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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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January 2011 Volume 25 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Overexpression of sorcin results in multidrug resistance in gastric cancer cells with up-regulation of P-gp

  • Authors:
    • Qingchun He
    • Guiying Zhang
    • Defu Hou
    • Aiming Leng
    • Meihua Xu
    • Jie Peng
    • Ting Liu

  • View Affiliations / Copyright

    Affiliations: Department of Emergency, Central South University, Changsha 410008, Hunan province, P.R. China
  • Pages: 237-243
    |
    Published online on: January 1, 2011
       https://doi.org/10.3892/or_00001066
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Abstract

Sorcin, a calcium-binding protein was found up-regulated in the vincristine-induced multi-drug resistance (MDR) gastric cancer cell line SGC7901/VCR, over its parental SGC7901 cells in our previous proteomic studies. The present study explored the role and mechanism of sorcin in the development of MDR in gastric cancer. We constructed the recombinant plasmids FLAG-sorsin-pcDNA3.1 containing the full open reading frame of sorcin and a FLAG affinity tag. Overexpression of sorcin by gene transfection was able to confer drug resistance to vincristine, adriamycin, taxol and 5-fluorouracil in SGC7901 cells. Down-regulation of sorcin expression by sorcin antisense oligonucleutides, (ASO) increased sensitivity to vincristine. The intracellular concentration of vincristine in SGC7901 cells decreased in sorcin transfected cells and increased in sorcin ASO-transfected cells, indicating that sorcin had a direct or indirect function on pumping the drug out of cells. Overexpression of sorcin up-regulated the expression of P-gp and P-gp inhibitor verapamil partially reversed the sorcin-mediated MDR in SGC7901 cell, suggesting that regulation of P-gp might be one of the mechanisms of sorcin-mediated MDR. The further study of the interaction protein of sorcin may be helpful for understanding the mechanisms of MDR in gastric cancer and developing possible strategies to treat gastric cancer.

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Copy and paste a formatted citation
Spandidos Publications style
He Q, Zhang G, Hou D, Leng A, Xu M, Peng J and Liu T: Overexpression of sorcin results in multidrug resistance in gastric cancer cells with up-regulation of P-gp . Oncol Rep 25: 237-243, 2011.
APA
He, Q., Zhang, G., Hou, D., Leng, A., Xu, M., Peng, J., & Liu, T. (2011). Overexpression of sorcin results in multidrug resistance in gastric cancer cells with up-regulation of P-gp . Oncology Reports, 25, 237-243. https://doi.org/10.3892/or_00001066
MLA
He, Q., Zhang, G., Hou, D., Leng, A., Xu, M., Peng, J., Liu, T."Overexpression of sorcin results in multidrug resistance in gastric cancer cells with up-regulation of P-gp ". Oncology Reports 25.1 (2011): 237-243.
Chicago
He, Q., Zhang, G., Hou, D., Leng, A., Xu, M., Peng, J., Liu, T."Overexpression of sorcin results in multidrug resistance in gastric cancer cells with up-regulation of P-gp ". Oncology Reports 25, no. 1 (2011): 237-243. https://doi.org/10.3892/or_00001066
Copy and paste a formatted citation
x
Spandidos Publications style
He Q, Zhang G, Hou D, Leng A, Xu M, Peng J and Liu T: Overexpression of sorcin results in multidrug resistance in gastric cancer cells with up-regulation of P-gp . Oncol Rep 25: 237-243, 2011.
APA
He, Q., Zhang, G., Hou, D., Leng, A., Xu, M., Peng, J., & Liu, T. (2011). Overexpression of sorcin results in multidrug resistance in gastric cancer cells with up-regulation of P-gp . Oncology Reports, 25, 237-243. https://doi.org/10.3892/or_00001066
MLA
He, Q., Zhang, G., Hou, D., Leng, A., Xu, M., Peng, J., Liu, T."Overexpression of sorcin results in multidrug resistance in gastric cancer cells with up-regulation of P-gp ". Oncology Reports 25.1 (2011): 237-243.
Chicago
He, Q., Zhang, G., Hou, D., Leng, A., Xu, M., Peng, J., Liu, T."Overexpression of sorcin results in multidrug resistance in gastric cancer cells with up-regulation of P-gp ". Oncology Reports 25, no. 1 (2011): 237-243. https://doi.org/10.3892/or_00001066
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