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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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January 2011 Volume 25 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Immunolabelling of the inhibin/activin-βC subunit in normal and malignant human uterine cervical tissue and cervical cancer cell lines

  • Authors:
    • Thomas Blankenstein
    • Julia Jückstock
    • Naim Shabani
    • Susanne Kunze
    • Ansgar Brüning
    • Florian Bergauer
    • Ioannis Mylonas

  • View Affiliations / Copyright

    Affiliations: First Department of Obstetrics and Gynaecology, Ludwig-Maximilians-University Munich, Germany
  • Pages: 147-152
    |
    Published online on: January 1, 2011
       https://doi.org/10.3892/or_00001054
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Abstract

Inhibins are dimeric glycoproteins, composed of an α-subunit and one of two possible β-subunits (βA or βB), with substantial roles in human reproduction and in endocrine-responsive tumours. Recently a novel β subunit named βC was described, although it is still unclear if normal or cancerous cervical epithelial cells as well as cervical cancer cell lines can synthesise the inhibin-βC subunit. Four normal cervical tissue samples together with specimens of well-differentiated squamous cervical cancer and adenocarcinoma of the cervix were immunohistochemically analyzed. Additionally, two cervical carcinoma cell lines (HeLa and CaSKi) were analyzed by immunofluorescence for the expression of this novel subunit. We demonstrated for the first time an immunolabelling of the inhibin-βC subunit in normal and malignant cervical tissue, as well as cervical cancer cells. Although the physiological role is still unclear in cervical tissue, the inhibin-βC subunit might play important roles in carcinogenesis. Moreover, the synthesis of this subunit in cervical carcinoma cell lines of squamous and epithelial origins allows the use of these cell lines in elucidating its functions in cervical pathogenesis.

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Copy and paste a formatted citation
Spandidos Publications style
Blankenstein T, Jückstock J, Shabani N, Kunze S, Brüning A, Bergauer F and Mylonas I: Immunolabelling of the inhibin/activin-βC subunit in normal and malignant human uterine cervical tissue and cervical cancer cell lines . Oncol Rep 25: 147-152, 2011.
APA
Blankenstein, T., Jückstock, J., Shabani, N., Kunze, S., Brüning, A., Bergauer, F., & Mylonas, I. (2011). Immunolabelling of the inhibin/activin-βC subunit in normal and malignant human uterine cervical tissue and cervical cancer cell lines . Oncology Reports, 25, 147-152. https://doi.org/10.3892/or_00001054
MLA
Blankenstein, T., Jückstock, J., Shabani, N., Kunze, S., Brüning, A., Bergauer, F., Mylonas, I."Immunolabelling of the inhibin/activin-βC subunit in normal and malignant human uterine cervical tissue and cervical cancer cell lines ". Oncology Reports 25.1 (2011): 147-152.
Chicago
Blankenstein, T., Jückstock, J., Shabani, N., Kunze, S., Brüning, A., Bergauer, F., Mylonas, I."Immunolabelling of the inhibin/activin-βC subunit in normal and malignant human uterine cervical tissue and cervical cancer cell lines ". Oncology Reports 25, no. 1 (2011): 147-152. https://doi.org/10.3892/or_00001054
Copy and paste a formatted citation
x
Spandidos Publications style
Blankenstein T, Jückstock J, Shabani N, Kunze S, Brüning A, Bergauer F and Mylonas I: Immunolabelling of the inhibin/activin-βC subunit in normal and malignant human uterine cervical tissue and cervical cancer cell lines . Oncol Rep 25: 147-152, 2011.
APA
Blankenstein, T., Jückstock, J., Shabani, N., Kunze, S., Brüning, A., Bergauer, F., & Mylonas, I. (2011). Immunolabelling of the inhibin/activin-βC subunit in normal and malignant human uterine cervical tissue and cervical cancer cell lines . Oncology Reports, 25, 147-152. https://doi.org/10.3892/or_00001054
MLA
Blankenstein, T., Jückstock, J., Shabani, N., Kunze, S., Brüning, A., Bergauer, F., Mylonas, I."Immunolabelling of the inhibin/activin-βC subunit in normal and malignant human uterine cervical tissue and cervical cancer cell lines ". Oncology Reports 25.1 (2011): 147-152.
Chicago
Blankenstein, T., Jückstock, J., Shabani, N., Kunze, S., Brüning, A., Bergauer, F., Mylonas, I."Immunolabelling of the inhibin/activin-βC subunit in normal and malignant human uterine cervical tissue and cervical cancer cell lines ". Oncology Reports 25, no. 1 (2011): 147-152. https://doi.org/10.3892/or_00001054
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