., Xu, H., Chen, R., He, Q."Mechanisms of the antitumor action of the new antibiotic NC0604, a member of the bleomycin family ". Oncology Reports 24, no. 3 (2010): 629-635. https://doi.org/10.3892/or_00000901
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