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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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January 2011 Volume 25 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 2011 Volume 25 Issue 1

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Article

The expression profile of apoptosis-related genes in the chicken as a human epithelial ovarian cancer model

  • Authors:
    • Hee Won Seo
    • Deivendran Rengaraj
    • Jin Won Choi
    • Kyung Je Park
    • Gwonhwa Song
    • Jae Yong Han

  • View Affiliations / Copyright

    Affiliations: WCU Biomodulation Major, Department of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul 151-921, Republic of Korea
  • Pages: 49-56
    |
    Published online on: January 1, 2011
       https://doi.org/10.3892/or_00001040
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Abstract

The purpose of our study was to examine the expression pattern of apoptosis-related genes in normal and cancerous ovaries of the hen. Localization of apoptosis-related gene mRNA was investigated in cancerous ovaries using in situ hybridization. The expression patterns of apoptosis-related genes were confirmed with RT-PCR in normal and cancerous ovaries. Differences of expression level between normal ovaries and ovarian cancers were analyzed using quantitative RT-PCR. In both normal and cancerous chicken ovaries, the expression of CASP1, CASP2, CASP3, CASP6, CASP8 and CASP9 were detected through RT-PCR analysis. The expression of BCL2, BCL2L1 and BID were confirmed in normal and cancerous ovaries of the hen. Quantitative RT-PCR showed that CASP1 expression was significantly increased in cancerous ovaries compared with normal ovaries, whereas BID expression was decreased. Our results showed a resistance to removal of abnormal cells via apoptosis in cancerous ovaries of the hen. Collectively, this phenomenon is closely associated with the dysregulation of CASP1 and BID expression in chicken ovarian cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Seo HW, Rengaraj D, Choi JW, Park KJ, Song G and Han JY: The expression profile of apoptosis-related genes in the chicken as a human epithelial ovarian cancer model . Oncol Rep 25: 49-56, 2011.
APA
Seo, H.W., Rengaraj, D., Choi, J.W., Park, K.J., Song, G., & Han, J.Y. (2011). The expression profile of apoptosis-related genes in the chicken as a human epithelial ovarian cancer model . Oncology Reports, 25, 49-56. https://doi.org/10.3892/or_00001040
MLA
Seo, H. W., Rengaraj, D., Choi, J. W., Park, K. J., Song, G., Han, J. Y."The expression profile of apoptosis-related genes in the chicken as a human epithelial ovarian cancer model ". Oncology Reports 25.1 (2011): 49-56.
Chicago
Seo, H. W., Rengaraj, D., Choi, J. W., Park, K. J., Song, G., Han, J. Y."The expression profile of apoptosis-related genes in the chicken as a human epithelial ovarian cancer model ". Oncology Reports 25, no. 1 (2011): 49-56. https://doi.org/10.3892/or_00001040
Copy and paste a formatted citation
x
Spandidos Publications style
Seo HW, Rengaraj D, Choi JW, Park KJ, Song G and Han JY: The expression profile of apoptosis-related genes in the chicken as a human epithelial ovarian cancer model . Oncol Rep 25: 49-56, 2011.
APA
Seo, H.W., Rengaraj, D., Choi, J.W., Park, K.J., Song, G., & Han, J.Y. (2011). The expression profile of apoptosis-related genes in the chicken as a human epithelial ovarian cancer model . Oncology Reports, 25, 49-56. https://doi.org/10.3892/or_00001040
MLA
Seo, H. W., Rengaraj, D., Choi, J. W., Park, K. J., Song, G., Han, J. Y."The expression profile of apoptosis-related genes in the chicken as a human epithelial ovarian cancer model ". Oncology Reports 25.1 (2011): 49-56.
Chicago
Seo, H. W., Rengaraj, D., Choi, J. W., Park, K. J., Song, G., Han, J. Y."The expression profile of apoptosis-related genes in the chicken as a human epithelial ovarian cancer model ". Oncology Reports 25, no. 1 (2011): 49-56. https://doi.org/10.3892/or_00001040
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