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Pathotropic targeting advances clinical oncology: Tumor-targeted localization of therapeutic gene delivery

  • Authors:
    • Frederick L. Hall
    • John P. Levy
    • Rebecca A. Reed
    • Wasinee N. Petchpud
    • Victoria S. Chua
    • Sant P. Chawla
    • Erlinda M. Gordon

  • View Affiliations

  • Published online on: October 1, 2010     https://doi.org/10.3892/or_00000926
  • Pages: 829-833
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Abstract

The advent of pathotropic (disease-seeking) targeting has transported genetic medicine across the threshold of history with the progressive clinical validation of Rexin-G, a tumor-targeted nanosized anti-cancer agent. Achieving noteworthy single-agent efficacy and survival benefits in otherwise intractable cancers, the molecular biotechnology platform has stimulated intense interest in the underlying mechanisms-of-action. This report exhibits the effective localization of Rexin-G nanoparticles within a metastatic liver lesion, as observed upon its surgical excision.

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Journal Cover

October 2010
Volume 24 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Journal Metrics
  • Impact Factor: 4.2
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 8.4
  • CiteScore Rank: Q1: #68/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.786
  • SCImago Journal Rank (SJR): 0.812
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Spandidos Publications style
Hall FL, Levy JP, Reed RA, Petchpud WN, Chua VS, Chawla SP and Gordon EM: Pathotropic targeting advances clinical oncology: Tumor-targeted localization of therapeutic gene delivery . Oncol Rep 24: 829-833, 2010
APA
Hall, F.L., Levy, J.P., Reed, R.A., Petchpud, W.N., Chua, V.S., Chawla, S.P., & Gordon, E.M. (2010). Pathotropic targeting advances clinical oncology: Tumor-targeted localization of therapeutic gene delivery . Oncology Reports, 24, 829-833. https://doi.org/10.3892/or_00000926
MLA
Hall, F. L., Levy, J. P., Reed, R. A., Petchpud, W. N., Chua, V. S., Chawla, S. P., Gordon, E. M."Pathotropic targeting advances clinical oncology: Tumor-targeted localization of therapeutic gene delivery ". Oncology Reports 24.4 (2010): 829-833.
Chicago
Hall, F. L., Levy, J. P., Reed, R. A., Petchpud, W. N., Chua, V. S., Chawla, S. P., Gordon, E. M."Pathotropic targeting advances clinical oncology: Tumor-targeted localization of therapeutic gene delivery ". Oncology Reports 24, no. 4 (2010): 829-833. https://doi.org/10.3892/or_00000926