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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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December 2010 Volume 24 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Synergistic gastric cancer inhibition by chemogenetherapy with recombinant human adenovirus p53 and epirubicin: an in vitro and in vivo study

  • Authors:
    • Yi-Shan Xie
    • Yan-Hua Zhang
    • Shao-Ping Liu
    • Shi-Quan Liu
    • Chun-Wei Peng
    • Long Wu
    • He-Shen Luo
    • Yan Li

  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Renmin Hospital of Wuhan University, Wuhan 430060, P.R. China
  • Pages: 1613-1620
    |
    Published online on: December 1, 2010
       https://doi.org/10.3892/or_00001025
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Abstract

This study was desinged to investigate the in vitro and in vivo antitumor effect on SGC-7901 gastric cancer cells by chemogenetherapy. SGC-7901 cells were treated by chemogenetherapy with Gendicine, a recombinant human Ad-p53 injection (rAd-p53), and epirubicin hydrochloride (EPI), a cytotoxic chemotherapy agent. Compared with blank control, rAd-p53, EPI, and combined therapy achieved SGC-7901 growth inhibition by 32.26, 35.48, 43.44%, respectively on day 1 and 70.62, 78.82, 87.15%, respectively on day 2 (rAd-p53, EPI VS control, p<0.01; rAd-p53+EPI VS either alone, p<0.05). Flow cytometry study confirmed that rAd-p53 and/or EPI mainly inhibit the cell cycle at S phase. SGC-7901 cells were subcutaneously injected into the nude mice to form xenograft models, which were treated with rAd-p53 and EPI. Compared with the blank control, treatment with rAd-p53 at the dose of 10 µl of 1012 vp/ml and EPI at the dose of 1.25 mg/kg, 7 times in 3 weeks, resulted in 80 and 60% of tumor growth inhibition, respectively. No animal death was observed, although 2 nude mice in rAd-p53 group developed liver toxicity and 1 nude mouse in EPI group developed cardiac toxicity. rAd-p53 and EPI have synergistic tumor inhibition effect on gastric cancer cells.

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Copy and paste a formatted citation
Spandidos Publications style
Xie Y, Zhang Y, Liu S, Liu S, Peng C, Wu L, Luo H and Li Y: Synergistic gastric cancer inhibition by chemogenetherapy with recombinant human adenovirus p53 and epirubicin: an in vitro and in vivo study . Oncol Rep 24: 1613-1620, 2010.
APA
Xie, Y., Zhang, Y., Liu, S., Liu, S., Peng, C., Wu, L. ... Li, Y. (2010). Synergistic gastric cancer inhibition by chemogenetherapy with recombinant human adenovirus p53 and epirubicin: an in vitro and in vivo study . Oncology Reports, 24, 1613-1620. https://doi.org/10.3892/or_00001025
MLA
Xie, Y., Zhang, Y., Liu, S., Liu, S., Peng, C., Wu, L., Luo, H., Li, Y."Synergistic gastric cancer inhibition by chemogenetherapy with recombinant human adenovirus p53 and epirubicin: an in vitro and in vivo study ". Oncology Reports 24.6 (2010): 1613-1620.
Chicago
Xie, Y., Zhang, Y., Liu, S., Liu, S., Peng, C., Wu, L., Luo, H., Li, Y."Synergistic gastric cancer inhibition by chemogenetherapy with recombinant human adenovirus p53 and epirubicin: an in vitro and in vivo study ". Oncology Reports 24, no. 6 (2010): 1613-1620. https://doi.org/10.3892/or_00001025
Copy and paste a formatted citation
x
Spandidos Publications style
Xie Y, Zhang Y, Liu S, Liu S, Peng C, Wu L, Luo H and Li Y: Synergistic gastric cancer inhibition by chemogenetherapy with recombinant human adenovirus p53 and epirubicin: an in vitro and in vivo study . Oncol Rep 24: 1613-1620, 2010.
APA
Xie, Y., Zhang, Y., Liu, S., Liu, S., Peng, C., Wu, L. ... Li, Y. (2010). Synergistic gastric cancer inhibition by chemogenetherapy with recombinant human adenovirus p53 and epirubicin: an in vitro and in vivo study . Oncology Reports, 24, 1613-1620. https://doi.org/10.3892/or_00001025
MLA
Xie, Y., Zhang, Y., Liu, S., Liu, S., Peng, C., Wu, L., Luo, H., Li, Y."Synergistic gastric cancer inhibition by chemogenetherapy with recombinant human adenovirus p53 and epirubicin: an in vitro and in vivo study ". Oncology Reports 24.6 (2010): 1613-1620.
Chicago
Xie, Y., Zhang, Y., Liu, S., Liu, S., Peng, C., Wu, L., Luo, H., Li, Y."Synergistic gastric cancer inhibition by chemogenetherapy with recombinant human adenovirus p53 and epirubicin: an in vitro and in vivo study ". Oncology Reports 24, no. 6 (2010): 1613-1620. https://doi.org/10.3892/or_00001025
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