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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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September 2010 Volume 24 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 2010 Volume 24 Issue 3

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Article

Down-regulation of fractalkine inhibits the in vitro and in vivo angiogenesis of the hepatocellular carcinoma HepG2 cells

  • Authors:
    • Feng Li
    • Zuoren Wang
    • Yongcun Liu
    • Junhui Li

  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary Surgery, the First Affiliated Hospital of Medical College, Xi'an Jiao Tong University, Xi'an 710061, Shaanxi Province, P.R. China
  • Pages: 669-675
    |
    Published online on: September 1, 2010
       https://doi.org/10.3892/or_00000906
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Abstract

There is increasing evidence that hepatocellular carcinoma (HCC) is inherently associated with the inflammatory process and the up-regulation of cytokines. Our study aimed at elucidating the role of the cytokine fractalkine in the process of HCC carcinogenesis. Expression of fractalkine in hepatocellular carcinoma cell line HepG2 was knocked-down by RNAi. Conditioned media (CMs) from HepG2 was used in angiogenesis assays both in vitro and in vivo. Compared with CMs from mock transfection and negative shRNA treated HepG2, CMs from fractalkine shRNA treated HepG2 highly suppressed the migration, proliferation, and differentiation of human umbilical vein endothelial cells. The results suggest that fractalkine may play a key role in the mechanism of angiogenesis and carcinogenesis of HCC.

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Copy and paste a formatted citation
Spandidos Publications style
Li F, Wang Z, Liu Y and Li J: Down-regulation of fractalkine inhibits the in vitro and in vivo angiogenesis of the hepatocellular carcinoma HepG2 cells . Oncol Rep 24: 669-675, 2010.
APA
Li, F., Wang, Z., Liu, Y., & Li, J. (2010). Down-regulation of fractalkine inhibits the in vitro and in vivo angiogenesis of the hepatocellular carcinoma HepG2 cells . Oncology Reports, 24, 669-675. https://doi.org/10.3892/or_00000906
MLA
Li, F., Wang, Z., Liu, Y., Li, J."Down-regulation of fractalkine inhibits the in vitro and in vivo angiogenesis of the hepatocellular carcinoma HepG2 cells ". Oncology Reports 24.3 (2010): 669-675.
Chicago
Li, F., Wang, Z., Liu, Y., Li, J."Down-regulation of fractalkine inhibits the in vitro and in vivo angiogenesis of the hepatocellular carcinoma HepG2 cells ". Oncology Reports 24, no. 3 (2010): 669-675. https://doi.org/10.3892/or_00000906
Copy and paste a formatted citation
x
Spandidos Publications style
Li F, Wang Z, Liu Y and Li J: Down-regulation of fractalkine inhibits the in vitro and in vivo angiogenesis of the hepatocellular carcinoma HepG2 cells . Oncol Rep 24: 669-675, 2010.
APA
Li, F., Wang, Z., Liu, Y., & Li, J. (2010). Down-regulation of fractalkine inhibits the in vitro and in vivo angiogenesis of the hepatocellular carcinoma HepG2 cells . Oncology Reports, 24, 669-675. https://doi.org/10.3892/or_00000906
MLA
Li, F., Wang, Z., Liu, Y., Li, J."Down-regulation of fractalkine inhibits the in vitro and in vivo angiogenesis of the hepatocellular carcinoma HepG2 cells ". Oncology Reports 24.3 (2010): 669-675.
Chicago
Li, F., Wang, Z., Liu, Y., Li, J."Down-regulation of fractalkine inhibits the in vitro and in vivo angiogenesis of the hepatocellular carcinoma HepG2 cells ". Oncology Reports 24, no. 3 (2010): 669-675. https://doi.org/10.3892/or_00000906
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