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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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October 2010 Volume 24 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 2010 Volume 24 Issue 4

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Article

C4orf7 contributes to ovarian cancer metastasis by promoting cancer cell migration and invasion

  • Authors:
    • Changyu Wang
    • Li Zhou
    • Shuang Li
    • Juncheng Wei
    • Wei Wang
    • Ting Zhou
    • Shujie Liao
    • Danhui Weng
    • Dongrui Deng
    • Yanjie Weng
    • Shixuan Wang
    • Ding Ma

  • View Affiliations / Copyright

    Affiliations: Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China
  • Pages: 933-939
    |
    Published online on: October 1, 2010
       https://doi.org/10.3892/or_00000939
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Abstract

Gene C4orf7, renamed FDC-SP (follicular dendritic cell secreted protein, FDC-SP) was first isolated from human tonsils. Up to the present, the function of this gene was still poorly understood. In this study, we report the expression of gene C4orf7 in a panel of tumor types. The percentages of C4orf7 positive expression in the tumor patients with metastases were notably higher than those in the cancer without metastases. On the contrary, the expression was hardly noted in normal tissues and corresponding benign lesions. In vitro, the up-regulation of C4orf7 in ovarian cancer cell lines was associated with enhanced motility and invasiveness. Furthermore, the overexpression of C4orf7 resulted in Akt ser473 phosphorylation and decreased E-cadherin expression. The role of C4orf7 in ovarian cancer cell morphology, motility and invasion was demonstrated.

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Copy and paste a formatted citation
Spandidos Publications style
Wang C, Zhou L, Li S, Wei J, Wang W, Zhou T, Liao S, Weng D, Deng D, Weng Y, Weng Y, et al: C4orf7 contributes to ovarian cancer metastasis by promoting cancer cell migration and invasion . Oncol Rep 24: 933-939, 2010.
APA
Wang, C., Zhou, L., Li, S., Wei, J., Wang, W., Zhou, T. ... Ma, D. (2010). C4orf7 contributes to ovarian cancer metastasis by promoting cancer cell migration and invasion . Oncology Reports, 24, 933-939. https://doi.org/10.3892/or_00000939
MLA
Wang, C., Zhou, L., Li, S., Wei, J., Wang, W., Zhou, T., Liao, S., Weng, D., Deng, D., Weng, Y., Wang, S., Ma, D."C4orf7 contributes to ovarian cancer metastasis by promoting cancer cell migration and invasion ". Oncology Reports 24.4 (2010): 933-939.
Chicago
Wang, C., Zhou, L., Li, S., Wei, J., Wang, W., Zhou, T., Liao, S., Weng, D., Deng, D., Weng, Y., Wang, S., Ma, D."C4orf7 contributes to ovarian cancer metastasis by promoting cancer cell migration and invasion ". Oncology Reports 24, no. 4 (2010): 933-939. https://doi.org/10.3892/or_00000939
Copy and paste a formatted citation
x
Spandidos Publications style
Wang C, Zhou L, Li S, Wei J, Wang W, Zhou T, Liao S, Weng D, Deng D, Weng Y, Weng Y, et al: C4orf7 contributes to ovarian cancer metastasis by promoting cancer cell migration and invasion . Oncol Rep 24: 933-939, 2010.
APA
Wang, C., Zhou, L., Li, S., Wei, J., Wang, W., Zhou, T. ... Ma, D. (2010). C4orf7 contributes to ovarian cancer metastasis by promoting cancer cell migration and invasion . Oncology Reports, 24, 933-939. https://doi.org/10.3892/or_00000939
MLA
Wang, C., Zhou, L., Li, S., Wei, J., Wang, W., Zhou, T., Liao, S., Weng, D., Deng, D., Weng, Y., Wang, S., Ma, D."C4orf7 contributes to ovarian cancer metastasis by promoting cancer cell migration and invasion ". Oncology Reports 24.4 (2010): 933-939.
Chicago
Wang, C., Zhou, L., Li, S., Wei, J., Wang, W., Zhou, T., Liao, S., Weng, D., Deng, D., Weng, Y., Wang, S., Ma, D."C4orf7 contributes to ovarian cancer metastasis by promoting cancer cell migration and invasion ". Oncology Reports 24, no. 4 (2010): 933-939. https://doi.org/10.3892/or_00000939
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