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Review Open Access

Protective effects of Wenxin Keli against cardiac arrhythmias (Review)

  • Authors:
    • Shristi Dahal
    • Mengqi Gong
    • Shaohua Guo
    • Gary Tse
    • Tong Liu
  • View Affiliations / Copyright

    Affiliations: Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin 300211, P.R. China
    Copyright: © Dahal et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 2
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    Published online on: April 6, 2020
       https://doi.org/10.3892/wasj.2020.43
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Abstract

Cardiac arrhythmias represent a significant problem globally. Combined traditional Chinese and Western medicine is being integrated into current therapeutic trials in continued efforts to suppress arrhythmias that are predicted to escalate in the face of increasing life expectancy and medical advances. This review highlights regulatory mechanisms and major target sites of a patented, traditional Chinese drug, Wenxin Keli (WXKL). It describes the roles of individual components of WXKL via multiple pathways in interrupting reentry, reducing automaticity and preventing arrhythmogenic substrates. It further elucidates the effects of WXKL on atrial and ventricular electrophysiology, highlighting its weaker effects on rapid sodium curent (INa), as well as its multi‑channel block, apart from atrial selectivity. In addition, the present review article incorporates diverse actions of WXKL in the reduction of reactive oxygen species levels, CX43 regulation, calcium handling, Ca2+/calmodulin‑dependent protein kinase II (CaMKII) modulation and neurohumoral system regulation. Apart from its role in managing angina and heart failure shown in experimental and clinical models, the aforementioned effects enable WXKL to maintain sinus rhythm and prevent cardiac arrhythmias and sudden cardiac death associated with multiple comorbidities. Based on the results from various studies, it has minimal side‑effects and is less proarrhythmic with an efficacy that matches that of western drugs. Varying effects of WXKL on multiple ion channels, intercellular conduction, and second messenger and redox systems have opened novel doors in managing arrhythmias.
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1 

Tse G, Yan BP, Chan YW, Tian XY and Huang Y: Reactive oxygen species, endoplasmic reticulum stress and mitochondrial dysfunction: The link with cardiac arrhythmogenesis. Front Physiol. 7(313)2016.PubMed/NCBI View Article : Google Scholar

2 

Lippi G, Sanchis.Gomar F and Cervellin G: Global epidemiology of atrial fibrillation: An increasing epidemic and public health challenge. Int J Stroke: Jan 19, 2020 (Epub ahead of print).

3 

Murakoshi N and Aonuma K: Epidemiology of arrhythmias and sudden cardiac death in Asia. Circ J. 77:2419–2431. 2013.PubMed/NCBI View Article : Google Scholar

4 

Guo Y, Tian Y, Wang H, Si Q, Wang Y and Lip GYH: Prevalence, incidence, and lifetime risk of atrial fibrillation in China: New insights into the global burden of atrial fibrillation. Chest. 147:109–119. 2015.PubMed/NCBI View Article : Google Scholar

5 

John RM, Tedrow UB, Koplan BA, Albert CM, Epstein LM, Sweeney MO, Miller AL, Michaud GF and Stevenson WG: Ventricular arrhythmias and sudden cardiac death. Lancet. 380:1520–1529. 2012.PubMed/NCBI View Article : Google Scholar

6 

Wang T, Lu M, Du Q, Yao X, Zhang P, Chen X, Xie W, Li Z, Ma Y and Zhu Y: An integrated anti-arrhythmic target network of compound Chinese medicine Wenxin Keli revealed by combined machine learning and molecular pathway analysis [corrected]. Mol Biosyst. 13:1018–1030. 2017.PubMed/NCBI View Article : Google Scholar

7 

Kalifa J and Avula UM: The Chinese herb extract Wenxin Keli: Atrial selectivity from the Far East. Hear Rhythm. 9:132–133. 2012.PubMed/NCBI View Article : Google Scholar

8 

Wang X, Wang X, Gu Y, Wang T and Huang C: Wenxin Keli attenuates ischemia-induced ventricular arrhythmias in rats: Involvement of L-type calcium and transient outward potassium currents. Mol Med Rep. 7:519–524. 2012.

9 

Tang Q: Effects of Nardostachys chinensis Batal extract on sodium and calcium channels in rabbit ventricular myocytes. Chin J Cardiol. 32:267–70. 2004.(In Chinese).

10 

Brenyo A and Aktas MK: Review of complementary and alternative medical treatment of arrhythmias. Am J Cardiol. 113:897–903. 2014.PubMed/NCBI View Article : Google Scholar

11 

He M, Lv Z, Yang ZW, Huang JL and Liu F: Efficacy and safety of Chinese herbal medicine Wenxin Keli for ventricular premature be ats: A systematic review. Complement Ther Med. 29:181–189. 2016.PubMed/NCBI View Article : Google Scholar

12 

Hou J, Li W, Guo K, Chen XM, Chen YH, Li CY, Zhao BC, Zhao J, Wang H, Wang YP and Li YG: Antiarrhythmic effects and potential mechanism of WenXin KeLi in cardiac Purkinje cells. Hear Rhythm. 13:973–982. 2016.PubMed/NCBI View Article : Google Scholar

13 

Dong Y, Liao J, Yao K, Jiang W and Wang J: Application of traditional Chinese medicine in treatment of atrial fibrillation. Evid Based Complement Alternat Med. 2017(1381732)2017.PubMed/NCBI View Article : Google Scholar

14 

Yang X, Chen Y, Li Y, Ren X, Xing Y and Shang H: Effects of Wenxin Keli on Cardiac hypertrophy and arrhythmia via regulation of the Calcium/Calmodulin dependent Kinase II signaling pathway. Biomed Res Int. 2017(1569235)2017.PubMed/NCBI View Article : Google Scholar

15 

Wang X, Wang Y, Feng X, Lu Y, Zhang Y, Wang W and Zhu W: Systematic review and meta-analysis of randomized controlled trials on Wenxin Keli. Drug Des Devel Ther. 10:3725–3736. 2016.PubMed/NCBI View Article : Google Scholar

16 

Li J, Hu D, Song X, Han T, Gao Y and Xing Y: The role of biologically active ingredients from natural drug treatments for arrhythmias in different mechanisms. Biomed Res Int. 2017(4615727)2017.PubMed/NCBI View Article : Google Scholar

17 

Jiang M, Wang Q, Chen J, Wang Y, Fan G and Zhu Y: Comparative metabonomics of Wenxin Keli and verapamil reveals differential roles of gluconeogenesis and fatty acid β-oxidation in myocardial injury protection. Sci Rep. 7(8739)2017.PubMed/NCBI View Article : Google Scholar

18 

Burashnikov A, Petroski A, Hu D, Barajas-Martinez H and Antzelevitch C: Atrial-selective inhibition of sodium-channel current by Wenxin Keli is effective in suppressing atrial fibrillation. Hear Rhythm. 9:125–131. 2012.PubMed/NCBI View Article : Google Scholar

19 

Chen Y, Li Y, Guo L, Chen W, Zhao M, Gao Y, Wu A, Lou L, Wang J, Liu X and Xing Y: Effects of Wenxin Keli on the action potential and L-type calcium current in rats with transverse aortic constriction-induced heart failure. Evid Based Complement Alternat Med. 2013(572078)2013.PubMed/NCBI View Article : Google Scholar

20 

Li M, Qiu R, Tian G, Zhang X, Li C, Chen S, Zhang Q and Shang H: Wenxin Keli for Ventricular premature complexes with Heart failure: A systematic review and meta-analysis of randomized clinical trials. Complement Ther Med. 33:85–93. 2017.PubMed/NCBI View Article : Google Scholar

21 

Tse G and Yeo JM: Conduction abnormalities and ventricular arrhythmogenesis: The roles of sodium channels and gap junctions. Int J Cardiol Heart Vasc. 9:75–82. 2015.PubMed/NCBI View Article : Google Scholar

22 

Wu A, Zhao M, Lou L, Zhai J, Zhang D, Zhu H, Gao Y, Shang H and Chai L: Effect of Wenxin Granules on Gap Junction and miR-1 in rats with myocardial infarction. Biomed Res Int. 2017(3495021)2017.PubMed/NCBI View Article : Google Scholar

23 

Du M, Huang K, Gao L, Yang L, Wang WS, Wang B, Huang K and Huang D: Nardosinone protects H9c2 cardiac cells from angiotensin II-induced hypertrophy. J Huazhong Univ Sci Technolog Med Sci. 33:822–826. 2013.PubMed/NCBI View Article : Google Scholar

24 

Minoura Y, Panama BK, Nesterenko VV, Betzenhauser M, Barajas-Martínez H, Hu D, Di Diego JM and Antzelevitch C: Effect of Wenxin Keli and quinidine to suppress arrhythmogenesis in an experimental model of Brugada syndrome. Hear Rhythm. 10:1054–1062. 2013.PubMed/NCBI View Article : Google Scholar

25 

Sun J, Sun G, Meng X, Wang H, Wang M, Qin M, Ma B, Luo Y, Yu Y, Chen R, et al: Ginsenoside RK3 prevents Hypoxia-Reoxygenation induced apoptosis in H9c2 Cardiomyocytes via AKT and MAPK pathway. Evid Based Complement Alternat Med. 2013(690190)2013.PubMed/NCBI View Article : Google Scholar

26 

Li L, Pan CS, Yan L, Cui YC, Liu YY, Mu HN, He K, Hu BH, Chang X, Sun K, et al: Ginsenoside Rg1 ameliorates rat myocardial ischemia-reperfusion injury by modulating energy metabolism pathways. Front Physiol. 9(78)2018.PubMed/NCBI View Article : Google Scholar

27 

Zhu D, Wu L, Li CR, Wang XW, Ma YJ, Zhong ZY, Zhao HB, Cui J, Xun SF, Huang XL, et al: Ginsenoside Rg1 protects rat cardiomyocyte from hypoxia/reoxygenation oxidative injury via antioxidant and intracellular calcium homeostasis. J Cell Biochem. 108:117–124. 2009.PubMed/NCBI View Article : Google Scholar

28 

Song H, Wang P, Liu J and Wang C: Panax notoginseng preparations for unstable angina pectoris: A systematic review and meta-analysis. Phyther Res. 31:1162–1172. 2017.PubMed/NCBI View Article : Google Scholar

29 

Yu G and Wang J: Exploring mechanisms of Panax notoginseng saponins in treating coronary heart disease by integrating gene interaction network and functional enrichment analysis. Chin J Integr Med. 22:589–596. 2016.PubMed/NCBI View Article : Google Scholar

30 

Zhou Z, Wang J, Song Y, He Y, Zhang C, Liu C, Zhao H, Dun Y, Yuan D and Wang T: Panax notoginseng saponins attenuate cardiomyocyte apoptosis through mitochondrial pathway in natural aging rats. Phyther Res. 32:243–250. 2018.PubMed/NCBI View Article : Google Scholar

31 

Cui X, Wang S, Cao H, Guo H, Li Y, Xu F, Zheng M, Xi X and Han C: A review: The bioactivities and pharmacological applications of polygonatum sibiricum polysaccharides. Molecules. 23(pii: E1170)2018.PubMed/NCBI View Article : Google Scholar

32 

Zhu X, Wu W, Chen X, Yang F, Zhang J and Hou J: Protective effects of Polygonatum sibiricum polysaccharide on acute heart failure in rats 1. Acta Cir Bras. 33:868–878. 2018.PubMed/NCBI View Article : Google Scholar

33 

Chang KS, Lee NH, Kuo WW, Hu WS, Chang MH, Tsai FJ, Tsai KH, Yang YS, Chen TS and Huang CY: Dung-Shen downregulates the synergistic apoptotic effects of angiotensin II plus Leu 27-IGF II on cardiomyoblasts. Acta Cardiol Sin. 30:56–66. 2014.PubMed/NCBI

34 

Tsai KH, Lee NH, Chen GY, Hu WS, Tsai CY, Chang MH, Jong GP, Kuo CH, Tzang BS, Tsai FJ, et al: Dung-Shen (Codonopsis pilosula) attenuated the cardiac-impaired insulin-like growth factor II receptor pathway on myocardial cells. Food Chem. 138:1856–1867. 2013.PubMed/NCBI View Article : Google Scholar

35 

Aguilar M and Nattel S: The past, present, and potential future of sodium channel block as an atrial fibrillation suppressing strategy. J Cardiovasc Pharmacol. 66:432–440. 2015.PubMed/NCBI View Article : Google Scholar

36 

Burashnikov A, Di Diego JM, Zygmunt AC, Belardinelli L and Antzelevitch C: Atrium-selective sodium channel block as a strategy for suppression of atrial fibrillation: Differences in sodium channel inactivation between atria and ventricles and the role of ranolazine. Circulation. 116:1449–1457. 2007.PubMed/NCBI View Article : Google Scholar

37 

Burashnikov A and Antzelevitch C: Role of late sodium channel current block in the management of atrial fibrillation. Cardiovasc Drugs Ther. 27:79–89. 2013.PubMed/NCBI View Article : Google Scholar

38 

Gharaviri A, Verheule S, Eckstein J, Potse M, Krause R, Auricchio A, Kuijpers NHL and Schotten U: Effect of Na+-channel blockade on the three-dimensional substrate of atrial fibrillation in a model of Endo-Epicardial dissociation and transmural conduction. Europace. 20 (Suppl 3):iii69–iii76. 2018.PubMed/NCBI View Article : Google Scholar

39 

Hu D, Barajas-Martínez H, Burashnikov A, Panama BK, Cordeiro JM and Antzelevitch C: Mechanisms underlying atrial-selective block of sodium channels by Wenxin Keli: Experimental and theoretical analysis. Int J Cardiol. 207:326–334. 2016.PubMed/NCBI View Article : Google Scholar

40 

Xiao J, Zhao Q, Kebbati AH, Deng H, Wang X, Dai Z, Yu S and Huang C: Wenxin Keli suppresses atrial substrate remodeling after epicardial ganglionic Plexi ablation. Exp Clin Cardiol. 18:153–157. 2013.PubMed/NCBI

41 

Zhang N, Tse G, Dahal S, Yang Y, Gong M, Chan CZY, Liu E, Xu G, Letsas KP, Korantzopoulos P, et al: Efficacy of Wenxin Keli Plus Amiodarone versus Amiodarone Monotherapy in treating recent-onset atrial fibrillation. Cardiol Res Pract. 2018(6047271)2018.PubMed/NCBI View Article : Google Scholar

42 

Meng Z, Tan J, He Q, Zhu M, Li X, Zhang J, Jia Q, Wang S, Zhang G and Zheng W: Wenxin Keli versus Sotalol for paroxysmal atrial fibrillation caused by hyperthyroidism: A prospective, open label, and randomized study. Evid Based Complement Alternat Med. 2015(101904)2015.PubMed/NCBI View Article : Google Scholar

43 

Guo D, Lian J, Liu T, Cox R, Margulies KB, Kowey PR and Yan GX: Contribution of late sodium current (INa-L) to rate adaptation of ventricular repolarization and reverse use-dependence of QT-prolonging agents. Hear Rhythm. 8:762–769. 2011.PubMed/NCBI View Article : Google Scholar

44 

Antzelevitch C: Electrical heterogeneity, cardiac arrhythmias, and the sodium channel. Circ Res. 87:964–965. 2000.PubMed/NCBI View Article : Google Scholar

45 

Sicouri S, Timothy KW, Zygmunt AC, Glass A, Goodrow RJ, Belardinelli L and Antzelevitch C: Cellular basis for the electrocardiographic and arrhythmic manifestations of Timothy syndrome: Effects of ranolazine. Hear Rhythm. 4:638–647. 2007.PubMed/NCBI View Article : Google Scholar

46 

Qi D, Yang Z, Robinson VM, Li J, Gao C, Guo D, Kowey PR and Yan GX: Heterogeneous distribution of INa-L determines interregional differences in rate adaptation of repolarization. Hear Rhythm. 12:1295–1303. 2015.PubMed/NCBI View Article : Google Scholar

47 

Burashnikov A: Late INa Inhibition as an Antiarrhythmic Strategy. J Cardiovasc Pharmacol. 70:159–167. 2017.PubMed/NCBI View Article : Google Scholar

48 

Xue X, Guo D, Sun H, Wang D, Li J, Liu T, Yang L, Shu J and Yan GX: Wenxin Keli suppresses ventricular triggered arrhythmias via selective inhibition of late sodium current. Pacing Clin Electrophysiol. 36:732–740. 2013.PubMed/NCBI View Article : Google Scholar

49 

Xiao L, Koopmann TT, Ördög B, Postema PG, Verkerk AO, Iyer V, Sampson KJ, Boink GJ, Mamarbachi MA, Varro A, et al: Unique cardiac Purkinje fiber transient outward current β-subunit composition: A potential molecular link to idiopathic ventricular fibrillation. Circ Res. 112:1310–1322. 2013.PubMed/NCBI View Article : Google Scholar

50 

Li J, Xie D, Huang J, Lv F, Shi D, Liu Y, Lin L, Geng L, Wu Y, Liang D and Chen YH: Cold-inducible RNA-binding protein regulates cardiac repolarization by targeting transient outward potassium channels. Circ Res. 116:1655–1659. 2015.PubMed/NCBI View Article : Google Scholar

51 

Bohnen MS, Iyer V, Sampson KJ and Kass RS: Novel mechanism of transient outward potassium channel current regulation in the heart: Implications for cardiac electrophysiology in health and disease. Circ Res. 116:1633–1635. 2015.PubMed/NCBI View Article : Google Scholar

52 

Cho JH, Zhang R, Kilfoil PJ, Gallet R, de Couto G, Bresee C, Goldhaber JI, Marbán E and Cingolani E: Delayed repolarization underlies ventricular arrhythmias in rats with heart failure and preserved ejection fraction. Circulation. 136:2037–2050. 2017.PubMed/NCBI View Article : Google Scholar

53 

Zheng M, Liu Z, Liu N, Hou C, Pu J and Zhang S: The effect of Wenxin Keli on the mRNA expression profile of rabbits with myocardial infarction. Evid Based Complement Alternat Med. 2016(2352614)2016.PubMed/NCBI View Article : Google Scholar

54 

Zheng R, Tian G, Zhang Q, Wu L, Xing Y and Shang H: Clinical safety and efficacy of Wenxin keli-amiodarone combination on heart failure complicated by ventricular arrhythmia: A systematic review and meta-analysis. Front Physiol. 9(487)2018.PubMed/NCBI View Article : Google Scholar

55 

Yang G, Sau C, Lai W, Cichon J and Li W: Sleep promotes branch-specific formation of dendritic spines after learning. Science. 344:1173–1178. 2014.PubMed/NCBI View Article : Google Scholar

56 

Antzelevitch C and Patocskai B: Brugada Syndrome: Clinical, Genetic, Molecular, Cellular, and Ionic Aspects. Curr Probl Cardiol. 41:7–57. 2016.PubMed/NCBI View Article : Google Scholar

57 

van Opbergen CJM, den Braven L, Delmar M and van Veen TAB: Mitochondrial Dysfunction as Substrate for Arrhythmogenic Cardiomyopathy: A search for new disease mechanisms. Front Physiol. 10(1496)2019.PubMed/NCBI View Article : Google Scholar

58 

Ilkan Z and Akar FG: The mitochondrial translocator protein and the emerging link between oxidative stress and arrhythmias in the diabetic heart. Front Physiol. 9(1518)2018.PubMed/NCBI View Article : Google Scholar

59 

Ren X, Wang X, Yuan M, Tian C, Li H, Yang X, Li X, Li Y, Yang Y, Liu N, et al: Mechanisms and treatments of oxidative stress in atrial fibrillation. Curr Pharm Des. 24:3062–3071. 2018.PubMed/NCBI View Article : Google Scholar

60 

Faria A and Persaud SJ: Cardiac oxidative stress in diabetes: Mechanisms and therapeutic potential. Pharmacol Ther. 172:50–62. 2017.PubMed/NCBI View Article : Google Scholar

61 

Köhler AC, Sag CM and Maier LS: Reactive oxygen species and excitation-contraction coupling in the context of cardiac pathology. J Mol Cell Cardiol. 73:92–102. 2014.PubMed/NCBI View Article : Google Scholar

62 

Gong M, Yuan M, Meng L, Zhang Z, Tse G, Zhao Y, Zhang Y, Yuan M, Liang X, Fan G, et al: Wenxin Keli regulates mitochondrial oxidative stress and homeostasis and improves atrial remodeling in diabetic rats. Oxid Med Cell Longev. 2020(2468031)2020.PubMed/NCBI View Article : Google Scholar

63 

Tian G, Sun Y, Liu S, Li C, Chen S, Qiu R, Zhang X, Li Y, Li M and Shang H: Therapeutic effects of Wenxin Keli in cardiovascular diseases: An experimental and mechanism overview. Front Pharmacol. 9(1005)2018.PubMed/NCBI View Article : Google Scholar

64 

Nagibin V, Egan Benova T, Viczenczova C, Szeiffova Bacova B, Dovinova I, Barancik M and Tribulova N: Ageing related down-regulation of myocardial connexin-43 and up-regulation of MMP-2 may predict propensity to atrial fibrillation in experimental animals. Physiol Res. 65 (Suppl 1):S91–S100. 2016.PubMed/NCBI View Article : Google Scholar

65 

Kato T, Iwasaki Y and Nattel S: Connexins and atrial fibrillation. Circulation. 125:203–206. 2011.

66 

Shu C, Huang W, Zeng Z, He Y, Luo B, Liu H, Li J and Xu J: Connexin 43 is involved in the sympathetic atrial fibrillation in canine and canine atrial myocytes. Anatol J Cardiol. 18:3–9. 2017.PubMed/NCBI View Article : Google Scholar

67 

Paul M, Wichter T, Gerss J, Arps V, Schulze-Bahr E, Robenek H, Breithardt G and Weissen-Plenz G: Connexin expression patterns in arrhythmogenic right ventricular cardiomyopathy. Am J Cardiol. 111:1488–1495. 2013.PubMed/NCBI View Article : Google Scholar

68 

Milberg P, Fink M, Pott C, Frommeyer G, Biertz J, Osada N, Stypmann J, Mönnig G, Koopmann M, Breithardt G and Eckardt L: Blockade of I(Ca) suppresses early afterdepolarizations and reduces transmural dispersion of repolarization in a whole heart model of chronic heart failure. Br J Pharmacol. 166:557–568. 2012.PubMed/NCBI View Article : Google Scholar

69 

Xing Y, Gao Y, Chen J, Zhu H, Wu A, Yang Q, Teng F, Zhang DM, Xing Y, Gao K, et al: Wenxin-Keli regulates the calcium/calmodulin-dependent protein kinase II signal transduction pathway and inhibits cardiac arrhythmia in rats with myocardial infarction. Evid Based Complement Alternat Med. 2013(464508)2013.PubMed/NCBI View Article : Google Scholar

70 

Luo A, Liu Z, Cao Z, Hao J, Wu L, Fu C, Zeng M, Jiang W, Zhang P, Zhao B, et al: Wenxin Keli diminishes Ca2+ overload induced by hypoxia/reoxygenation in cardiomyocytes through inhibiting INaL and ICaL. Pacing Clin Electrophysiol. 40:1412–1425. 2017.PubMed/NCBI View Article : Google Scholar

71 

Maier LS and Bers DM: Role of Ca2+/calmodulin-dependent protein kinase (CaMK) in excitation-contraction coupling in the heart. Cardiovasc Res. 73:631–640. 2007.PubMed/NCBI View Article : Google Scholar

72 

Heijman J, Voigt N, Wehrens XH and Dobrev D: Calcium dysregulation in atrial fibrillation: The role of CaMKII. Front Pharmacol. 5(30)2014.PubMed/NCBI View Article : Google Scholar

73 

Lai Y, Yu L and Jiang H: Autonomic neuromodulation for preventing and treating ventricular arrhythmias. Front Physiol. 10(200)2019.PubMed/NCBI View Article : Google Scholar

74 

Inoue H and Zipes DP: Results of sympathetic denervation in the canine heart: Supersensitivity that may be arrhythmogenic. Circulation. 75:877–887. 1987.PubMed/NCBI View Article : Google Scholar

75 

Yanowitz F, Preston JB and Abildskov JA: Functional distribution of right and left stellate innervation to the ventricles. Production of neurogenic electrocardiographic changes by unilateral alteration of sympathetic tone. Circ Res. 18:416–428. 1966.PubMed/NCBI View Article : Google Scholar

76 

Chen PS, Chen LS, Cao JM, Sharifi B, Karagueuzian HS and Fishbein MC: Sympathetic nerve sprouting, electrical remodeling and the mechanisms of sudden cardiac death. Cardiovasc Res. 50:409–416. 2001.PubMed/NCBI View Article : Google Scholar

77 

Ng GA: Vagal modulation of cardiac ventricular arrhythmia. Exp Physiol. 99:295–299. 2014.PubMed/NCBI View Article : Google Scholar

78 

Naggar I, Uchida S, Kamran H, Lazar J and Stewart M: Autonomic boundary conditions for ventricular fibrillation and their implications for a novel defibrillation technique. J Physiol Sci. 62:479–492. 2012.PubMed/NCBI View Article : Google Scholar

79 

Meng L, Shivkumar K and Ajijola O: Autonomic regulation and ventricular arrhythmias. Curr Treat Options Cardiovasc Med. 20(38)2018.PubMed/NCBI View Article : Google Scholar

80 

Takigawa M, Noda T, Shimizu W, Miyamoto K, Okamura H, Satomi K, Suyama K, Aihara N, Kamakura S and Kurita T: Seasonal and circadian distributions of ventricular fibrillation in patients with Brugada syndrome. Hear Rhythm. 5:1523–1527. 2008.PubMed/NCBI View Article : Google Scholar

81 

Shen MJ and Zipes DP: Role of the autonomic nervous system in modulating cardiac arrhythmias. Circ Res. 114:1004–1021. 2014.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Dahal S, Gong M, Guo S, Tse G and Liu T: Protective effects of Wenxin Keli against cardiac arrhythmias (Review). World Acad Sci J 2: 2, 2020.
APA
Dahal, S., Gong, M., Guo, S., Tse, G., & Liu, T. (2020). Protective effects of Wenxin Keli against cardiac arrhythmias (Review). World Academy of Sciences Journal, 2, 2. https://doi.org/10.3892/wasj.2020.43
MLA
Dahal, S., Gong, M., Guo, S., Tse, G., Liu, T."Protective effects of Wenxin Keli against cardiac arrhythmias (Review)". World Academy of Sciences Journal 2.3 (2020): 2.
Chicago
Dahal, S., Gong, M., Guo, S., Tse, G., Liu, T."Protective effects of Wenxin Keli against cardiac arrhythmias (Review)". World Academy of Sciences Journal 2, no. 3 (2020): 2. https://doi.org/10.3892/wasj.2020.43
Copy and paste a formatted citation
x
Spandidos Publications style
Dahal S, Gong M, Guo S, Tse G and Liu T: Protective effects of Wenxin Keli against cardiac arrhythmias (Review). World Acad Sci J 2: 2, 2020.
APA
Dahal, S., Gong, M., Guo, S., Tse, G., & Liu, T. (2020). Protective effects of Wenxin Keli against cardiac arrhythmias (Review). World Academy of Sciences Journal, 2, 2. https://doi.org/10.3892/wasj.2020.43
MLA
Dahal, S., Gong, M., Guo, S., Tse, G., Liu, T."Protective effects of Wenxin Keli against cardiac arrhythmias (Review)". World Academy of Sciences Journal 2.3 (2020): 2.
Chicago
Dahal, S., Gong, M., Guo, S., Tse, G., Liu, T."Protective effects of Wenxin Keli against cardiac arrhythmias (Review)". World Academy of Sciences Journal 2, no. 3 (2020): 2. https://doi.org/10.3892/wasj.2020.43
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