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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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November 2010 Volume 24 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 2010 Volume 24 Issue 5

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Article

Overexpression of BDNF and TrkB in human bladder cancer specimens

  • Authors:
    • Pei Chun Lai
    • Ted H. Chiu
    • Yen Ta Huang
  • View Affiliations / Copyright

    Affiliations: Institute of Pharmacology and Toxicology, Tzu Chi University, Hualien 970, Taiwan, R.O.C.
  • Pages: 1265-1270
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    Published online on: November 1, 2010
       https://doi.org/10.3892/or_00000981
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Abstract

BDNF (brain-derived neurotrophic factor) and TrkB (tropomyosin receptor kinase B) are expressed in several tumor types. However, the existence of BDNF and TrkB in human bladder cancer, especially transitional cell carcinoma (TCC), has not been established. In this study, commercial TCC tissue arrays were used. Slides of paraffin-fixed human bladder tissues included all grades of TCC (13, 30 and 22 tissue samples in grade I, II and III, respectively), superficial and invasive TCC (31 and 34 tissue samples, respectively), paired malignancy-uninvolved urothelium (35 tissue samples) and normal urothelial tissues (12 tissue samples). The intensities of BDNF and TrkB immunostaining were graded as background, mild and strong (score as 0, 1 and 2, respectively). The results showed significantly overexpressed BDNF and TrkB in TCC samples compared to normal urothelium. According to grade assignment of TCC samples, BDNF in grade III and TrkB in grade I and III appeared to be overexpressed. BDNF and TrkB were overexpressed in superficial TCC samples according to staging classification. The score between the paired TCC and its uninvolved urothelium was not statistically different. In conclusion, the existence of overexpressed BDNF and TrkB in human TCC has been demonstrated in our study. A strategy involving BDNF/TrkB blockade may be a new hope for TCC target therapy.

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Copy and paste a formatted citation
Spandidos Publications style
Lai PC, Chiu TH and Huang YT: Overexpression of BDNF and TrkB in human bladder cancer specimens . Oncol Rep 24: 1265-1270, 2010.
APA
Lai, P.C., Chiu, T.H., & Huang, Y.T. (2010). Overexpression of BDNF and TrkB in human bladder cancer specimens . Oncology Reports, 24, 1265-1270. https://doi.org/10.3892/or_00000981
MLA
Lai, P. C., Chiu, T. H., Huang, Y. T."Overexpression of BDNF and TrkB in human bladder cancer specimens ". Oncology Reports 24.5 (2010): 1265-1270.
Chicago
Lai, P. C., Chiu, T. H., Huang, Y. T."Overexpression of BDNF and TrkB in human bladder cancer specimens ". Oncology Reports 24, no. 5 (2010): 1265-1270. https://doi.org/10.3892/or_00000981
Copy and paste a formatted citation
x
Spandidos Publications style
Lai PC, Chiu TH and Huang YT: Overexpression of BDNF and TrkB in human bladder cancer specimens . Oncol Rep 24: 1265-1270, 2010.
APA
Lai, P.C., Chiu, T.H., & Huang, Y.T. (2010). Overexpression of BDNF and TrkB in human bladder cancer specimens . Oncology Reports, 24, 1265-1270. https://doi.org/10.3892/or_00000981
MLA
Lai, P. C., Chiu, T. H., Huang, Y. T."Overexpression of BDNF and TrkB in human bladder cancer specimens ". Oncology Reports 24.5 (2010): 1265-1270.
Chicago
Lai, P. C., Chiu, T. H., Huang, Y. T."Overexpression of BDNF and TrkB in human bladder cancer specimens ". Oncology Reports 24, no. 5 (2010): 1265-1270. https://doi.org/10.3892/or_00000981
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