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Molecular insight into apoptosis mediated by flavones in cancer (Review)

  • Authors:
    • Ritu Raina
    • Arif Hussain
    • Ria Sharma
  • View Affiliations

  • Published online on: April 27, 2020     https://doi.org/10.3892/wasj.2020.47
  • ArticleNumber: 6
  • Copyright: © Raina et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Apoptosis, a vital component of normal cell growth and development is characterized by diverse morphological characteristics. The evasion of apoptosis is an important hallmark of cancer; thus, the ability to induce apoptosis and suppress cell growth is a promising therapeutic approach and a highly active area of cancer research. Although chemotherapeutics can be used to achieve this, their use is associated with high levels of toxicity. Hence, focus is being shifted towards plant-based compounds due to their low toxicity, easy availability and affordability. Flavonoids, a subclass of polyphenols, have attracted attention as potential anticancer candidates due to their ability to induce apoptosis and thus, to reduce cellular proliferation specifically in cancer cells. Several pro- and anti-apoptotic proteins have been identified, although their exact modes of action have yet to be elucidated. Therefore, research continues to focus on the pathways followed by key proteins involved in cell cycle progression and apoptosis. This arena of apoptosis research has been moving forward at a remarkably rapid pace. The aim of the present review was to provide an overall summary of the presently available data on the modulation of the process of apoptosis by flavones in different types of cancer.
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May 2020
Volume 2 Issue 3

Print ISSN: 2632-2900
Online ISSN:2632-2919

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APA
Raina, R., Hussain, A., & Sharma, R. (2020). Molecular insight into apoptosis mediated by flavones in cancer (Review). World Academy of Sciences Journal, 2, 6. https://doi.org/10.3892/wasj.2020.47
MLA
Raina, R., Hussain, A., Sharma, R."Molecular insight into apoptosis mediated by flavones in cancer (Review)". World Academy of Sciences Journal 2.3 (2020): 6.
Chicago
Raina, R., Hussain, A., Sharma, R."Molecular insight into apoptosis mediated by flavones in cancer (Review)". World Academy of Sciences Journal 2, no. 3 (2020): 6. https://doi.org/10.3892/wasj.2020.47