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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
December 2010 Volume 24 Issue 6

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Article

Rb family proteins in gastric cancer (Review)

Letizia Cito, Francesca Pentimalli, Iris Forte, Eliseo Mattioli, Antonio Giordano
Pages: 1411-1418
Published online on: 01 December 2010

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Article

Molecular targets for therapeutic interventions in human papillomavirus-related cancers (Review)

Alan Saito Ramalho, Anselmo Dantas Lopes, Aleylove Talans, Bruno Yoshihiro Parlato Sakiyama, Guilherme Luiz Stelko Pereira, Paulo Marcelo Hoff, Gilberto De Castro
Pages: 1419-1426
Published online on: 01 December 2010

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Article Open Access

Involvement of gicerin, a cell adhesion molecule, in the portal metastasis of rat colorectal adenocarcinoma cells

Kazuhide Adachi, Mahiro Hattori, Hidenori Kato, Marie Inai, Masaya Tsukamoto, Ekowati Handharyani, Eiichi Taira, Yasuhiro Tsukamoto
Pages: 1427-1431
Published online on: 01 December 2010

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Article Open Access

Evaluation of immune response according to the metastatic status in the regional lymph nodes in patients with gastric carcinoma

Keishi Nakamura, Itasu Ninomiya, Katsunobu Oyama, Masafumi Inokuchi, Shinichi Kinami, Sachio Fushida, Takashi Fujimura, Masato Kayahara, Tetsuo Ohta
Pages: 1433-1441
Published online on: 01 December 2010

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Article Open Access

Short GC-rich RNA similar to miR 1909 and 1915 folds in silico with the 5'-UTR and ORF of Notch and responders: Potential for the elimination of cancer stem cells

Yufeng Li, Takashi Mine, Constantin G. Ioannides
Pages: 1443-1453
Published online on: 01 December 2010

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Article

Cross-talk between NO and HMGB1 in lymphocytic thyroiditis and papillary thyroid cancer

Stefania Mardente, Alessandra Zicari, Fabrizio Consorti, Emanuela Mari, Maura Di Vito, Martina Leopizzi, Carlo Della Rocca, Alfredo Antonaci
Pages: 1455-1461
Published online on: 01 December 2010

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Article

Antitumor effects of nano-bubble hydrogen-dissolved water are enhanced by coexistent platinum colloid and the combined hyperthermia with apoptosis-like cell death

Ryoko Asada, Katsuhiro Kageyama, Hiroshi Tanaka, Hisakazu Matsui, Masatsugu Kimura, Yasukazu Saitoh, Nobuhiko Miwa
Pages: 1463-1470
Published online on: 01 December 2010

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Article

Anthocyanins are novel AMPKα1 stimulators that suppress tumor growth by inhibiting mTOR phosphorylation

Yun-Kyoung Lee, Won Sup Lee, Gon Sup Kim, Ock Jin Park
Pages: 1471-1477
Published online on: 01 December 2010

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Article

GROα promotes invasion of colorectal cancer cells

Hideo Ogata, Akira Sekikawa, Hidetsugu Yamagishi, Kazuhito Ichikawa, Shigeki Tomita, Johji Imura, Yuichi Ito, Masanori Fujita, Masahiro Tsubaki, Hiroyuki Kato, Takahiro Fujimori, Hirokazu Fukui
Pages: 1479-1486
Published online on: 01 December 2010

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Article

R-etodolac induces E-cadherin and suppresses colitis-related mouse colon tumorigenesis

Takuya Inoue, Mitsuyuki Murano, Yukiko Yoda, Takanori Kuramoto, Kazuki Kakimoto, Kumi Ishida, Ken Kawakami, Yosuke Abe, Eijiro Morita, Naoko Murano, Satoshi Tokioka, Kentaro Maemura, Eiji Umegaki, Kazuhide Higuchi
Pages: 1487-1492
Published online on: 01 December 2010

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Article

Regulation of mutual inhibitory activities between AMPK and Akt with quercetin in MCF-7 breast cancer cells

Yun-Kyoung Lee, Ock Jin Park
Pages: 1493-1497
Published online on: 01 December 2010

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Article

Novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines, induce cell cycle arrest and apoptosis in prostate cancer cells

Seema-Maria Nathwani, Suzanne M. Cloonan, Maeve Stronach, Giuseppe Campiani, Mark Lawler, D. Clive Williams, Daniela M. Zisterer
Pages: 1499-1507
Published online on: 01 December 2010

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Article

Effects of the HDAC inhibitor CG2 in combination with irinotecan, 5-fluorouracil, or oxaliplatin on HCT116 colon cancer cells and xenografts

Young-Soon Na, Seung-Mi Kim, Kyung-Ah Jung, Soo-Jin Yang, Yong Sang Hong, Min-Hee Ryu, Seonggu Ro, Dong-Hyung Cho, Jin Cheon Kim, Dong-Hoon Jin, Jung Shin Lee, Tae Won Kim
Pages: 1509-1514
Published online on: 01 December 2010

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Article

Effects of lysophosphatidic acid and its receptors LPA__AMB__frac13; on radiation pneumonitis

Jianxin Xue, Lu Gan, Xin Li, Jian Li, Guohai Qi, Yalan Wu, Xiaoyue Fu, Qing Mao, Rui Ao, Jingyi Lang, You Lu
Pages: 1515-1520
Published online on: 01 December 2010

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Article

Mitochondrial genotype and breast cancer predisposition

Anna M. Czarnecka, Tomasz Krawczyk, Katarzyna Plak, Aleksandra Klemba, Marek Zdrozny, Rebecca S. Arnold, Barbara Kofler, Pawel Golik, Aleksandra Szybinska, Jan Lubinski, Malgorzata Mossakowska, Ewa Bartnik, John A. Petros
Pages: 1521-1534
Published online on: 01 December 2010

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Article

Small bowel adenocarcinomas in celiac disease follow the CIM-MSI pathway

Frank Bergmann, Sandhya Singh, Sara Michel, Christoph Kahlert, Peter Schirmacher, Burkhard Helmke, Magnus Von Knebel Doeberitz, Matthias Kloor, Hendrik Bläker
Pages: 1535-1539
Published online on: 01 December 2010

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Article

Interaction between nuclear insulin receptor substrate-2 and NF-κB in IGF-1 induces response in breast cancer cells

Shufang Wu, Bo Zhou, Lin Xu, Hongzhi Sun
Pages: 1541-1550
Published online on: 01 December 2010

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Article

Telomerase suppression initiates PML-dependent p53 activation to inhibit bladder cancer cell growth

Yan Xue, Lei Li, Dong Zhang, Kaijie Wu, Peng Guo, Jin Zeng, Xinyang Wang, Dalin He
Pages: 1551-1559
Published online on: 01 December 2010

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Article

Tamoxifen-induced apoptosis of rat C6 glioma cells via PI3K/Akt, JNK and ERK activation

Ying Feng, Jintao Huang, Ying Ding, Fukang Xie, Xiaoyan Shen
Pages: 1561-1567
Published online on: 01 December 2010

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Article

Cytoplasmic and stromal expression of laminin γ 2 chain correlates with infiltrative invasion in ovarian mucinous neoplasms of gastro-intestinal type

Emi Okuma, Yoshihiro Ohishi, Yoshinao Oda, Shinichi Aishima, Shuichi Kurihara, Izumi Nishimura, Masafumi Yasunaga, Hiroaki Kobayashi, Norio Wake, Masazumi Tsuneyoshi
Pages: 1569-1576
Published online on: 01 December 2010

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Article

Expression of EphA1 in gastric carcinomas is associated with metastasis and survival

Jiandong Wang, Yingchun Dong, Xulin Wang, Henghui Ma, Zhen Sheng, Guli Li, Guangming Lu, Haruhiko Sugimura, Xiaojun Zhou
Pages: 1577-1584
Published online on: 01 December 2010

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Article

Allicin induces apoptosis in gastric cancer cells through activation of both extrinsic and intrinsic pathways

Wenlu Zhang, Minwen Ha, Yuehua Gong, Ying Xu, Nannan Dong, Yuan Yuan
Pages: 1585-1592
Published online on: 01 December 2010

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Article

The migration and invasion of human prostate cancer cell lines involves CD151 expression

Jian Ang, Bing-Liang Fang, Leonie K. Ashman, Albert G. Frauman
Pages: 1593-1597
Published online on: 01 December 2010

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Article

HPV-16 E6 upregulation of DNMT1 through repression of tumor suppressor p53

Chi Lam Au Yeung, Wing Pui Tsang, Tsun Yee Tsang, Ngai Na Co, Pak Lun Yau, Tim Tak Kwok
Pages: 1599-1604
Published online on: 01 December 2010

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Article

Adenovirus-mediated SOCS3 gene transfer inhibits the growth and enhances the radiosensitivity of human non-small cell lung cancer cells

Yu-Ching Lin, Chin-Kuo Lin, Ying-Huang Tsai, Hsu-Huei Weng, Ya-Chin Li, Liang You, Jan-Kan Chen, David M. Jablons, Cheng-Ta Yang
Pages: 1605-1612
Published online on: 01 December 2010

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Article

Synergistic gastric cancer inhibition by chemogenetherapy with recombinant human adenovirus p53 and epirubicin: an in vitro and in vivo study

Yi-Shan Xie, Yan-Hua Zhang, Shao-Ping Liu, Shi-Quan Liu, Chun-Wei Peng, Long Wu, He-Shen Luo, Yan Li
Pages: 1613-1620
Published online on: 01 December 2010

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Article

Sodium valproate, a histone deacetylase inhibitor, augments the expression of cell-surface NKG2D ligands, MICA/B, without increasing their soluble forms to enhance susceptibility of human osteosarcoma cells to NK cell-mediated cytotoxicity

Koji Yamanegi, Junko Yamane, Kenta Kobayashi, Nahoko Kato-Kogoe, Hideki Ohyama, Keiji Nakasho, Naoko Yamada, Masaki Hata, Toshihiro Nishioka, Satoru Fukunaga, Hiroyuki Futani, Haruki Okamura, Nobuyuki Terada
Pages: 1621-1627
Published online on: 01 December 2010

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Article

Cycling hypoxia increases U87 glioma cell radioresistance via ROS induced higher and long-term HIF-1 signal transduction activity

Chia-Hung Hsieh, Cheng-Hung Lee, Ji-An Liang, Chun-Yen Yu, Woei-Cherng Shyu
Pages: 1629-1636
Published online on: 01 December 2010

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Article

Transforming growth factor β signaling inhibitor, SB-431542, induces maturation of dendritic cells and enhances anti-tumor activity

Hiroaki Tanaka, Osamu Shinto, Masakazu Yashiro, Sadaaki Yamazoe, Takehiko Iwauchi, Kazuya Muguruma, Naoshi Kubo, Masaichi Ohira, Kosei Hirakawa
Pages: 1637-1643
Published online on: 01 December 2010

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Article

An explorative study on the clinical utility of baseline and serial serum tumour marker measurements in advanced upper gastrointestinal cancer

P. Byström, Å Berglund, P. Nygren, L. Wernroth, B. Johansson, A. Larsson, R. Einarsson, B. Glimelius
Pages: 1645-1652
Published online on: 01 December 2010

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Article

Growth and differentiation factor-9 promotes adhesive and motile capacity of prostate cancer cells by up-regulating FAK and Paxillin via Smad dependent pathway

Sivan M. Bokobza, Lin Ye, Howard G. Kynaston, Wen G. Jiang
Pages: 1653-1659
Published online on: 01 December 2010

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Article

BRCA1 and BRCA2 genetic test in high risk patients and families: counselling and management

Eleonora Marchina, Maria Grazia Fontana, Michela Speziani, Alessandro Salvi, Giuseppe Ricca, Diego Di Lorenzo, Maria Gervasi, Luigi Caimi, Sergio Barlati
Pages: 1661-1667
Published online on: 01 December 2010

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Article

The β-adrenoceptor antagonist, propranolol, induces human gastric cancer cell apoptosis and cell cycle arrest via inhibiting nuclear factor κB signaling

Xinhua Liao, Xiangming Che, Wei Zhao, Danjie Zhang, Tieqiang Bi, Guanghui Wang
Pages: 1669-1676
Published online on: 01 December 2010

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Article

Inhibition of activated phosphatidylinositol 3-kinase/AKT pathway in malignant pleural mesothelioma leads to G1 cell cycle arrest

Iwao Mikami, Fang Zhang, Tomomi Hirata, Junichi Okamoto, Kiyoshi Koizumi, Kazuo Shimizu, David Jablons, Biao He
Pages: 1677-1681
Published online on: 01 December 2010

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Article

Inhibition of PI3 kinases enhances the sensitivity of non-small cell lung cancer cells to ionizing radiation

Tao Zhang, Guang-Bin Cui, Jian Zhang, Feng Zhang, Yong-An Zhou, Tao Jiang, Xiao-Fei Li
Pages: 1683-1689
Published online on: 01 December 2010

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Journal Cover
March-2026 Volume 55 Issue 3

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

Collaborative breakthroughs in precision diagnosis and treatment of nasopharyngeal cancer: Biomarker‑driven screening and endoscopic minimally invasive surgery reshape the new paradigm of early intervention (Review)

E Jin, Wang Lin, Xiandong Zeng
Article Number: 53
Published online on: 23 January 2026

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Review Open Access

Key immune cells in the tumor immune microenvironment of colorectal cancer: Roles and research advances (Review)

Ming Qiu, Chongyuan Lan, Minglin Lin, Hui Ma
Article Number: 52
Published online on: 21 January 2026

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Correction Open Access

[Corrigendum] Icaritin acts synergistically with epirubicin to suppress bladder cancer growth through inhibition of autophagy

Xiu-Wu Pan, Lin Li, Yi Huang, Hai Huang, Dan-Feng Xu, Yi Gao, Lu Chen, Ji-Zhong Ren, Jian-Wei Cao, Yi Hong, Xin-Gang Cui
Article Number: 51
Published online on: 21 January 2026

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Review Open Access

Epigenetic mechanisms and therapeutic advances in diffuse midline glioma (Review)

Wenbo Wu, Wenlin Chen, Wenbin Ma, Yu Wang
Article Number: 50
Published online on: 20 January 2026

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Review Open Access

Recapitulating lung cancer metastasis in vitro: Advances in organoid models and challenges in clinical translation (Review)

Jian Jiang, Guomin Dong, Zhiyun Zhang, Xiaoyuan Lei, Fanshu Huang, Suoni Li, Jiequn Ma, Jie Bai, Qian Ge, Hui Wei, Zheng Zhao
Article Number: 49
Published online on: 20 January 2026

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Article Open Access

GPR176 enhances the epithelial‑mesenchymal transition in gastric cancer cells by activating the PI3K/AKT/mTOR signaling pathway

Guangchuan Mu, Kaiyan Li, Chaozhen Hu, Jintao Cai, Huichao Ruan, Guanyu Zhu, Dang Liu
Article Number: 48
Published online on: 19 January 2026

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Article Open Access

HMBOX1 inhibits hepatocellular carcinoma progression via PTPN1 mediated AKT1 phosphorylation

Chenning Zhang, Yu Jiang, Jiahui Liu, Wenyu Zhang, Jie Qi, Qing Wen, Hengli Zhao
Article Number: 47
Published online on: 19 January 2026

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Retraction Open Access

[Retracted] Prognostic significance of miR‑218 in human hepatocellular carcinoma and its role in cell growth

Kangsheng Tu, Chao Li, Xin Zheng, Wei Yang, Yingmin Yao, Qingguang Liu
Article Number: 46
Published online on: 19 January 2026

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Review Open Access

Tumor microenvironment in bone sarcomas: Implications for immunotherapy and emerging therapeutic vulnerabilities (Review)

Wentao Li, Lijun Lv, Yibin Jin, Xin Yuan
Article Number: 45
Published online on: 16 January 2026

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Review Open Access

Immunotherapy after EGFR‑TKI treatment in advanced non‑small cell lung cancer: Current status and future perspectives (Review)

Huiyuan Ma, Longhui Li, Conghan Jiao, Yanyan Cheng, Jiayu He, Chen Jiang, Qian Tong, Dan Yi, Ying Zhang
Article Number: 44
Published online on: 16 January 2026

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Correction Open Access

[Corrigendum] Triptolide inhibits JAK2/STAT3 signaling and induces lethal autophagy through ROS generation in cisplatin‑resistant SKOV3/DDP ovarian cancer cells

Yanying Zhong, Fuyin Le, Jiao Cheng, Chen Luo, Xiali Zhang, Xingwu Wu, Fang Xu, Qi Zuo, Buzhen Tan
Article Number: 43
Published online on: 13 January 2026

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Review Open Access

Role of tumor‑infiltrating lymphocytes and miR‑155 in breast cancer: Insights into carcinogenesis and their potential as prognostic biomarkers (Review)

Miriam Monteiro Alvares‑Vilela, Franciele Schlemmer, Sabrina Simplício de Araújo Romero Ferrari, Mary-Ann Elvina Xavier, Ricardo Titze‑de‑Almeida
Article Number: 42
Published online on: 14 January 2026

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Article Open Access

CDK1 depletion suppresses glioma malignancy through cell cycle pathway regulation: Mechanistic insights from functional and molecular profiling

Yu Wang, Huandi Zhou, Xuetao Han, Dongdong Zhang, Liubing Hou, Haonan Li, Tianyi Fan, Sijie Li, Xiaoying Xue
Article Number: 41
Published online on: 12 January 2026

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Retraction Open Access

[Retracted] Downregulated microRNA‑200a promotes EMT and tumor growth through the Wnt/β‑catenin pathway by targeting the E‑cadherin repressors ZEB1/ZEB2 in gastric adenocarcinoma

Ningning Cong, Ping Du, Anling Zhang, Fajuan Shen, Juan Su, Peiyu Pu, Tao Wang, Jie Zjang, Chunsheng Kang, Qingyu Zhang
Article Number: 40
Published online on: 12 January 2026

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Review Open Access

Advances in targeting KRAS mutations: A promising approach for the treatment of non‑small cell lung cancer (Review)

Upesh Sharma, Jincheng Song, Hemraj Kandu, Yue Zhu, Zhaoxia Dai
Article Number: 39
Published online on: 08 January 2026

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Correction Open Access

[Corrigendum] CXCR6 predicts poor prognosis in gastric cancer and promotes tumor metastasis through epithelial-mesenchymal transition

Jie-Jie Jin, Fa-Xiang Dai, Zi-Wen Long, Hong Cai, Xiao-Wen Liu, Ye Zhou, Qi Hong, Qiong-Zhu Dong, Ya-Nong Wang, Hua Huang
Article Number: 38
Published online on: 05 January 2026

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Journal Cover
April-2026 Volume 55 Issue 4

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Article Open Access

Quercetin reduces expression of ATP‑binding cassette transporters by regulating the PTEN/PI3K/AKT signaling pathway in breast cancer cells

Wentao Fu, Leying Lin, Jie Li, Fei Qin, Chuan Chen, Yinglian Cai, Yilun Cai, Yiling Huang, Wang Yang, Shanshan Zhu
Article Number: 63
Published online on: 02 February 2026

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Article Open Access

POSTN+ fibroblast‑secreted small extracellular vesicles drive macrophage M2 polarization through BMP4/BMPR2/Smad signaling

Chenyang Zhang, Si Chen, Chenghui Qian, Wanqi Lv, Qian Zhang, Yanjin Wang, Yuqiong Wu, Xue Liu
Article Number: 62
Published online on: 02 February 2026

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Retraction Open Access

[Retracted] EGFR/HER2 inhibitors effectively reduce the malignant potential of MDR breast cancer evoked by P‑gp substrates in vitro and in vivo

Yiting Jin, Wei Zhang, Hongying Wang, Zijing Zhang, Chengyu Chu, Xiuping Liu, Qiang Zou
Article Number: 61
Published online on: 02 February 2026

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Article

Tumor‑associated glucocorticoid inhibition by mifepristone reduces polymorphonuclear myeloid‑derived suppressor cells and promotes antitumor immunity in triple‑negative breast cancer‑bearing mice

Masato Kobayashi, Chisana Konno, Ayato Shimizu, Masanori Kobayashi, Tatsuya Hori
Article Number: 60
Published online on: 30 January 2026

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Review Open Access

Mitochondria in T‑cell tumor immunity and tumor therapies targeting mitochondria (Review)

Minjie Zhou, Yijie Xie, Zhipeng Liu, Yi He, Yibing Yin, Keyu Chen, Zhengyu Zhao, Chengshun Zhang, Dingjun Cai
Article Number: 59
Published online on: 29 January 2026

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TRIM46 deficiency‑induced DNA damage enhances the sensitivity of cisplatin in non‑small cell lung cancer by regulating the Akt signaling pathway

Song Jin, Dandan Zhang, Zhicheng Liao, Lingpei Yu, Yuanyuan Wang, Pengcheng Jia, Minmin Pan, Yifan Li, Jizhou Zhang
Article Number: 58
Published online on: 28 January 2026

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Review Open Access

Advances in isolation and detection technologies and immunotherapy applications of circulating tumor cells (Review)

Ping Zhou, Qin Ye, Yiyun Huang, Yumei Feng, Li Zhou, Ke Xie
Article Number: 57
Published online on: 28 January 2026

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Correction Open Access

[Corrigendum] 3‑Bromopyruvate sensitizes human breast cancer cells to TRAIL‑induced apoptosis via the phosphorylated AMPK‑mediated upregulation of DR5

Yuzhong Chen, Li Wei, Xiaojing Zhang, Xianfu Liu, Yansong Chen, Song Zhang, Lanzhu Zhou, Qixiang Li, Qiong Pan, Surong Zhao, Hao Liu
Article Number: 56
Published online on: 28 January 2026

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High RMI1 expression is associated with cancer cell progression and poor prognosis in prostate cancer

Pengliang Shen, Xiaosong Wang, Xiaoting Yan, Hongyang Du, Bo Wu, Xiaoming Cao
Article Number: 55
Published online on: 27 January 2026

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Retraction Open Access

[Retracted] MicroRNA‑615‑5p targets insulin‑like growth factor 2 and exerts tumor‑suppressing functions in human esophageal squamous cell carcinoma

Bingyin Yang, Rui Xie, Shang-Nong Wu, Cheng-Cheng Gao, Xiao-Zhong Yang, Jing-Fang Zhou
Article Number: 54
Published online on: 26 January 2026

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