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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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January 2011 Volume 25 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 2011 Volume 25 Issue 1

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Article

Troglitazone attenuates epidermal growth factor receptor signaling independently of peroxisome proliferator-activated receptor in PC-3 cells

  • Authors:
    • Hai Zhu
    • Xiaojing Pan
    • Haiyan Qi
    • Xuechun Wang
    • Sichuan Hou
    • Baojian Han
    • Zhijun Liu
    • Luo Xu

  • View Affiliations / Copyright

    Affiliations: Department of Pathophysiology, Medical College of Qingdao University, Qingdao, P.R. China
  • Pages: 81-90
    |
    Published online on: January 1, 2011
       https://doi.org/10.3892/or_00001045
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Abstract

The role of the peroxisome proliferator-activated receptor-γ (PPARγ) in cell differentiation, cell cycle arrest and apoptosis has attracted increasing attention. Troglitazone (TGZ), a thiazolidinedione ligand of PPARγ, has been recently described as possessing antitumoral properties. We studied the effects of TGZ on proliferation, growth arrest and apoptosis in PC-3 prostate carcinoma cells and its interaction with the signaling pathways of the activated EFG receptor (EGFR). We observed that TGZ, in a dose- and time-dependent manner, inhibited the growth of PC-3 cells independent of PPARγ. In addition, TGZ induced cell cycle arrest and apoptosis. We demonstrated that cell proliferation was stimulated by EFG in a dose- and time-dependent manner and was inhibited by TGZ. The analysis of the main intracellular signaling pathways downstream of the activated EGFR, PI3K-Akt, ERK1/2 cascades and IκBα revealed that TGZ reduced the phosphorylation levels of EGFR and of their downstream inter-mediators which mediate EGF stimulated proliferation. In conclusion, simultaneous targeting of EGFR, PI3K-Akt, ERK1/2 and NF-κB by TGZ could be the molecular mechanism by which TGZ exerts its additive inhibitory effects on PC-3 cell proliferation.

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Copy and paste a formatted citation
Spandidos Publications style
Zhu H, Pan X, Qi H, Wang X, Hou S, Han B, Liu Z and Xu L: Troglitazone attenuates epidermal growth factor receptor signaling independently of peroxisome proliferator-activated receptor in PC-3 cells . Oncol Rep 25: 81-90, 2011.
APA
Zhu, H., Pan, X., Qi, H., Wang, X., Hou, S., Han, B. ... Xu, L. (2011). Troglitazone attenuates epidermal growth factor receptor signaling independently of peroxisome proliferator-activated receptor in PC-3 cells . Oncology Reports, 25, 81-90. https://doi.org/10.3892/or_00001045
MLA
Zhu, H., Pan, X., Qi, H., Wang, X., Hou, S., Han, B., Liu, Z., Xu, L."Troglitazone attenuates epidermal growth factor receptor signaling independently of peroxisome proliferator-activated receptor in PC-3 cells ". Oncology Reports 25.1 (2011): 81-90.
Chicago
Zhu, H., Pan, X., Qi, H., Wang, X., Hou, S., Han, B., Liu, Z., Xu, L."Troglitazone attenuates epidermal growth factor receptor signaling independently of peroxisome proliferator-activated receptor in PC-3 cells ". Oncology Reports 25, no. 1 (2011): 81-90. https://doi.org/10.3892/or_00001045
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu H, Pan X, Qi H, Wang X, Hou S, Han B, Liu Z and Xu L: Troglitazone attenuates epidermal growth factor receptor signaling independently of peroxisome proliferator-activated receptor in PC-3 cells . Oncol Rep 25: 81-90, 2011.
APA
Zhu, H., Pan, X., Qi, H., Wang, X., Hou, S., Han, B. ... Xu, L. (2011). Troglitazone attenuates epidermal growth factor receptor signaling independently of peroxisome proliferator-activated receptor in PC-3 cells . Oncology Reports, 25, 81-90. https://doi.org/10.3892/or_00001045
MLA
Zhu, H., Pan, X., Qi, H., Wang, X., Hou, S., Han, B., Liu, Z., Xu, L."Troglitazone attenuates epidermal growth factor receptor signaling independently of peroxisome proliferator-activated receptor in PC-3 cells ". Oncology Reports 25.1 (2011): 81-90.
Chicago
Zhu, H., Pan, X., Qi, H., Wang, X., Hou, S., Han, B., Liu, Z., Xu, L."Troglitazone attenuates epidermal growth factor receptor signaling independently of peroxisome proliferator-activated receptor in PC-3 cells ". Oncology Reports 25, no. 1 (2011): 81-90. https://doi.org/10.3892/or_00001045
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