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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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December 2010 Volume 24 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

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Article

Effects of the HDAC inhibitor CG2 in combination with irinotecan, 5-fluorouracil, or oxaliplatin on HCT116 colon cancer cells and xenografts

  • Authors:
    • Young-Soon Na
    • Seung-Mi Kim
    • Kyung-Ah Jung
    • Soo-Jin Yang
    • Yong Sang Hong
    • Min-Hee Ryu
    • Seonggu Ro
    • Dong-Hyung Cho
    • Jin Cheon Kim
    • Dong-Hoon Jin
    • Jung Shin Lee
    • Tae Won Kim

  • View Affiliations / Copyright

    Affiliations: Institute for Innovate Cancer Research, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
  • Pages: 1509-1514
    |
    Published online on: December 1, 2010
       https://doi.org/10.3892/or_00001012
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Abstract

Chemotherapies for colon cancer have recently advanced. However, there is still a need to develop agents and identify effective regimens for better treatments of colon cancer. Histone deacetylase inhibitors (HDACIs) have shown potential as anti-cancer agents. We investigated the anti-tumor effects of CG2 (an HDACI) in combination with irinotecan, 5-FU, or oxaliplatin. Combinations of CG2 with SN38 (the active form of irinotecan), 5FU, or oxaliplatin were more effective than the agents alone when used to inhibit the growth of HCT116 cells. The protein expressions of acetyl-H3, p21, caspase-3, -8, and -9, PARP, and XIAP were affected in a time- and dose-dependent manner in HCT116 cells treated with the CG2 alone or combined CG2 and SN-38. In HCT116 xenografts, the HDACI CG2 in combination with irinotecan dramatically inhibited tumor growth without showing additive toxicity. These data indicate that CG2 together with irinotecan is a promising combination novel treatment for colon cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Na Y, Kim S, Jung K, Yang S, Hong YS, Ryu M, Ro S, Cho D, Kim JC, Jin D, Jin D, et al: Effects of the HDAC inhibitor CG2 in combination with irinotecan, 5-fluorouracil, or oxaliplatin on HCT116 colon cancer cells and xenografts . Oncol Rep 24: 1509-1514, 2010.
APA
Na, Y., Kim, S., Jung, K., Yang, S., Hong, Y.S., Ryu, M. ... Kim, T.W. (2010). Effects of the HDAC inhibitor CG2 in combination with irinotecan, 5-fluorouracil, or oxaliplatin on HCT116 colon cancer cells and xenografts . Oncology Reports, 24, 1509-1514. https://doi.org/10.3892/or_00001012
MLA
Na, Y., Kim, S., Jung, K., Yang, S., Hong, Y. S., Ryu, M., Ro, S., Cho, D., Kim, J. C., Jin, D., Lee, J. S., Kim, T. W." Effects of the HDAC inhibitor CG2 in combination with irinotecan, 5-fluorouracil, or oxaliplatin on HCT116 colon cancer cells and xenografts ". Oncology Reports 24.6 (2010): 1509-1514.
Chicago
Na, Y., Kim, S., Jung, K., Yang, S., Hong, Y. S., Ryu, M., Ro, S., Cho, D., Kim, J. C., Jin, D., Lee, J. S., Kim, T. W." Effects of the HDAC inhibitor CG2 in combination with irinotecan, 5-fluorouracil, or oxaliplatin on HCT116 colon cancer cells and xenografts ". Oncology Reports 24, no. 6 (2010): 1509-1514. https://doi.org/10.3892/or_00001012
Copy and paste a formatted citation
x
Spandidos Publications style
Na Y, Kim S, Jung K, Yang S, Hong YS, Ryu M, Ro S, Cho D, Kim JC, Jin D, Jin D, et al: Effects of the HDAC inhibitor CG2 in combination with irinotecan, 5-fluorouracil, or oxaliplatin on HCT116 colon cancer cells and xenografts . Oncol Rep 24: 1509-1514, 2010.
APA
Na, Y., Kim, S., Jung, K., Yang, S., Hong, Y.S., Ryu, M. ... Kim, T.W. (2010). Effects of the HDAC inhibitor CG2 in combination with irinotecan, 5-fluorouracil, or oxaliplatin on HCT116 colon cancer cells and xenografts . Oncology Reports, 24, 1509-1514. https://doi.org/10.3892/or_00001012
MLA
Na, Y., Kim, S., Jung, K., Yang, S., Hong, Y. S., Ryu, M., Ro, S., Cho, D., Kim, J. C., Jin, D., Lee, J. S., Kim, T. W." Effects of the HDAC inhibitor CG2 in combination with irinotecan, 5-fluorouracil, or oxaliplatin on HCT116 colon cancer cells and xenografts ". Oncology Reports 24.6 (2010): 1509-1514.
Chicago
Na, Y., Kim, S., Jung, K., Yang, S., Hong, Y. S., Ryu, M., Ro, S., Cho, D., Kim, J. C., Jin, D., Lee, J. S., Kim, T. W." Effects of the HDAC inhibitor CG2 in combination with irinotecan, 5-fluorouracil, or oxaliplatin on HCT116 colon cancer cells and xenografts ". Oncology Reports 24, no. 6 (2010): 1509-1514. https://doi.org/10.3892/or_00001012
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