Occult neoplastic cells in the lymph node sinuses and recurrence/metastasis of stage II/Dukes' B colorectal cancer

  • Authors:
    • Yasutomo Sekido
    • Masaya Mukai
    • Kyoko Kishima
    • Takayuki Tajima
    • Tatsuhiko Hoshikawa
    • Masato Nakamura
    • Naoya Nakamura
    • Kyoji Ogoshi
  • View Affiliations

  • Published online on: January 1, 2011     https://doi.org/10.3892/or_00001043
  • Pages: 69-73
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Abstract

Lymph nodes from patients with colorectal cancer were immunohistochemically stained for cytokeratin in order to investigate the relationship between the presence of occult neoplastic cells (ONCs) and recurrence/metastasis. A total of 78 patients with stage II/Dukes' B colorectal cancer were divided into two groups. The first group consisted of 18 patients who had developed recurrence/metastasis (recurrence group) and the other one of 60 patients who had survived without recurrence (non-recurrence group). The presence of ONCs was compared between the two groups with respect to i) single cells (≥3 floating ONCs), ii) clusters of cells (≥1 floating aggregates of 2-20 ONCs), and iii) single cells + clusters. When single cells were detected, the sensitivity for recurrence was 55.6% (10/18), the positive predictive value (PPV) was 30.3% (10/33), the specificity was 61.7% (37/60, p=0.195), and the negative predictive value (NPV) was 82.2%(37/45). For the clusters, the sensitivity was 55.6% (10/18), PPV was 37% (10/27), specificity was 71.7% (43/60, p=0.033), and NPV was 84.3% (43/51). With single cells + clusters, the values were 55.6% (10/18), 43.5% (10/23), 78.3% (47/60, p=0.006), and 85.5% (47/55), respectively. These results suggest that the detection of single cells + clusters has a high specificity and NPV, and indicates a low risk of recurrence/metastasis in patients with stage II colorectal cancer.

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January 2011
Volume 25 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Sekido Y, Mukai M, Kishima K, Tajima T, Hoshikawa T, Nakamura M, Nakamura N and Ogoshi K: Occult neoplastic cells in the lymph node sinuses and recurrence/metastasis of stage II/Dukes' B colorectal cancer . Oncol Rep 25: 69-73, 2011
APA
Sekido, Y., Mukai, M., Kishima, K., Tajima, T., Hoshikawa, T., Nakamura, M. ... Ogoshi, K. (2011). Occult neoplastic cells in the lymph node sinuses and recurrence/metastasis of stage II/Dukes' B colorectal cancer . Oncology Reports, 25, 69-73. https://doi.org/10.3892/or_00001043
MLA
Sekido, Y., Mukai, M., Kishima, K., Tajima, T., Hoshikawa, T., Nakamura, M., Nakamura, N., Ogoshi, K."Occult neoplastic cells in the lymph node sinuses and recurrence/metastasis of stage II/Dukes' B colorectal cancer ". Oncology Reports 25.1 (2011): 69-73.
Chicago
Sekido, Y., Mukai, M., Kishima, K., Tajima, T., Hoshikawa, T., Nakamura, M., Nakamura, N., Ogoshi, K."Occult neoplastic cells in the lymph node sinuses and recurrence/metastasis of stage II/Dukes' B colorectal cancer ". Oncology Reports 25, no. 1 (2011): 69-73. https://doi.org/10.3892/or_00001043