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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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September 2010 Volume 24 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 2010 Volume 24 Issue 3

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Article

FBXO31 is down-regulated and may function as a tumor suppressor in hepatocellular carcinoma

  • Authors:
    • Hai-Li Huang
    • Wen-Ling Zheng
    • Rui Zhao
    • Bao Zhang
    • Wen-Li Ma

  • View Affiliations / Copyright

    Affiliations: Institute of Molecular Biology, Southern Medical University, Guangzhou 510515, P.R. China
  • Pages: 715-720
    |
    Published online on: September 1, 2010
       https://doi.org/10.3892/or_00000912
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Abstract

The F-box protein family member FBXO31 has rarely been studied in human hepatocellular carcinoma (HCC). This study was designed to investigate the expression profile of FBXO31 in HCC and the possibility that FBXO31 might function as a tumor suppressor in HCC cell lines. We report that FBXO31 is strongly down-regulated in HCC cell lines and specimens. Ectopic expression of FBXO31 inhibited cell proliferation and colony formation in HepG2 and Hep3B cells. The endogenous expression of FBXO31 was fluctuated through cell cycle in the HepG2 cells with maximal expression from late G2 to early G1 phase. Ectopic expression of FBXO31 in HepG2 resulted in the accumulation of cells at the G1 phase of the cell cycle. Possible mechanism might be cyclin D1 degradation mediate by FBXO31 through ubiquitin ligase pathway. Ectopic overexpression of FBXO31 resulted in down-regulation of cyclin D1 which leads to the accumulation of cells at the G1 phase of the cell cycle. Cytoplasmic location of FBXO31 was consistent with cyclin D1 degradation in cytoplasm. Together, our findings suggested that down-regulation of FBXO31 might function as a tumor suppressor in HCC.

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Copy and paste a formatted citation
Spandidos Publications style
Huang H, Zheng W, Zhao R, Zhang B and Ma W: FBXO31 is down-regulated and may function as a tumor suppressor in hepatocellular carcinoma . Oncol Rep 24: 715-720, 2010.
APA
Huang, H., Zheng, W., Zhao, R., Zhang, B., & Ma, W. (2010). FBXO31 is down-regulated and may function as a tumor suppressor in hepatocellular carcinoma . Oncology Reports, 24, 715-720. https://doi.org/10.3892/or_00000912
MLA
Huang, H., Zheng, W., Zhao, R., Zhang, B., Ma, W."FBXO31 is down-regulated and may function as a tumor suppressor in hepatocellular carcinoma ". Oncology Reports 24.3 (2010): 715-720.
Chicago
Huang, H., Zheng, W., Zhao, R., Zhang, B., Ma, W."FBXO31 is down-regulated and may function as a tumor suppressor in hepatocellular carcinoma ". Oncology Reports 24, no. 3 (2010): 715-720. https://doi.org/10.3892/or_00000912
Copy and paste a formatted citation
x
Spandidos Publications style
Huang H, Zheng W, Zhao R, Zhang B and Ma W: FBXO31 is down-regulated and may function as a tumor suppressor in hepatocellular carcinoma . Oncol Rep 24: 715-720, 2010.
APA
Huang, H., Zheng, W., Zhao, R., Zhang, B., & Ma, W. (2010). FBXO31 is down-regulated and may function as a tumor suppressor in hepatocellular carcinoma . Oncology Reports, 24, 715-720. https://doi.org/10.3892/or_00000912
MLA
Huang, H., Zheng, W., Zhao, R., Zhang, B., Ma, W."FBXO31 is down-regulated and may function as a tumor suppressor in hepatocellular carcinoma ". Oncology Reports 24.3 (2010): 715-720.
Chicago
Huang, H., Zheng, W., Zhao, R., Zhang, B., Ma, W."FBXO31 is down-regulated and may function as a tumor suppressor in hepatocellular carcinoma ". Oncology Reports 24, no. 3 (2010): 715-720. https://doi.org/10.3892/or_00000912
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