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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
October 2010 Volume 24 Issue 4

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Article

Nutrition in oncology: the case of micronutrients (Review)

Alexander Ströhle, Kurt Zänker, Andreas Hahn
Pages: 815-828
Published online on: 01 October 2010

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Article Open Access

Pathotropic targeting advances clinical oncology: Tumor-targeted localization of therapeutic gene delivery

Frederick L. Hall, John P. Levy, Rebecca A. Reed, Wasinee N. Petchpud, Victoria S. Chua, Sant P. Chawla, Erlinda M. Gordon
Pages: 829-833
Published online on: 01 October 2010

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Article

Irinotecan overcomes the resistance to 5-fluorouracil in human colon cancer xenografts by down-regulation of intratumoral thymidylate synthase

Masakazu Fukushima, Kazuki Sakamoto, Hideyuki Ohshimo, Fumio Nakagawa, Tetsuo Taguchi
Pages: 835-842
Published online on: 01 October 2010

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Article Open Access

Anti-tumor effect by inhibition of NF-κB activation using nafamostat mesilate for pancreatic cancer in a mouse model

Kenei Furukawa, Tomonori Iida, Hiroaki Shiba, Yuki Fujiwara, Tadashi Uwagawa, Yohta Shimada, Takeyuki Misawa, Toya Ohashi, Katsuhiko Yanaga
Pages: 843-850
Published online on: 01 October 2010

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Article

p53 mutation, but not in vitro predictor genes of therapeutic efficacy of cisplatin, is clinically relevant in comparing partial and complete responder cases of maxillary squamous cell carcinoma

Itsuhiro Kudo, Mariko Esumi, Akihiro Kida, Minoru Ikeda
Pages: 851-856
Published online on: 01 October 2010

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Article

A new approach to concordance in mid-infrared spectromicroscopy mapping of malignant tumors

Kaiser Ali, Todd Reichert, Daniel Gomez, Yanjie Lu, Alexander Jan, Colleen Christensen
Pages: 857-860
Published online on: 01 October 2010

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Article

CD98 expression is associated with the grade of malignancy in thymic epithelial tumors

Kyoichi Kaira, Toshiaki Takahashi, Masato Abe, Hiroaki Akamatsu, Kazuo Nakagawa, Yasuhisa Ohde, Takehiro Okumura, Haruyasu Murakami, Asuka Tsuya, Yukiko Nakamura, Tateaki Naito, Haruhiko Kondo, Takashi Nakajima, Masahiro Endo, Nobuyuki Yamamoto
Pages: 861-867
Published online on: 01 October 2010

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Article

Increased apoptosis and decreased proliferation of colonic epithelium in dextran sulfate sodium-induced colitis in mice

Yoshio Araki, Ken-Ichi Mukaisyo, Hiroyuki Sugihara, Yoshihide Fujiyama, Takanori Hattori
Pages: 869-874
Published online on: 01 October 2010

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Article

DNA copy number aberrations associated with aneuploidy and chromosomal instability in breast cancers

Shigeto Kawauchi, Tomoko Furuya, Kenzo Ikemoto, Motonao Nakao, Shigeru Yamamoto, Masaaki Oka, Kohsuke Sasaki
Pages: 875-883
Published online on: 01 October 2010

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Article

Genetic profiles distinguish different types of hereditary ovarian cancer

Katarina Domanska, Susanne Malander, Johan Staaf, Anna Karlsson, Åke Borg, Göran Jönsson, Mef Nilbert
Pages: 885-895
Published online on: 01 October 2010

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Article

High-level transgene expression mediated by the piggyBac transposon enhances transgenic therapeutic effects in cervical cancer xenografts

Yu Kang, Wenbo Yu, Qinwen Sun, Xiaoyan Zhang, Wei Jiang, Chaoqun Wu, Chunmei Chen, Jianren Gu, Yufang Zheng, Congjian Xu
Pages: 897-907
Published online on: 01 October 2010

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Article

Elevated L1CAM expression in precursor lesions and primary and metastastic tissues of pancreatic ductal adenocarcinoma

Frank Bergmann, Frauke Wandschneider, Bence Sipos, Gerhard Moldenhauer, Bodo Schniewind, Thilo Welsch, Peter Schirrmacher, Günter Klöppel, Peter Altevogt, Heiner Schäfer, Susanne Sebens Müerköster
Pages: 909-915
Published online on: 01 October 2010

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Article

High-throughput DNA hypermethylation profiling in different ovarian epithelial cancer subtypes using universal bead array

Man Soo Yoon, Dong Soo Suh, Kyung Un Choi, Mee Young Sol, Dong Hoon Shin, Won Young Park, Jung Hee Lee, Seong Muk Jeong, Woo Gyeong Kim, Na Ri Shin
Pages: 917-925
Published online on: 01 October 2010

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Article

Microsatellite instability and hMLH1 and hMSH2 expression in renal tumors

Giuseppe Altavilla, Matteo Fassan, Graziella Busatto, Martina Orsolan, Luciano Giacomelli
Pages: 927-932
Published online on: 01 October 2010

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Article

C4orf7 contributes to ovarian cancer metastasis by promoting cancer cell migration and invasion

Changyu Wang, Li Zhou, Shuang Li, Juncheng Wei, Wei Wang, Ting Zhou, Shujie Liao, Danhui Weng, Dongrui Deng, Yanjie Weng, Shixuan Wang, Ding Ma
Pages: 933-939
Published online on: 01 October 2010

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Article

The antitumor and antimetastatic effects of N-trimethyl chitosan-encapsulated camptothecin on ovarian cancer with minimal side effects

Lina Zhou, Licheng Du, Xiancheng Chen, Xingyi Li, Zhiyong Li, Yuan Wen, Zhengyu Li, Xiang He, Yuquan Wei, Xia Zhao, Zhiyong Qian
Pages: 941-948
Published online on: 01 October 2010

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Article

14-3-3σ expression as a prognostic marker in undifferentiated nasopharyngeal carcinoma

Sylvia Yat-Yee Chan, Ka-Fai To, Sing-Fai Leung, William Wai-Lun Yip, Michael Ko-Fung Mak, Grace Tin-Yun Chung, Kwok-Wai Lo
Pages: 949-955
Published online on: 01 October 2010

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Article

Deguelin promotes apoptosis and inhibits angiogenesis of gastric cancer

Hyunseung Lee, Ju-Hee Lee, Kyung Hee Jung, Soon-Sun Hong
Pages: 957-963
Published online on: 01 October 2010

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Article

Role for ezrin in breast cancer cell chemotaxis to CCL5

Juanjuan Li, Yi Tu, Jing Wen, Feng Yao, Wen Wei, Shengrong Sun
Pages: 965-971
Published online on: 01 October 2010

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Article

Thermoseed hyperthermia treatment of mammary orthotopic transplantation tumors in rats and impact on immune function

Weiwei Ouyang, Fuping Gao, Lufang Wang, Xiaoxue Xie, Fenglin Lei, Jumei Zhou, Yuping Liao, Meizuo Zhong, Jintian Tang
Pages: 973-979
Published online on: 01 October 2010

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Article

SATB1 is an independent prognostic marker for gastric cancer in a Chinese population

Xiaoming Lu, Chao Cheng, Shikai Zhu, Yun Yang, Liduan Zheng, Guobin Wang, Xiaogang Shu, Ke Wu, Ke Liu, Qiang Tong
Pages: 981-987
Published online on: 01 October 2010

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Article

The chemokine receptor 7 regulates cell adhesion and migration via β1 integrin in metastatic squamous cell carcinoma of the head and neck

Peng Li, Zhen-Jin Zhao, Fa-Yu Liu, Li-Yan Sun, Xue Ding, Wen-Zhong Zhang, De-Hao Shang, Chang-Fu Sun
Pages: 989-995
Published online on: 01 October 2010

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Article

A pivotal role for Pim-1 kinase in esophageal squamous cell carcinoma involving cell apoptosis induced by reducing Akt phosphorylation

Shenglei Li, Yu Xi, Hongyan Zhang, Yange Wang, Xin Wang, Hongtao Liu, Kuisheng Chen
Pages: 997-1004
Published online on: 01 October 2010

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Article

RhoA protein is generally distributed in the nuclei of cancer cells

Yueying Li, Yongchang Chen, Yan Tao, Jin Xu, Miao Chen
Pages: 1005-1009
Published online on: 01 October 2010

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Article Open Access

Acquired resistance to miriplatin in rat hepatoma AH109A/MP10 is associated with increased Bcl-2 expression, leading to defects in inducing apoptosis

Mitsuharu Hanada, Hideo Takasu, Makoto Kitaura
Pages: 1011-1018
Published online on: 01 October 2010

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Article

VEGFR and EGFR inhibition increases epithelial cellular characteristics and chemotherapy sensitivity in mesenchymal bladder cancer cells

Yuan Li, Xiaoping Yang, Lih-Jen Su, Thomas W. Flaig
Pages: 1019-1028
Published online on: 01 October 2010

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Article

Possibility of paclitaxel as an alternative radiosensitizer to 5-fluorouracil for colon cancer

Junichiro Hiro, Yasuhiro Inoue, Yuji Toiyama, Shigeyuki Yoshiyama, Koji Tanaka, Yasuhiko Mohri, Chikao Miki, Masato Kusunoki
Pages: 1029-1034
Published online on: 01 October 2010

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Article

WNT pathway in oral cancer: Epigenetic inactivation of WNT-inhibitors

G. Pannone, P. Bufo, A. Santoro, R. Franco, G. Aquino, F. Longo, G. Botti, R. Serpico, B. Cafarelli, A. Abbruzzese, M. Caraglia, S. Papagerakis, L. Lo Muzio
Pages: 1035-1041
Published online on: 01 October 2010

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Article

Up-regulation of NKG2F receptor, a functionally unknown killer receptor, of human natural killer cells by interleukin-2 and interleukin-15

Haihua Huang, Xin Wang, Yukun Zhang, Xiaodong Zheng, Haiming Wei, Rui Sun
Pages: 1043-1048
Published online on: 01 October 2010

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Article

Sorafenib enhances the in vitro anti-endothelial effects of low dose (metronomic) chemotherapy

Alexandra Murray, Samantha J. Little, Paul Stanley, Anthony Maraveyas, Lynn Cawkwell
Pages: 1049-1058
Published online on: 01 October 2010

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Article

Inhibition of tankyrase 1 in human gastric cancer cells enhances telomere shortening by telomerase inhibitors

Hao Zhang, Meng-Hua Yang, Jing-Jing Zhao, Ling Chen, Song-Tao Yu, Xu-Dong Tang, Dian-Chun Fang, Shi-Ming Yang
Pages: 1059-1065
Published online on: 01 October 2010

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Article

Establishment of a rhabdomyosarcoma xenograft model in human-adapted mice

Guido Seitz, Matthias Pfeiffer, Jörg Fuchs, Steven W. Warmann, Ivo Leuschner, Christian Vokuhl, Peter Lang, Rupert Handgretinger, Sorin Armeanu-Ebinger
Pages: 1067-1072
Published online on: 01 October 2010

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Article

Association between metalloproteinases 2 and 9 activity and ERK1/2 phosphorylation status in head and neck cancers: An ex vivo study

Werner Garavello, Daniele Maggioni, Gabriella Nicolini, Lorenzo Motta, Giovanni Tredici, Renato Gaini
Pages: 1073-1078
Published online on: 01 October 2010

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Article

The role of common variants of non-homologous end-joining repair genes XRCC4, LIG4 and Ku80 in thyroid cancer risk

Bruno Costa Gomes, Susana Nunes Silva, Ana Paula Azevedo, Isabel Manita, Octávia Monteiro Gil, Teresa Cruz Ferreira, Edward Limbert, José Rueff, Jorge Francisco Gaspar
Pages: 1079-1085
Published online on: 01 October 2010

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Article

Pomegranate extract inhibits the proliferation and viability of MMTV-Wnt-1 mouse mammary cancer stem cells in vitro

Zhaoli Dai, Vidhya Nair, Maruf Khan, Henry P. Ciolino
Pages: 1087-1091
Published online on: 01 October 2010

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Article

β-catenin siRNA regulation of apoptosis- and angiogenesis-related gene expression in hepatocellular carcinoma cells: potential uses for gene therapy

Xin-Hong Wang, Xun Sun, Xiang-Wei Meng, Zhi-Wu Lv, Ya-Ju Du, Yan Zhu, Jing Chen, De-Xia Kong, Shi-Zhu Jin
Pages: 1093-1099
Published online on: 01 October 2010

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Article

Predictive significance of the cut-off value of CD20 expression in patients with B-cell lymphoma

Mateja Horvat, Veronika Kloboves Prevodnik, Jaka Lavrencak, Barbara Jezersek Novakovic
Pages: 1101-1107
Published online on: 01 October 2010

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Journal Cover
February-2026 Volume 55 Issue 2

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Article Open Access

Exploring the role of disulfidptosis‑related signatures in immune microenvironment, prognosis and therapeutic strategies of cholangiocarcinoma

Yue Chen, Jun Wu, Danxia Zhu, Lu Jiang, Jian Wang, Dachuan Zhang, Wenting He
Article Number: 37
Published online on: 02 January 2026

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Correction Open Access

[Corrigendum] Isolinderalactone enhances the inhibition of SOCS3 on STAT3 activity by decreasing miR‑30c in breast cancer

Meng-Chi Yen, Ying-Chu Shih, Ya-Ling Hsu, En-Shyh Lin, Yi-Shiuan Lin, Eing-Mei Tsai, Ya-Wen Ho, Ming-Feng Hou, Po-Lin Kuo
Article Number: 36
Published online on: 22 December 2025

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Hypoxia‑mediated Krebs von den Lungen‑6 expression in breast cancer: Implications for tumor invasion and metastasis

Taisei Ichihara, Yoshihiro Hayashi, Takuya Sato, Mitsuko Iguchi, Makoto Toi, Hironaga Satake, Ichiro Murakami
Article Number: 35
Published online on: 19 December 2025

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Retraction Open Access

[Retracted] β‑elemene decreases cell invasion by upregulating E‑cadherin expression in MCF‑7 human breast cancer cells

Xian Zhang, Yang Zhang, Yinghua Li
Article Number: 34
Published online on: 18 December 2025

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Review Open Access

Research progress on the regulation of ferroptosis in NPC (Review)

Shuai Bai, Yanjie Guo, Jingling Qiang, Qiangfang Dai, Yanling Yang
Article Number: 33
Published online on: 18 December 2025

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Retraction Open Access

[Retracted] Platelet‑derived growth factor BB mediates the glioma‑induced migration of bone marrow‑derived mesenchymal stem cells by promoting the expression of vascular cell adhesion molecule‑1 through the PI3K, P38 MAPK and NF‑κB pathways

Yi Hu, Peng Cheng, Jiang-Chun Ma, Yi-Xue Xue, Yun-Hui Liu
Article Number: 32
Published online on: 08 December 2025

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Review Open Access

Alternative splicing in cancer drug resistance: Mechanisms and therapeutic prospects (Review)

Wenpu Zhu, Zikun Wu, Chai Luv, Banghe Bao, Weijie Zhao, Guanglong Chen, Hang Yang, Huihan Ai, Faqiang Liu, Zhi Li
Article Number: 31
Published online on: 05 December 2025

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Article Open Access

Inhibition of primary ciliogenesis enhances efficacy of EGFR‑TKIs against non‑small cell lung cancer cells

Liangliang Jin, Li Wei, Junrui Hua, Rong Zhang, Jiaxin Chen, Jinpeng He, Yanli Yang
Article Number: 30
Published online on: 04 December 2025

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Review

Beyond eradication: Therapeutic reprogramming strategies for cancer normalization (Review)

Aliasgar Shahiwala
Article Number: 29
Published online on: 04 December 2025

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Article Open Access

Saikosaponin D overcomes gemcitabine resistance in pancreatic cancer via AKT/mTOR pathway inhibition and synergistic induction of apoptosis and autophagy

Rui Zheng, Yusi Liu, Sen Zhou, Guimei Liu, Xiaobin Liu, Yiyuan Yang, Yufu Zhang
Article Number: 28
Published online on: 04 December 2025

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Retraction Open Access

[Retracted] Downregulation of Bmi‑1 is associated with suppressed tumorigenesis and induced apoptosis in CD44+ nasopharyngeal carcinoma cancer stem‑like cells

Xinhua Xu, Yang Liu, Jin Su, Daojun Li, Juan Hu, Qiao Huang, Mingqian Lu, Xiaoyan Liu, Jinghua Ren, Weihong Chen, Lidan Sun
Article Number: 27
Published online on: 04 December 2025

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Article Open Access

Prognostic significance of fibroblast senescence and senescence-associated secretory phenotype factor expression in the tumor microenvironment of pancreatic ductal adenocarcinoma

Yuto Kitano, Tomoharu Miyashita, Takeo Shimasaki, Isamu Makino, Yoshio Endo, Yasuhiko Yamamoto, Noriyuki Inaki, Shintaro Yagi
Article Number: 26
Published online on: 03 December 2025

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Retraction Open Access

[Retracted] Sp1‑CD147 positive feedback loop promotes the invasion ability of ovarian cancer

Jing Zhao, Wei Ye, Juan Wu, Lijuan Liu, Lina Yang, Lu Gao, Biliang Chen, Fanglin Zhang, Hong Yang, Yu Li
Article Number: 25
Published online on: 25 November 2025

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Journal Cover
March-2026 Volume 55 Issue 3

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Article Open Access

GPR176 enhances the epithelial‑mesenchymal transition in gastric cancer cells by activating the PI3K/AKT/mTOR signaling pathway

Guangchuan Mu, Kaiyan Li, Chaozhen Hu, Jintao Cai, Huichao Ruan, Guanyu Zhu, Dang Liu
Article Number: 48
Published online on: 19 January 2026

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Article Open Access

HMBOX1 inhibits hepatocellular carcinoma progression via PTPN1 mediated AKT1 phosphorylation

Chenning Zhang, Yu Jiang, Jiahui Liu, Wenyu Zhang, Jie Qi, Qing Wen, Hengli Zhao
Article Number: 47
Published online on: 19 January 2026

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Retraction Open Access

[Retracted] Prognostic significance of miR‑218 in human hepatocellular carcinoma and its role in cell growth

Kangsheng Tu, Chao Li, Xin Zheng, Wei Yang, Yingmin Yao, Qingguang Liu
Article Number: 46
Published online on: 19 January 2026

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Review Open Access

Tumor microenvironment in bone sarcomas: Implications for immunotherapy and emerging therapeutic vulnerabilities (Review)

Wentao Li, Lijun Lv, Yibin Jin, Xin Yuan
Article Number: 45
Published online on: 16 January 2026

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Review Open Access

Immunotherapy after EGFR‑TKI treatment in advanced non‑small cell lung cancer: Current status and future perspectives (Review)

Huiyuan Ma, Longhui Li, Conghan Jiao, Yanyan Cheng, Jiayu He, Chen Jiang, Qian Tong, Dan Yi, Ying Zhang
Article Number: 44
Published online on: 16 January 2026

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Correction Open Access

[Corrigendum] Triptolide inhibits JAK2/STAT3 signaling and induces lethal autophagy through ROS generation in cisplatin‑resistant SKOV3/DDP ovarian cancer cells

Yanying Zhong, Fuyin Le, Jiao Cheng, Chen Luo, Xiali Zhang, Xingwu Wu, Fang Xu, Qi Zuo, Buzhen Tan
Article Number: 43
Published online on: 13 January 2026

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Role of tumor‑infiltrating lymphocytes and miR‑155 in breast cancer: Insights into carcinogenesis and their potential as prognostic biomarkers (Review)

Miriam Monteiro Alvares‑Vilela, Franciele Schlemmer, Sabrina Simplício De Araújo Romero Ferrari, Mary-Ann Elvina Xavier, Ricardo Titze‑De‑Almeida
Article Number: 42
Published online on: 14 January 2026

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CDK1 depletion suppresses glioma malignancy through cell cycle pathway regulation: Mechanistic insights from functional and molecular profiling

Yu Wang, Huandi Zhou, Xuetao Han, Dongdong Zhang, Liubing Hou, Haonan Li, Tianyi Fan, Sijie Li, Xiaoying Xue
Article Number: 41
Published online on: 12 January 2026

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Retraction Open Access

[Retracted] Downregulated microRNA‑200a promotes EMT and tumor growth through the Wnt/β‑catenin pathway by targeting the E‑cadherin repressors ZEB1/ZEB2 in gastric adenocarcinoma

Ningning Cong, Ping Du, Anling Zhang, Fajuan Shen, Juan Su, Peiyu Pu, Tao Wang, Jie Zjang, Chunsheng Kang, Qingyu Zhang
Article Number: 40
Published online on: 12 January 2026

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Review Open Access

Advances in targeting KRAS mutations: A promising approach for the treatment of non‑small cell lung cancer (Review)

Upesh Sharma, Jincheng Song, Hemraj Kandu, Yue Zhu, Zhaoxia Dai
Article Number: 39
Published online on: 08 January 2026

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Correction Open Access

[Corrigendum] CXCR6 predicts poor prognosis in gastric cancer and promotes tumor metastasis through epithelial-mesenchymal transition

Jie-Jie Jin, Fa-Xiang Dai, Zi-Wen Long, Hong Cai, Xiao-Wen Liu, Ye Zhou, Qi Hong, Qiong-Zhu Dong, Ya-Nong Wang, Hua Huang
Article Number: 38
Published online on: 05 January 2026

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