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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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December 2010 Volume 24 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Effects of lysophosphatidic acid and its receptors LPA__AMB__frac13; on radiation pneumonitis

  • Authors:
    • Jianxin Xue
    • Lu Gan
    • Xin Li
    • Jian Li
    • Guohai Qi
    • Yalan Wu
    • Xiaoyue Fu
    • Qing Mao
    • Rui Ao
    • Jingyi Lang
    • You Lu

  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Oncology, Cancer Center, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, P.R. China
  • Pages: 1515-1520
    |
    Published online on: December 1, 2010
       https://doi.org/10.3892/or_00001013
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Abstract

Radiation pneumonitis (RP) is a serious complication of radiation therapy for thoracic tumors. Lysophosphatidic acid (LPA) and its receptors LPA__AMB__frac13; were reported to participate in the processes of inflammation. We tested the hypothesis that LPA and its receptors LPA__AMB__frac13;, take part in the pathogenesis of RP. In our study, irradiation increased LPA levels in the lung and expression of LPA__AMB__frac13;. To further determine the role of LPA__AMB__frac13;, we performed pharmacological knockout of LPA__AMB__frac13; by a specific antagonist, VPC-12249. On day 60 post-irradiation, RP was significantly alleviated in a dose-dependent manner in mice treated with VPC-12249, as shown by H&E staining, malondialdehyde (MDA, an indicator of oxidative damage) assay in lung, and concentrations of proinflammatory and profibrotic cytokines in plasma, including IL-1β, TNF-α, and TGF-β1. Additionally, VPC-12249 administration decreased the phosphorylation of IκB-α (the initial event that activates the NF-κB signal way), and expression of TGF-β1, CTGF, and α-SMA mRNA. Our findings suggest that LPA and LPA__AMB__frac13; may play a pivotal role in RP, and LPA-LPA__AMB__frac13; may serve as novel therapeutic targets for the treatment of RP.

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Copy and paste a formatted citation
Spandidos Publications style
Xue J, Gan L, Li X, Li J, Qi G, Wu Y, Fu X, Mao Q, Ao R, Lang J, Lang J, et al: Effects of lysophosphatidic acid and its receptors LPA__AMB__frac13; on radiation pneumonitis . Oncol Rep 24: 1515-1520, 2010.
APA
Xue, J., Gan, L., Li, X., Li, J., Qi, G., Wu, Y. ... Lu, Y. (2010). Effects of lysophosphatidic acid and its receptors LPA__AMB__frac13; on radiation pneumonitis . Oncology Reports, 24, 1515-1520. https://doi.org/10.3892/or_00001013
MLA
Xue, J., Gan, L., Li, X., Li, J., Qi, G., Wu, Y., Fu, X., Mao, Q., Ao, R., Lang, J., Lu, Y."Effects of lysophosphatidic acid and its receptors LPA__AMB__frac13; on radiation pneumonitis ". Oncology Reports 24.6 (2010): 1515-1520.
Chicago
Xue, J., Gan, L., Li, X., Li, J., Qi, G., Wu, Y., Fu, X., Mao, Q., Ao, R., Lang, J., Lu, Y."Effects of lysophosphatidic acid and its receptors LPA__AMB__frac13; on radiation pneumonitis ". Oncology Reports 24, no. 6 (2010): 1515-1520. https://doi.org/10.3892/or_00001013
Copy and paste a formatted citation
x
Spandidos Publications style
Xue J, Gan L, Li X, Li J, Qi G, Wu Y, Fu X, Mao Q, Ao R, Lang J, Lang J, et al: Effects of lysophosphatidic acid and its receptors LPA__AMB__frac13; on radiation pneumonitis . Oncol Rep 24: 1515-1520, 2010.
APA
Xue, J., Gan, L., Li, X., Li, J., Qi, G., Wu, Y. ... Lu, Y. (2010). Effects of lysophosphatidic acid and its receptors LPA__AMB__frac13; on radiation pneumonitis . Oncology Reports, 24, 1515-1520. https://doi.org/10.3892/or_00001013
MLA
Xue, J., Gan, L., Li, X., Li, J., Qi, G., Wu, Y., Fu, X., Mao, Q., Ao, R., Lang, J., Lu, Y."Effects of lysophosphatidic acid and its receptors LPA__AMB__frac13; on radiation pneumonitis ". Oncology Reports 24.6 (2010): 1515-1520.
Chicago
Xue, J., Gan, L., Li, X., Li, J., Qi, G., Wu, Y., Fu, X., Mao, Q., Ao, R., Lang, J., Lu, Y."Effects of lysophosphatidic acid and its receptors LPA__AMB__frac13; on radiation pneumonitis ". Oncology Reports 24, no. 6 (2010): 1515-1520. https://doi.org/10.3892/or_00001013
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